Impaired Th2 Subset Development in the Absence of CD4

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

RAG-1-deficient mice have no mature B and T lymphocytes

1992 • 2,859 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

Acquisition of Lymphokine-Producing Phenotype by CD4+ T Cells

1994 • 1,573 citations

An αβ T Cell Receptor Structure at 2.5 Å and Its Orientation in the TCR-MHC Complex

1996 • 1,282 citations

The Regulation of Immunity to Leishmania Major

1995 • 1,265 citations

IL-12-Deficient Mice Are Defective in IFNγ Production and Type 1 Cytokine Responses

1996 • 991 citations

Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo

1994 • 967 citations

CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3.

1994 • 862 citations

Interaction between CD4 and class II MHC molecules mediates cell adhesion

1987 • 823 citations

The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model.

1995 • 768 citations

Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cells.

1995 • 699 citations

Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4

1991 • 695 citations

Role of NK1.1 ⁺ T Cells in a T _H 2 Response and in Immunoglobulin E Production

1995 • 508 citations

Genetically resistant mice lacking interleukin‐12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response

1996 • 483 citations

A Subset of CD4 ⁺ Thymocytes Selected by MHC Class I Molecules

1994 • 464 citations

A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development

1994 • 418 citations

Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo.

1995 • 410 citations

Lymphoid Development in Mice Congenitally Lacking T Cell Receptor αβ-Expressing Cells

1992 • 371 citations

MHC class II interaction with CD4 mediated by a region analogous to the MHC class I binding site for CD8

1992 • 368 citations

Leishmania promastigotes evade interleukin 12 (IL-12) induction by macrophages and stimulate a broad range of cytokines from CD4+ T cells during initiation of infection.

1994 • 365 citations

The Ick tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain

1989 • 362 citations

Murine Th1 and Th2 clones proliferate optimally in response to distinct antigen-presenting cell populations.

1991 • 355 citations

The Importance of Th2 Cytokines in Protective Immunity to Nematodes

1992 • 352 citations

Expression Cloning of a Protective Leishmania Antigen

1995 • 351 citations

Distinct roles for the costimulatory ligands B7-1 and B7-2 in T helper cell differentiation?

1995 • 347 citations

CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes

1996 • 326 citations

Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice

1993 • 275 citations

Identification of a CD4 binding site on the β2 domain of HLA-DR molecules

1992 • 272 citations

Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling.

1994 • 248 citations

CD8 modulation of T-cell antigen receptor–ligand interactions on living cytotoxic T lymphocytes

1995 • 245 citations

Specificity and flexibility in thymic selection

1994 • 221 citations

Syk Is Activated by Phosphotyrosine-containing Peptides Representing the Tyrosine-based Activation Motifs of the High Affinity Receptor for IgE

1995 • 207 citations

Beta 2-microglobulin-dependent NK1.1+ T cells are not essential for T helper cell 2 immune responses.

1996 • 207 citations

T _H 1 and T _H 2 Cell Antigen Receptors in Experimental Leishmaniasis

1993 • 204 citations

Genetic mapping of a murine locus controlling development of T helper 1/T helper 2 type responses.

1996 • 204 citations

Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4.

1993 • 201 citations

Selective development of T helper (Th)2 cells induced by continuous administration of low dose soluble proteins to normal and beta(2)-microglobulin-deficient BALB/c mice.

1996 • 198 citations

Major histocompatibility complex binding affinity of an antigenic determinant is crucial for the differential secretion of interleukin 4/5 or interferon gamma by T cells.

1995 • 178 citations

IL-4 treatment can cure established gastrointestinal nematode infections in immunocompetent and immunodeficient mice.

1995 • 166 citations

The αβ T Cell Receptor Can Replace the γδ Receptor in the Development of γδ Lineage Cells

1996 • 161 citations

Mutational analysis of the interaction between CD4 and class II MHC: Class II antigens contact CD4 on a surface opposite the gp120-binding site

1991 • 146 citations

Development and function of T cells in mice with a disrupted CD2 gene.

1992 • 134 citations

Helper T-cell development in the absence of CD4-p56 Ick association

1993 • 132 citations

MHC control of CD4+ T cell subset activation.

1989 • 121 citations

Involvement of both major histocompatibility complex class II alpha and beta chains in CD4 function indicates a role for ordered oligomerization in T cell activation.

1995 • 117 citations

Molecular analyses of the association of CD4 with two members of the transmembrane 4 superfamily, CD81 and CD82.

1995 • 115 citations

Involvement of specific Lyt‐2⁺ T cells in the immunological control of experimentally induced murine cutaneous leishmaniasis

1987 • 108 citations

An Easily Prepared Defined Medium for Cultivation of Leishmania donovani Promastigotes

1978 • 104 citations

Class II major histocompatibility complex‐restricted T cell function in CD4‐deficient mice

1994 • 102 citations

Selecting T Cell Receptors with High Affinity for Self-MHC by Decreasing the Contribution of CD8

1992 • 98 citations

Protection against Leishmania major in BALB/c mice by adoptive transfer of a T cell clone recognizing a low molecular weight antigen released by promastigotes.

1990 • 91 citations

Disruption of epithelial gamma delta T cell repertoires by mutation of the Syk tyrosine kinase.

1996 • 76 citations

Delineation of an extended surface contact area on human CD4 involved in class II major histocompatibility complex binding.

1993 • 74 citations

Preferential usage of the Fc receptor gamma chain in the T cell antigen receptor complex by gamma/delta T cells localized in epithelia.

1994 • 69 citations

The two membrane proximal domains of CD4 interact with the T cell receptor.

1996 • 69 citations

Demethylated CD8 Gene in CD4⁺T Cells Suggests that CD4⁺Cells Develop from CD8⁺Precursors

1988 • 68 citations

Thymocytes can become mature T cells without passing through the CD4+ CD8+, double-positive stage.

1996 • 63 citations

The gamma chain of the high-affinity receptor for IgE is a major functional subunit of the T-cell antigen receptor complex in gamma delta T lymphocytes.

1993 • 61 citations

MHC genotype controls the capacity of ligand density to switch T helper (Th)-1/Th-2 priming in vivo.

1996 • 56 citations

Inhibition or activation of human T cell receptor transfectants is controlled by defined, soluble antigen arrays.

1992 • 44 citations

Peptides corresponding to CD4-interacting regions of murine MHC class II molecules modulate immune responses of CD4+ T lymphocytes in vitro and in vivo.

1996 • 38 citations

Analysis of the contact sites on the CD4 molecule with class II MHC molecule: co-ligand versus co-receptor function.

1997 • 36 citations

Analysis of Immature (CD4–CD8–) Thymic Subsets in T-Cell Receptor αß Transgenic Mice

1992 • 22 citations

T cell development in TCR-alpha beta transgenic mice. Analysis using V(D)J recombination substrates.

1995 • 20 citations

Seeing double

1993 • 16 citations