Bioenergetics of neurotransmitter transport

The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation.

1962 • 2,522 citations

Glucose Transport in Isolated Brush Border Membrane from Rat Small Intestine

1973 • 841 citations

Role of Transmitter Uptake Mechanisms in Synaptic Neurotransmission

1971 • 768 citations

THE STRUCTURAL SPECIFICITY OF THE HIGH AFFINITY UPTAKE OF <scp>l</scp>‐GLUTAMATE AND <scp>l</scp>‐ASPARTATE BY RAT BRAIN SLICES

1972 • 694 citations

Effects of potassium, veratridine, and scorpion venom on calcium accumulation and transmitter release by nerve terminals in vitro.

1975 • 559 citations

THE UPTAKE OF [³H]GABA BY SLICES OF RAT CEREBRAL CORTEX

1968 • 543 citations

Uptake of Catecholamines by a Particulate Fraction of the Adrenal Medulla

1962 • 510 citations

GABA in Nervous System Function

1977 • 503 citations

SODIUM‐DEPENDENT, HIGH AFFINITY CHOLINE UPTAKE

1978 • 420 citations

Blood platelets as a model for monoamine-containing neurones

1973 • 407 citations

Membrane potentials in pinched‐off presynaptic nerve ternimals monitored with a fluorescent probe: evidence that synaptosomes have potassium diffusion potentials.

1975 • 389 citations

Studies of the uptake of3H-GABA and [3H]glycine in slices and homogenates of rat brain and spinal cord by electron microscopic autoradiography

1972 • 371 citations

CATECHOLAMINE UPTAKE PROCESSES

1973 • 344 citations

Active transport of L-glutamate by membrane vesicles isolated from rat brain

1978 • 334 citations

Inhibition of the uptake of tritiated 5-hydroxytryptamine in brain tissue

1969 • 321 citations

Transport Studies in Bacterial Membrane Vesicles

1974 • 301 citations

[47] Isolation of synaptosomal and synaptic plasma membrane fractions

1974 • 295 citations

Unique High Affinity Uptake Systems for Glycine, Glutamic and Aspartic Acids in Central Nervous Tissue of the Rat

1971 • 295 citations

The mechanism of neuronal and extraneuronal transport of catecholamines

1976 • 279 citations

The effects of changes in internal ionic concentrations on the electrical properties of perfused giant axons

1962 • 260 citations

Active transport of γ-aminobutyric acid by membrane vesicles isolated from rat brain

1978 • 253 citations

Specific tricyclic antidepressant binding sites in rat brain characterised by high-affinity 3H-imipramine binding

1980 • 249 citations

Internal pH of isolated chromaffin vesicles.

1976 • 238 citations

Active proton uptake by chromaffin granules: observation by amine distribution and phosphorus-31 nuclear magnetic resonance techniques

1977 • 230 citations

Active transport of 5-hydroxytryptamine by plasma membrane vesicles isolated from human blood platelets.

1977 • 224 citations

Potassium Migration and Amino Acid Transport

1958 • 223 citations

Neurotransmitter uptake: A tool in identifying neurotransmitter-specific pathways

1973 • 219 citations

Neurotoxin binding to receptor sites associated with voltage-sensitive sodium channels in intact, lysed, and detergent-solubilized brain membranes.

1979 • 214 citations

Protonmotive force and catecholamine transport in isolated chromaffin granules.

1979 • 192 citations

Binding order of substrates to the (sodium + potassium ion)-coupled L-glutamic acid transporter from rat brain

1982 • 184 citations

Stimulus‐secretion coupling processes in brain: analysis of noradrenaline and gamma‐aminobutyric acid release.

1976 • 183 citations

RESPIRATION IN VITRO OF SYNAPTOSOMES FROM MAMMALIAN CEREBRAL CORTEX

1969 • 181 citations

SYNAPTOSOMAL TRANSPORT: A CHLORIDE DEPENDENCE FOR CHOLINE, GABA, GLYCINE AND SEVERAL OTHER COMPOUNDS

1978 • 178 citations

Betel nut constituents as inhibitors of γ-aminobutyric acid uptake

1975 • 175 citations

ON THE ISOLATION OF NERVE ENDINGS AND SYNAPTIC VESICLES

1961 • 168 citations

The mechanism of Na+-dependent D-glucose transport.

1980 • 168 citations

Ultrastructural Localization of 5-Hydroxy-tryptamine in Blood Platelets

1966 • 163 citations

Coupling between platelet 5-hydroxytryptamine and potassium transport.

1979 • 160 citations

Glutamate uptake by brain slices and its relation to the depolarization of neurones by acidic amino acids

1972 • 154 citations

Electron transfer across the chromaffin granule membrane.

1983 • 148 citations

Sodium‐dependent accumulation of 5‐hydroxytryptamine by rat blood platelets

1969 • 145 citations

Mechanism of imipramine inhibition of platelet 5-hydroxytryptamine transport.

1979 • 139 citations

Role of Mg²⁺ion-activated ATPase and a pH gradient in the storage of catecholamines in synaptic vesicles

1978 • 135 citations

Proton gradient linkage to active uptake of [3H]acetylcholine by Torpedo electric organ synaptic vesicles

1982 • 135 citations

KINETICS OF THE SODIUM‐DEPENDENT TRANSPORT OF GAMMA‐AMINOBUTYRIC ACID BY SYNAPTOSOMES

1973 • 133 citations

THE ADENOSINE-TRIPHOSPHATASE ACTIVITY OF ADRENAL CHROMAFFIN GRANULES

1965 • 132 citations

Active amino acid transport in plasma membrane vesicles from Simian virus 40-transformed mouse fibroblasts. Characteristics of electrochemical Na+ gradient-stimulated uptake.

1977 • 132 citations

IONS AND THE TRANSPORT OF GAMMA‐AMINOBUTYRIC ACID BY SYNAPTOSOMES

1972 • 131 citations

Stoichiometry of sodium- and chloride-coupled .gamma.-aminobutyric acid transport by synaptic plasma membrane vesicles isolated from rat brain

1983 • 127 citations

.gamma.-Aminobutyric acid agonists, antagonists, and uptake inhibitors. Design and therapeutic aspects

1981 • 124 citations

COUPLED TRANSPORT OF GLUTAMATE AND SODIUM IN A CEREBELLAR NERVE CELL LINE

1979 • 122 citations

The Feldberg Lecture 1976. Solute transport across epithelia: what can we learn from micropuncture studies in kidney tubules?

1979 • 120 citations

High-affinity [3H]desipramine binding in the peripheral and central nervous system: A specific site associated with the neuronal uptake of noradrenaline

1982 • 120 citations

The effects of potassium and membrane potential on sodium-dependent glutamic acid uptake

1980 • 119 citations

Coupling of transmembrane proton gradients to platelet serotonin transport.

1982 • 119 citations

Tetrodotoxin Does Not Block Excitation from Inside the Nerve Membrane

1966 • 115 citations

Proton-Linked Transport in Chromaffin Granules1 1Abbreviations: Δψ, transmembrane potential; ΔpH+, transmembrane pH gradient; ΔμH+ proton motive force, = Δψ - [2.3RT/F]ΔpH; ATPase, adenosine triphosphatase; DCCD, N,N′-dicyclohexylcarbodiimide; DNP, 2,4-dinitrophenol; FCCP, carbonyl cyanide p-trifluoromethoxyphenyl hydrazone; L-DOPA, L-dihydroxyphenylalanine; Nbf-Cl, 4-chloro-7-nitrobenzofurazan; NMR, nuclear magnetic resonance; S-13, 5-chloro-3-tert-butyl-2′-chloro-4-nitrosalicylanilide.

1981 • 115 citations

Active transport in membrane vesicles from Escherichia coli: the electrochemical proton gradient alters the distribution of the lac carrier between two different kinetic states

1980 • 115 citations

A novel ATPase in the chromaffin granule membrane.

1983 • 114 citations

deltapH and catecholamine distribution in isolated chromaffin granules.

1978 • 111 citations

Platelet 5-hydroxytryptamine transport, an electroneutral mechanism coupled to potassium

1978 • 108 citations

Storage of dopamine and acetylcholine in granules of PC12, a clonal pheochromocytoma cell line

1980 • 107 citations

Neurochemical correlates of synaptically active amino acids

1974 • 107 citations

An Adenosine Triphosphatase Isolated from Chromaffin-Granule Membranes is Closely Similar to F1-Adenosine Triphosphatase of Mitochondria

1979 • 106 citations

Sodium gradient-dependent L-glutamate transport in renal brush border membrane vesicles. Effect of an intravesicular &gt; extravesicular potassium gradient.

1980 • 103 citations

RAPID EFFECTS OF VERATRIDINE, TETRODOTOXIN, GRAMICIDIN D, VALINOMYCIN AND NaCN ON THE NA⁺, K⁺ AND ATP CONTENTS OF SYNAPTOSOMES

1977 • 102 citations

Measurement of delta pH and membrane potential in isolated neurosecretory vesicles from bovine neurohypophyses.

1981 • 100 citations

Influence of membrane potential on the sodium-dependent uptake of gamma-aminobutyric acid by presynaptic nerve terminals: Experimental observations and theoretical considerations

1976 • 98 citations

Solubilization of the platelet plasma membrane serotonin transporter in an active form.

1980 • 97 citations

Transport of catecholamines by resealed chromaffin-granule ‘ghosts’

1974 • 94 citations

The serotonin transporter-imipramine "receptor".

1983 • 94 citations

Sodium channels in presynaptic nerve terminals. Regulation by neurotoxins.

1980 • 93 citations

[3H]GABA uptake as a marker for cell type in primary cultures of cerebellum and olfactory bulb

1980 • 93 citations

A reevaluation of veratridine as a tool for studying the depolarization-induced release of neurotransmitters from nerve endings

1980 • 93 citations

The internal pH of mast cell granules

1980 • 92 citations

Proton: substrate stoichiometries during active transport of biogenic amines in chromaffin ghosts.

1981 • 90 citations

The role of chloride ion in platelet serotonin transport.

1982 • 90 citations

The effect of d-glucose on the electrical potential profile across the proximal tubule of newt kidney

1972 • 87 citations

Biological amine transport in chromaffin ghosts. Coupling to the transmembrane proton and potential gradients.

1979 • 87 citations

Serotonin transport in isolated platelet granules. Coupling to the electrochemical proton gradient.

1981 • 86 citations

Transport of d-glucose by brush border membranes isolated from the renal cortex

1974 • 86 citations

The internal pH of isolated serotonin containing granules of pig platelets.

1978 • 84 citations

Sodium gradient-dependent L-glutamate transport in renal brush border membrane vesicles. Evidence for an electroneutral mechanism.

1980 • 82 citations

Stoichiometry of hydrogen ion-linked dopamine transport in chromaffin granule ghosts

1981 • 81 citations

A potassium ion diffusion potential causes adrenaline uptake in chromaffin-granule ‘ghosts’

1979 • 80 citations

Glycine transport into plasma-membrane vesicles derived from rat brain synaptosomes

1981 • 79 citations

Electrogenic epinephrine transport in chromaffin granule ghosts

1980 • 74 citations

Energetics of gamma-aminobutyrate transport in rat brain synaptosomes.

1982 • 74 citations

Reserpine as a competitive and reversible inhibitor of the catecholamine transporter of bovine chromaffin granules

1979 • 73 citations

The stimulus‐induced release of acetylcholine from synaptosome beds and its calcium dependence

1972 • 73 citations

Biochemical studies of synapses in vitro. II. Potassium transport

1969 • 72 citations

Evidence for two distinct serotonin transport systems in platelets.

1980 • 72 citations

The role of internal and external Na+ and K+ on the uptake of [3H]noradrenaline by synaptosomes prepared from rat brain

1970 • 70 citations

The effect of uncouplers on catecholamine incorporation by vesicles of chromaffin granules

1975 • 69 citations

Determination of ΔpH in cholinergic synaptic vesicles: Its effect on storage and release of acetylcholine

1980 • 68 citations

ATP‐dependent proton translocation in resealed chromaffin granule ghosts

1977 • 67 citations

Proton-translocating Mg2+-dependent ATPase activity in insulin-secretory granules

1982 • 67 citations

Identification of GABA neurons in rat cortical cultures by GABA uptake autoradiography

1980 • 67 citations

The membrane of catecholamine storage vesicles of adrenal medulla catecholamine fluxes and ATPase activity

1971 • 65 citations

GABA efflux from synaptosomes: Effects of membrane potential, and external GABA and cations

1982 • 64 citations

Bioenergetics of serotonin transport by membrane vesicles derived from platelet dense granules.

1982 • 64 citations

Hydroxytryptamine transport by the bovine chromaffin-granule membrane

1978 • 62 citations

Energy‐linked activities of the chromaffin granule membrane

1975 • 62 citations

The Relative Role of Recapture and of de novo Synthesis for the Maintenance of Neurotransmitter Homeostasis in Noradrenergic Nerves

1969 • 62 citations

STUDIES ON SODIUM TRANSPORT IN RAT BRAIN NERVE‐ENDING PARTICLES

1968 • 59 citations

Efflux of L-glutamate by synaptic plasma membrane vesicles isolated from rat brain

1982 • 59 citations

‘High affinity’ binding of [3H] desipramine to rat cerebral cortex: Relationship to tricyclic antidepressant-induced inhibition of norepinephrine uptake

1981 • 59 citations

pH‐Dependence of the ATP‐Driven Uptake of Noradrenaline by Bovine Chromaffin‐Granule Ghosts

1981 • 56 citations

Regional differences in the synaptosomal uptake of 3H-gamma-aminobutyric acid and 14C-glutamate and possible role of exchange processes.

1974 • 55 citations

Anion effects on glycine entry into pigeon red blood cells

1972 • 55 citations

Amine transport in chromaffin granule ghosts. pH dependence implies cationic form is translocated.

1981 • 54 citations

[3H]Desipramine and [3H]imipramine binding are not associated with noradrenaline and serotonin uptake in the brain

1982 • 52 citations

Transport of <scp>l</scp>‐Aspartate and <scp>l</scp>‐Glutamate in Plasma‐Membrane Vesicles from Rat Liver

1982 • 52 citations

The dependence of glutamate uptake by crab nerve on external Na+ and K+

1971 • 51 citations

Direct measurement of lactose/proton symport in Escherichia coli membrane vesicles: further evidence for the involvement of a histidine residue(s)

1982 • 50 citations

Isolation and characterization of an organic solvent soluble polypeptide component from photoreceptor complexes of Rhodospirillum rubrum

1977 • 50 citations

Na+-Dependent amino acid transport in plasma membrane vesicles from ehrlich ascites cells

1974 • 49 citations

The role of a transmembrane pH gradient in 5‐hydroxy tryptamine uptake by synaptic vesicles from rat brain

1979 • 49 citations

A major role for chloride in (3H)- noradrenaline transport by rat heart adrenergic nerves

1977 • 49 citations

Solubilization and reconstitution of the catecholamine transporter from bovine chromaffin granules

1979 • 48 citations

Both the transmembrane pH gradient and the membrane potential are important in the accumulation of amines by resealed chromaffin‐granule ‘ghosts’

1980 • 48 citations

Functional asymmetry of the amine transporter from chromaffin granules.

1983 • 48 citations

NET UPTAKE OF L‐GLUTAMATE AND GABA BY HIGH AFFINITY SYNAPTOSOMAL TRANSPORT SYSTEMS

1978 • 48 citations

Net uptake of gamma-aminobutyric acid by a high affinity synaptosomal transport system.

1977 • 47 citations

Mucate Inhibition of Glycine Entry into Pigeon Red Cells^*

1964 • 47 citations

Uptake of Serotonin in Blood Platelets in vitro. I: The Effects of Chloride

1971 • 47 citations

Modulation of neurotransmitter transport by the activity of the action potential sodium ion channel in membrane vesicles from rat brain

1980 • 46 citations

L‐Aspartate Transport into Plasma Membrane Vesicles Derived from Rat Brain Synaptosomes

1981 • 44 citations

A model of GABA transport by cortical synaptosomes from the long‐evans rat

1979 • 43 citations

Sodium channel, sodium pump, and sodium-calcium exchange activities in synaptosomal plasma membrane vesicles.

1982 • 43 citations

A MODEL OF HIGH AFFINITY GLUTAMIC ACID TRANSPORT BY RAT CORTICAL SYNAPTOSOMES–A REFINEMENT OF THE ORIGINALLY PROPOSED MODEL

1979 • 42 citations

SODIUM AND POTASSIUM IONS AND ACCUMULATION OF LABELLED d-ASPARTATE AND GABA IN CRUDE SYNAPTOSOMAL FRACTION FROM RAT CEREBRAL CORTEX

1978 • 42 citations

Efflux and exchange of γ-aminobutyric acid and nipecotic acid catalysed by synaptic plasma membrane vesicles isolated from immature rat brain

1983 • 42 citations

Selective uptake of [3H]γ-aminobutyrate by rat supra- and subependymal nerve fibers, histological and high resolution radioautographic studies

1980 • 42 citations

Solubilisation and reconstitution of the γ-aminobutyric acid transporter from rat brain

1978 • 41 citations

Efflux of .gamma.-aminobutyric acid by synaptic plasma membrane vesicles isolated from rat brain

1981 • 41 citations

Mechanism of lactose transport in Escherichia coli membrane vesicles: evidence for the involvement of a histidine residue(s) in the response of the lac carrier to the proton electrochemical gradient

1982 • 41 citations

Participation of a transmembrane proton gradient in 5-hydroxytryptamine transport by platelet dense granules and dense-granule ghosts

1981 • 40 citations

Active and passive transport of dopamine in chromaffin granule ghosts isolated from bovine adrenal medulla.

1979 • 40 citations

Solubilization and reconstitution of the L‐glutamic acid transporter from rat brain

1978 • 39 citations

Electrogenic transport of biogenic amines in chromaffin granule membrane vesicles

1980 • 39 citations

Effects of polyvalent cations on stimulus-coupled secretion of (14C)-gamma-aminobutyric acid from isolated brain synaptosomes.

1974 • 39 citations

Choline and acetylcholine metabolism in PC12 secretory cells

1981 • 38 citations

Glutamate, aspartate, and γ-aminobutyrate transport by membrane vesicles prepared from rat brain

1981 • 38 citations

Photoinactivation and identification of the biogenic amine transporter in chromaffin granules from bovine adrenal medulla.

1982 • 38 citations

Role of the proton electrochemical gradient in monoamine transport by bovine chromaffin granules

1980 • 36 citations

A chloride requirement for Na+-dependent amino-acid transport by brush border membrane vesicles isolated from the intestine of a mediterranean teleost (Boops salpa)

1981 • 34 citations

The effect of a cross-bridging thiol reagent on the catecholamine fluxes of adrenal medulla vesicles

1970 • 34 citations

High-Affinity Choline Transport in Proteoliposomes Derived from Rat Cortical Synaptosomes

1982 • 33 citations

Active transport of l-proline by membrane vesicles isolated from rat brain

1980 • 32 citations

Functional membrane vesicles from the nervous system of insects

1982 • 31 citations

Proline transport by synaptosomal membrane vesicles isolated from rat brain: energetics and inhibition by free fatty acids

1982 • 28 citations

Transport of Catecholamines by Native and Reconstituted Rat Heart Synaptic Vesicles

1980 • 27 citations

Uptake and Exchange of GABA and Glutamate in Isolated Nerve Endings

1976 • 26 citations

Multiple effects of reserpine on chromaffin-granule membranes

1982 • 25 citations

Reconstitution of 5-hydroxytryptamine transport from cholate-disrupted platelet plasma membrane vesicles

1978 • 24 citations

Comparison of DABA and GABA Transport into Plasma Membrane Vesicles Derived from Synaptosomes

1981 • 24 citations

Transport of 5-hydroxytryptamine by dense granules from porcine platelets.

1978 • 23 citations

Net uptake of aspartate by a high-affinity rat cortical synaptosomal transport system

1979 • 22 citations

SYNAPTIC VESICLES ISOLATED FROM RAT HEART: l‐[³H]NOREPINEPHRINE UPTAKE PROPERTIES¹

1979 • 21 citations

Accumulation of [³H]ATP in small dense core vesicles of superfused vasa deferentia

1979 • 20 citations

Magnesium-dependent ATP-ase in membranes of 5-hydroxytryptamine storage organelles

1972 • 20 citations

The effect of chlorpromazine on bioenergetic processes in chromaffin granule membranes

1979 • 18 citations

Effect of diethylpyrocarbonate on pH‐driven monoamine uptake by chromaffin granule ghosts

1981 • 17 citations

L-glutamate transport in renal plasma membrane vesicles

1981 • 16 citations

Kinetic Features of Cotransport Mechanisms Under Isotope Exchange Conditions

1981 • 15 citations

Competitive Inhibition of γ‐Aminobutyric Acid Synaptosomal Uptake by 4‐(4′‐Azidobenzoimidylamino)butanoic Acid

1982 • 7 citations