Acute Formation of Protease-resistant Prion Protein Does Not Always Lead to Persistent Scrapie Infection in Vitro

Novel Proteinaceous Infectious Particles Cause Scrapie

1982 • 4,972 citations

Mice devoid of PrP are resistant to scrapie

1993 • 2,058 citations

Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD

1996 • 1,740 citations

A cellular gene encodes scrapie PrP 27-30 protein

1985 • 1,494 citations

Identification of a Protein That Purifies with the Scrapie Prion

1982 • 1,260 citations

Eight prion strains have PrPSc molecules with different conformations

1998 • 1,236 citations

Cell-free formation of protease-resistant prion protein

1994 • 872 citations

Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein

1995 • 835 citations

Non-genetic propagation of strain-specific properties of scrapie prion protein

1995 • 517 citations

Distinct prion proteins in short and long scrapie incubation period mice

1987 • 482 citations

Scrapie-infected murine neuroblastoma cells produce protease-resistant prion proteins

1988 • 366 citations

A quantitative, highly sensitive cell-based infectivity assay for mouse scrapie prions

2003 • 319 citations

Strain-dependent Differences in β-Sheet Conformations of Abnormal Prion Protein

1998 • 313 citations

Abnormal isoform of prion protein accumulates in follicular dendritic cells in mice with Creutzfeldt-Jakob disease

1991 • 290 citations

A hypothalamic neuronal cell line persistently infected with scrapie prions exhibits apoptosis

1997 • 279 citations

Asparagine-linked glycosylation of the scrapie and cellular prion proteins

1989 • 268 citations

Conversion of raft associated prion protein to the protease-resistant state requires insertion of PrP-res (PrPSc) into contiguous membranes

2002 • 261 citations

Molecular assessment of the potential transmissibilities of BSE and scrapie to humans

1997 • 260 citations

Scrapie strain variation and mutation

1993 • 240 citations

Successful Transmission of Three Mouse-Adapted Scrapie Strains to Murine Neuroblastoma Cell Lines Overexpressing Wild-Type Mouse Prion Protein

2000 • 234 citations

Sulfated glycans and elevated temperature stimulate PrPSc-dependent cell-free formation of protease-resistant prion protein

2001 • 231 citations

Replication of distinct scrapie prion isolates is region specific in brains of transgenic mice and hamsters.

1992 • 213 citations

Prion infection impairs the cellular response to oxidative stress

2000 • 213 citations

Selective Neuronal Targeting in Prion Disease

1997 • 206 citations

Characterization of Scrapie Infection in Mouse Neuroblastoma Cells

1987 • 199 citations

Cyclic amplification of protein misfolding: application to prion-related disorders and beyond

2002 • 168 citations

Scrapie strains maintain biological phenotypes on propagation in a cell line in culture

2001 • 151 citations

Heparin‐like molecules bind differentially to prion‐proteins and change their intracellular metabolic fate

1993 • 140 citations

Cellular Heparan Sulfate Participates in the Metabolism of Prions

2003 • 135 citations

Transfer of Scrapie Prion Infectivity by Cell Contact in Culture

2002 • 134 citations

Distinct profiles of PrPd immunoreactivity in the brain of scrapie- and BSE-infected sheep: implications for differential cell targeting and PrP processing

2003 • 121 citations

Susceptibility of Common Fibroblast Cell Lines to Transmissible Spongiform Encephalopathy Agents

2004 • 119 citations

Competition between Different Scrapie Agents in Mice

1972 • 111 citations

Molecular location of a species-specific epitope on the hamster scrapie agent protein

1991 • 101 citations

Localization of the mRNA for a chicken prion protein by in situ hybridization.

1993 • 90 citations

Molecular Basis of Scrapie Strain Glycoform Variation

2002 • 76 citations

Prion Rods Contain an Inert Polysaccharide Scaffold

1999 • 66 citations

Expression of unglycosylated mutated prion protein facilitates PrPSc formation in neuroblastoma cells infected with different prion strains

2000 • 64 citations

Purification and Partial Characterization of the Normal Cellular Homologue of the Scrapie Agent Protein

1988 • 47 citations

Nucleic acid binding proteins in highly purified Creutzfeldt-Jakob disease preparations.

1993 • 37 citations

Demonstration of scrapie strain diversity in infected PC12 cells

1992 • 31 citations

Strain-specific Kinetics of Prion Protein Formation in Vitro and in Vivo

2004 • 21 citations