Cyclic amplification of protein misfolding: application to prion-related disorders and beyond

Prions

1998 • 5,102 citations

Molecular Chaperones in the Cytosol: from Nascent Chain to Folded Protein

2002 • 3,280 citations

Seeding “one-dimensional crystallization” of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?

1993 • 2,146 citations

Mice devoid of PrP are resistant to scrapie

1993 • 2,058 citations

Protein misfolding, evolution and disease

1999 • 1,948 citations

Dynamic Brain Sources of Visual Evoked Responses

2002 • 1,610 citations

Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding

2001 • 1,228 citations

Anticipatory Biasing of Visuospatial Attention Indexed by Retinotopically Specific α-Bank Electroencephalography Increases over Occipital Cortex

2000 • 1,220 citations

Scrapie prions aggregate to form amyloid-like birefringent rods

1983 • 1,048 citations

Cell-free formation of protease-resistant prion protein

1994 • 872 citations

Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein

1995 • 835 citations

Conformational disease

1997 • 794 citations

On the nucleation and growth of amyloid beta-protein fibrils: detection of nuclei and quantitation of rate constants.

1996 • 773 citations

Synchronization between prefrontal and posterior association cortex during human working memory

1998 • 732 citations

Top-down processing mediated by interareal synchronization

2000 • 725 citations

Tissue distribution of protease resistant prion protein in variant Creutzfeldt-Jakob disease using a highly sensitive immunoblotting assay

2001 • 696 citations

Alternative conformations of amyloidogenic proteins govern their behavior

1996 • 596 citations

Imaging brain dynamics using independent component analysis

2001 • 558 citations

Defective protein folding as a basis of human disease

1995 • 540 citations

PATHOLOGIC CONFORMATIONS OF PRION PROTEINS

1998 • 531 citations

Species specificity in the cell-free conversion of prion protein to protease-resistant forms: a model for the scrapie species barrier.

1995 • 343 citations

Protein misfolding and disease; protein refolding and therapy

2001 • 335 citations

From the cradle to the grave: molecular chaperones that may choose between folding and degradation

2001 • 328 citations

Oscillatory Neuronal Synchronization in Primary Visual Cortex as a Correlate of Stimulus Selection

2002 • 313 citations

Structural and kinetic features of amyloid β-protein fibrillogenesis

1998 • 278 citations

Quantifying the kinetic parameters of prion replication

1999 • 237 citations

Inhibition of protease-resistant prion protein formation by porphyrins and phthalocyanines

1998 • 236 citations

Prion Protein Amyloidosis

1996 • 190 citations

Specific Inhibition of in Vitro Formation of Protease-resistant Prion Protein by Synthetic Peptides

1998 • 179 citations

BSE and Prions: Uncertainties About the Agent

1998 • 177 citations

Interactions between heterologous forms of prion protein: Binding, inhibition of conversion, and species barriers

2000 • 168 citations

Mad Cows Meet Psi-chotic Yeast: The Expansion of the Prion Hypothesis

1997 • 160 citations

Blood infectivity and the prospects for a diagnostic screening test in Creutzfeldt-Jakob disease

2001 • 135 citations

Scrapie infectivity correlates with converting activity, protease resistance, and aggregation of scrapie-associated prion protein in guanidine denaturation studies

1997 • 122 citations

Protein Misfolding and Disease

2003 • 113 citations

Prions of Yeast and Fungi

1999 • 80 citations

Alzheimer's and prion disease as disorders of protein conformation: implications for the design of novel therapeutic approaches

1999 • 75 citations

Cell-Lysate Conversion of Prion Protein into Its Protease-Resistant Isoform Suggests the Participation of a Cellular Chaperone

1999 • 69 citations

Pathology of the transmissible spongiform encephalopathies with special emphasis on ultrastructure

1995 • 66 citations

Prions: disease propagation and disease therapy by conformational transmission

2001 • 53 citations

Prion diseases, blood and the immune system: concerns and reality.

2000 • 52 citations

Putting Prions to the Test

1996 • 47 citations

The measured level of prion infectivity varies in a predictable way according to the aggregation state of the infectious agent

2001 • 28 citations

Testing times for BSE

2001 • 23 citations