Strain-specific Kinetics of Prion Protein Formation in Vitro and in Vivo

Guide for the Care and Use of Laboratory Animals

2011 • 15,863 citations

Novel Proteinaceous Infectious Particles Cause Scrapie

1982 • 4,972 citations

Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins.

1993 • 2,237 citations

Seeding “one-dimensional crystallization” of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?

1993 • 2,146 citations

Molecular Biology of Prion Diseases

1991 • 1,978 citations

Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD

1996 • 1,740 citations

Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding

2001 • 1,228 citations

Nature of the Scrapie Agent: Self-replication and Scrapie

1967 • 1,128 citations

Scrapie prions aggregate to form amyloid-like birefringent rods

1983 • 1,048 citations

Cell-free formation of protease-resistant prion protein

1994 • 872 citations

Secondary structure analysis of the scrapie-associated protein PrP 27-30 in water by infrared spectroscopy

1991 • 812 citations

Distinct PrP properties suggest the molecular basis of strain variation in transmissible mink encephalopathy

1994 • 663 citations

Separation and properties of cellular and scrapie prion proteins.

1986 • 619 citations

Non-genetic propagation of strain-specific properties of scrapie prion protein

1995 • 517 citations

Abnormal fibrils from scrapie-infected brain

1981 • 473 citations

Biochemical and physical properties of the prion protein from two strains of the transmissible mink encephalopathy agent

1992 • 440 citations

Reversible Conversion of Monomeric Human Prion Protein Between Native and Fibrilogenic Conformations

1999 • 368 citations

Strain-dependent Differences in β-Sheet Conformations of Abnormal Prion Protein

1998 • 313 citations

Fatal familial insomnia and familial Creutzfeldt-Jakob disease: different prion proteins determined by a DNA polymorphism.

1994 • 311 citations

Abnormal isoform of prion protein accumulates in follicular dendritic cells in mice with Creutzfeldt-Jakob disease

1991 • 290 citations

Identification of two biologically distinct strains of transmissible mink encephalopathy in hamsters

1992 • 276 citations

First-order kinetic model of Alzheimer's beta-amyloid fibril extension in vitro.

1996 • 244 citations

PrP protein is associated with follicular dendritic cells of spleens and lymph nodes in uninfected and scrapie‐infected mice

1992 • 224 citations

Kinetic analysis of amyloid fibril polymerization in vitro.

1991 • 190 citations

Aggregates of scrapie-associated prion protein induce the cell-free conversion of protease-sensitive prion protein to the protease-resistant state

1995 • 188 citations

Transmissible and non-transmissible amyloidoses: autocatalytic post-translational conversion of host precursor proteins to β-pleated sheet configurations

1988 • 155 citations

Alternative Prion Structural Changes Revealed by High Pressure

2003 • 88 citations

Species-Independent Inhibition of Abnormal Prion Protein (PrP) Formation by a Peptide Containing a Conserved PrP Sequence

1999 • 83 citations

Copurification of Sp33-37 and Scrapie Agent from Hamster Brain Prior to Detectable Histopathology and Clinical Disease

1991 • 70 citations

Retrograde Transport of Transmissible Mink Encephalopathy within Descending Motor Tracts

2002 • 68 citations

Reversibility of Scrapie-associated Prion Protein Aggregation

2001 • 42 citations