Molecular assessment of the potential transmissibilities of BSE and scrapie to humans

A new variant of Creutzfeldt-Jakob disease in the UK

1996 • 2,690 citations

Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD

1996 • 1,740 citations

Identification of a Protein That Purifies with the Scrapie Prion

1982 • 1,260 citations

NMR structure of the mouse prion protein domain PrP(121–231)

1996 • 1,251 citations

Cell-free formation of protease-resistant prion protein

1994 • 872 citations

Homozygous prion protein genotype predisposes to sporadic Creutzfeldt–Jakob disease

1991 • 871 citations

Mouse polyclonal and monoclonal antibody to scrapie-associated fibril proteins

1987 • 757 citations

Transmission dynamics and epidemiology of BSE in British cattle

1996 • 601 citations

Non-genetic propagation of strain-specific properties of scrapie prion protein

1995 • 517 citations

PrP Genotype and Agent Effects in Scrapie: Change In Allelic Interaction With Different Isolates of Agent in Sheep, a Natural Host of Scrapie

1994 • 440 citations

Species specificity in the cell-free conversion of prion protein to protease-resistant forms: a model for the scrapie species barrier.

1995 • 343 citations

The major polypeptide of scrapie-associated fibrils (SAF) has the same size, charge distribution and N-terminal protein sequence as predicted for the normal brain protein (PrP).

1986 • 322 citations

Transmission of bovine spongiform encephalopathy to sheep and goats

1993 • 296 citations

Fibrils from brains of cows with new cattle disease contain scrapie-associated protein

1988 • 233 citations

Immumohistochemical Detection and Localization of Prion Protein in Brain Tissue of Sheep With Natural Scrapie

1995 • 202 citations

Aggregates of scrapie-associated prion protein induce the cell-free conversion of protease-sensitive prion protein to the protease-resistant state

1995 • 188 citations

Scrapie susceptibility-linked polymorphisms modulate the in vitro conversion of sheep prion protein to protease-resistant forms

1997 • 174 citations

Molecular biology of transmissible spongiform encephalopathies

1996 • 171 citations

Unaltered susceptibility to BSE in transgenic mice expressing human prion protein

1997 • 170 citations

Prion protein and the transmissible spongiform encephalopathies

1997 • 168 citations

Effect of the D178N Mutation and the Codon 129 Polymorphism on the Metabolism of the Prion Protein

1996 • 143 citations

Transmission of bovine spongiform encephalopathy to mice

1988 • 122 citations

Scrapie infectivity correlates with converting activity, protease resistance, and aggregation of scrapie-associated prion protein in guanidine denaturation studies

1997 • 122 citations

Preliminary evidence of the experimental transmissibility of bovine spongiform encephalopathy to cattle.

1990 • 72 citations

In Situ Formation of Protease-resistant Prion Protein in Transmissible Spongiform Encephalopathy-infected Brain Slices

1997 • 52 citations

Methods for Studying Prion Protein (PrP) Metabolism and the Formation of Protease-Resistant PrP in Cell Culture and Cell-Free Systems

2003 • 4 citations