The design of rational combination chemotherapy for cancer.

DNA Glycosylases, Endonucleases for Apurinic/Apyrimidinic Sites, and Base Excision-Repair

1979 • 562 citations

Effect of Methotrexate Therapy upon Choriocarcinoma and Chorioadenoma

1956 • 493 citations

Enhanced 5-Fluorouracil Nucleotide Formation After Methotrexate Administration: Explanation for Drug Synergism

1979 • 251 citations

5-Fluorouracil incorporation into human breast carcinoma RNA correlates with cytotoxicity.

1981 • 187 citations

Rapid formation of poly-gamma-glutamyl derivatives of methotrexate and their association with dihydrofolate reductase as assessed by high pressure liquid chromatography in the Ehrlich ascites tumor cell in vitro.

1982 • 181 citations

The influence of methotrexate pretreatment on 5-fluorouracil metabolism in L1210 cells.

1981 • 138 citations

Cell killing studies on the mode of action of methotrexate on L-cells in vitro.

1969 • 132 citations

ON THE NATURE OF THYMINELESS DEATH

1971 • 94 citations

Perspectives on the design and biochemical pharmacology of inhibitors of thymidylate synthetase

1980 • 79 citations

The National Cancer Chemotherapy Program

1982 • 65 citations

Schedule-dependent cytotoxicity of methotrexate and 5-fluorouracil in human colon and breast tumor cell lines.

1980 • 59 citations

Optimal schedule of methotrexate and 5-fluorouracil in human breast cancer.

1982 • 57 citations

Tamoxifen and 5-fluorouracil in breast cancer: cytotoxic synergism in vitro.

1983 • 45 citations

Evaluation of ribonucleoside and deoxyribonucleoside triphosphate pools in cultured leukemia cells during exposure to methotrexate or methotrexate plus thymidine.

1979 • 43 citations

Effects of A-methopterin on the purine biosynthesis of susceptible and resistant TA3 ascites cells.

1958 • 18 citations

Alterations in the kinetics of methotrexate transport during growth of L1210 murine leukemia cells in culture.

1980 • 17 citations

Tight binding inhibitors—IX

1981 • 17 citations

Tamoxifen and 5-fluorouracil in breast cancer: modulation of cellular RNA.

1983 • 11 citations

Use of high-dose oral methotrexate sequenced at 24 hours with 5-FU: a clinical toxicity study.

1983 • 9 citations