Approaches to the Rational Combination of Antimetabolites for Cancer Chemotherapy

An Algorithm for Least-Squares Estimation of Nonlinear Parameters

1963 • 29,357 citations

On the nature of allosteric transitions: A plausible model

1965 • 8,699 citations

Semipermeable Microcapsules

1964 • 983 citations

Inhibition of mammalian DNA polymerase by the 5'-triphosphate of 1-beta-d-arabinofuranosylcytosine and the 5'-triphosphate of 9-beta-d-arabinofuranoxyladenine.

1968 • 477 citations

ANTAGONISTS OF NUCLEIC ACID DERIVATIVES

1954 • 427 citations

GENETIC STUDIES ON MICROBIAL CROSS RESISTANCE TO TOXIC AGENTS I. ,

1952 • 405 citations

Regulation of Mammalian Deoxyribonucleotide Biosynthesis by Nucleotides as Activators and Inhibitors

1966 • 395 citations

Specific Binding of 4-Amino Folic Acid Analogues by Folic Acid Reductase

1961 • 389 citations

Potentiation by inhibition of drug degradation : 6-substituted purines and xanthine oxidase

1963 • 305 citations

Studies of the enzymatic deamination of cytosine arabinoside—I

1965 • 296 citations

THE CHARACTERISTICS OF THE MEMBRANE TRANSPORT OF AMETHOPTERIN AND THE NATURALLY OCCURRING FOLATES

1971 • 291 citations

Inhibitor binding analysis of dihydrofolate reductases from various species.

1965 • 272 citations

Behavior of enzyme systems

1959 • 270 citations

ZONE BEHAVIOR OF ENZYMES

1943 • 235 citations

Treatment of leukemia with large doses of methotrexate and folinic acid: clinical-biochemical correlates

1969 • 234 citations

Relation of Folic Acid Reductase to Amethopterin Resistance in Cultured Mammalian Cells

1961 • 210 citations

Analytical description of the effects of modifiers and of enzyme multivalency upon the steady state catalyzed reaction rate

1953 • 192 citations

Fluorinated pyrimidines. XXVI. Mammalian thymidylate synthetase: its mechanism of action and inhibition by fluorinated nucleotides.

1965 • 192 citations

PYRIMIDINE METABOLISM

1956 • 178 citations

“Total therapy” studies of acute lymphocytic leukemia in children. Current results and prospects for cure

1972 • 159 citations

Potentiation of drug effect by Tween 80 in Chinese hamster cells resistant to actinomycin D and daunomycin.

1972 • 157 citations

THE BIOCHEMICAL, CELLULAR, AND PHARMACOLOGICAL ACTION AND EFFECTS OF THE FOLIC ACID ANTAGONISTS.

1963 • 156 citations

The in vivo Effects of Semipermeable Microcapsules containing L-Asparaginase on 6C3HED Lymphosarcoma

1971 • 146 citations

Inhibition of ribonucleoside diphosphate reductase by 1-formylisoquinoline thiosemicarbazone and related compounds

1970 • 141 citations

The Ability of Purine and Thymine Derivatives and of Glycine to Support the Growth of Mammalian Cells in Culture

1959 • 136 citations

Selected pharmacological testing methods

1968 • 130 citations

Cell synchrony : studies in biosynthetic regulation

1966 • 125 citations

The employment of combinations of drugs in the chemotherapy of neoplasia: a review.

1957 • 122 citations

Therapeutic efficacy of cyclophosphamide as a function of its metabolism.

1972 • 120 citations

The Use of Combinations of Antimicrobial Drugs

1968 • 118 citations

RELATIONSHIP BETWEEN METABOLIC FATES AND ANTITUMOR ACTIVITIES OF THIOPURINES.

1963 • 113 citations

Studies of the enzymatic deamination of ara-cytidine—V

1968 • 113 citations

Eradication Of Leukaemic Cells (L1210) by Methotrexate and Methotrexate Plus Citrovorum Factor

1966 • 112 citations

Identification of the enzymatic pathways of nucleotide metabolism in human lymphocytes and leukemia cells.

1973 • 111 citations

Chemotherapy of acute lymphocytic leukemia of childhood

1972 • 111 citations

Methotrexate therapy of head and neck cancer: improvement in therapeutic index by the use of leucovorin "rescue".

1970 • 110 citations

Sequential Blocking of Metabolic Pathways in vivo

1951 • 107 citations

Regulation of enzyme activity and allosteric interactions

1968 • 107 citations

Uptake as a Determinant of Methotrexate Response in Mouse Leukemias

1965 • 107 citations

Regulatory Mechanisms in Carbohydrate Metabolism

1959 • 103 citations

Biological approaches to cancer chemotherapy

1962 • 101 citations

Antagonisms and antagonists.

1957 • 101 citations

Synchronisation in vivo: Kinetics of a malignant cell system following temporary inhibition of DNA synthesis with hydroxyurea

1970 • 98 citations

Adriamycin and daunorubicin: a comparison of antitumor activities and tissue uptake in mice following immunosuppression.

1973 • 84 citations

Transport of Nitrogen Mustard on the Transport-Carrier for Choline in L5178Y Lymphoblasts

1971 • 81 citations

Augmentation of the incorporation of hypoxanthine into nucleic acids by the administration of an inhibitor of xanthine oxidase

1963 • 79 citations

Modification of tumor regression by immunologic means.

1969 • 79 citations

Purineless death as a link between growth rate and cytotoxicity by methotrexate.

1972 • 77 citations

Studies relating to the mode of action of methotrexate. II. Studies on sites of action in L-cells in vitro.

1969 • 72 citations

Enhancement by tetrahydrouridine of 1-beta-D-arabinofuranosylcytosine (cytarabine) oral activity in L1210 leukemic mice.

1970 • 70 citations

Cross Resistance and Collateral Sensitivity Studies in Cancer Chemotherapy

1963 • 68 citations

Drug Synergism in Antineoplastic Chemotherapy

1964 • 67 citations

Antigenicity of L1210 leukemic sublines induced by drugs.

1972 • 66 citations

Synthesis and biological activity of some new N6-substituted purine nucleosides

1969 • 63 citations

Principles of Drug Action. The Basis of Pharmacology.

1969 • 61 citations

Prevention of Toxicity of Amethopterin for Sarcoma-180 Cells in Tissue Culture

1957 • 61 citations

Effect of allopurinol on the pharmacokinetics of 6-mercaptopurine (NSC 755) in cancer patients.

1972 • 58 citations

Interaction of drugs inhibiting different steps in the synthesis of DNA.

1972 • 55 citations

Approaches to the Combination Chemotherapy of Transplantable Neoplasms

2015 • 52 citations

Xanthine as a precursor of nucleic acid purines in the mouse

1965 • 50 citations

The Conversion of Thymidine to Thymine Nucleotides and Deoxyribonucleic Acid in Vivo

1963 • 50 citations

Some approaches to the therapeutic exploitation of metabolic sites of vulnerability of neoplastic cells.

1969 • 50 citations

NEW APPROACHES TO CHEMOTHERAPY WITH FOLATE ANTAGONISTS: USE OF LEUCOVORIN “RESCUE” AND ENZYMIC FOLATE DEPLETION*

1971 • 49 citations

Stimulatory effects of inosine and deoxyinosine on the incorporation of uracil-2-14-C, 5-fluorouracil-2-14-C, and 5-bromouracil-2-14-C into nucleic acids by Ehrlich ascites tumor cells in vitro.

1969 • 49 citations

Attempts at dual blocking of biochemical events in cancer chemotherapy.

1954 • 48 citations

Adenosine kinase of sarcoma 180 cells N 6 -substituted adenosines as substrates and inhibitors.

1971 • 48 citations

Biochemical mechanisms for the synergism between 6-thioguanine and 6-(methylmercapto)purine ribonucleoside in sarcoma 180 cells.

1972 • 47 citations

Increased sensitivity of the Walker tumour towards aromatic nitrogen mustards carrying basic side chains following glucose pretreatment

1961 • 47 citations

Role of catabolism in pyrimidine utilization for nucleic acid synthesis in vivo.

1972 • 46 citations

Synergistic effect of 6-mercaptopurine and 6-methylmercaptopurine ribonucleoside on the levels of adenine nucleotides of Sarcoma 180 cells.

1972 • 46 citations

Combined sulphonylurea--biguanide therapy.

1969 • 45 citations

Mouse Kidney Cytidine Deaminase

1968 • 42 citations

Administration of 5-iododeoxyuridine-I-131 in the mouse and rat.

1961 • 41 citations

Regulatory Mechanisms in Carbohydrate Metabolism

1959 • 41 citations

RECENT ADVANCES IN ACUTE LEUKEMIA.

1964 • 40 citations

MATHEMATICAL SIMULATION IN CHEMOTHERAPY*

1971 • 39 citations

Some Inhibitors of Deamination of 9-β-d-Arabinofuranosyladenine and 9-β-d-Xylofuranosyladenine by Blood and Neoplasms of Experimental Animals and Humans

1968 • 39 citations

Interference with nucleoside transport in mouse lymphoma cells proliferating in culture.

1972 • 38 citations

Mechanism of the growth inhibition potentiation arising from combination of 6-mercaptopurine with 6-(methylmercapto)purine ribonucleoside.

1970 • 37 citations

Studies on the mechanism of inhibition of tumor growth by the enzyme glutaminase.

1966 • 37 citations

Drug resistance and selectivity. Biochemical and cellular basis

1975 • 37 citations

Therapeutic efficacy of cyclophosphamide as a function of inhibition of its metabolism.

1972 • 36 citations

Chemotherapy and comparative biochemistry: G. H. A. Clowes memorial lecture.

1969 • 34 citations

Irreversible inhibition of dehalogenation of 5-iodouracil by 5-diazouracil and reversible inhibition by 5-cyanouracil.

1970 • 33 citations

AN ANALYSIS OF THE LACK OF DRUG SYNERGISM DURING SEQUENTIAL BLOCKADE OF DE NOVO PYRIMIDINE BIOSYNTHESIS.

1964 • 33 citations

Studies on folic reductase. 3. The level of enzyme activity and response to methotrexate of transplantable mouse tumors.

1965 • 32 citations

Tetrahydrofolate Cofactors in Tissues Sensitive and Refractory to Amethopterin^*

1966 • 32 citations

Anti-Tumour and Biochemical Effects of Purified Bovine Xanthine Oxidase in C3H and C Mice

1958 • 30 citations

Sequential Blockage as a Theoretical Basis for Drug Synergism

1963 • 28 citations

Antitumor activity of a folate-cleaving enzyme, carboxypeptidase G 1 .

1972 • 28 citations

Active transport of nitrogen mustard and choline by normal and leukemic human lymphoid cells.

1972 • 27 citations

Antigenic differences between leukemia L1210 and a subline resistant to methylglyoxal-bis(guanylhydrazone).

1972 • 26 citations

Inhibition of Growth of Leukemia Cells by Enzymic Folate Depletion

1971 • 26 citations

Synchronisation in vivo: Temporary inhibition of DNA synthesis in the rat embryo with hydroxyurea

1971 • 24 citations

Coordinated changes in biochemical patterns: the effect of cytosine arabinoside and methotrexate on leukocytes from patients with acute granulocytic leukemia.

1969 • 24 citations

Mathematical simulation of the interaction of drugs that inhibit deoxyribonucleic acid biosynthesis.

1973 • 24 citations

Combination chemotherapy: synergistic inhibition of lymphoma L5178Y cells in culture and in vivo with 6-mercaptopurine and 6-(methylmercapto)purine ribonucleoside.

1969 • 23 citations

Prevention of the growth-inhibitory effect of 6-mercaptopurine by 4-amino-imidazole-5-carboxamide

1964 • 22 citations

Deamination of arabinosyladenine by adenosine deaminase and inhibition by arabinosyl-6-mercaptopurine.

1972 • 20 citations

Glutaminase induced prolonged regression of established Ehrlich carcinoma

1971 • 20 citations

Thymidine kinase as a determinant of the response to 5-fluoro-2'-deoxyuridine in transplantable murine leukemias.

1970 • 19 citations

Some observations on the phosphorylation of cytosine arabinoside.

1968 • 18 citations

Production of l-asparagine by tumor cells and the effect of asparagine analogs

1972 • 18 citations

Conference on obstacles to the control of acute leukemia. Studies on cross-resistance and collateral sensitivity (1962-1964).

1965 • 17 citations

The Combined Action of Pyrimidines and Sulfonamides or Sulfones in the Chemotherapy of Malaria and Other Protozoal Infections

1971 • 16 citations

Synergistic inhibitory action of a-methopterin and a diaminopyrimidine upon leukemia L1210 in mice.

1953 • 15 citations

Evaluation of combination chemotherapy in vivo and in culture with l- -D-arabinofuranosylcytosine and 1-formylisoquinoline thiosemicarbazone.

1972 • 15 citations

Collateral sensitivity of resistant lines of mouse leukemias L1210 and L5178Y.

1972 • 14 citations

Elevation of thymidylate synthetase activity in CCRF-CEM cells.

1971 • 14 citations

Scheduling of arabinosylcytosine and 6-thioguanine therapy.

1973 • 14 citations

The failure of allopurinol to enhance 6-mercaptopurine toxicity in rabbits.

1973 • 13 citations

Effects of uracil derivatives on phosphorylation of arabinosylcytosine.

1968 • 13 citations

The Employment of Methods of Inhibition Analysis in the Normal and Tumor-Bearing Mammalian Organism

1956 • 12 citations

Conference on obstacles to the control of acute leukemia. Formal discussion: some enzymatic considerations in combination chemotherapy.

1965 • 12 citations

Sparing action of uridine on the activity of arabinosylcytosine with normal and leukemic mice.

1968 • 12 citations

Antitumor activity of N6-phenyladenosine, and inhibitor of adenosine utilization, in combination with related purine analogs.

1973 • 11 citations

The prediction of growth-inhibitory drug combinations showing enhanced differential toxicity and collateral sensitivity.

1962 • 10 citations

Methotrexate and cytosine arabinoside modulation of thymidylate synthetase activity in CCRF-CEM cells.

1971 • 10 citations

Induction of the dihydrofolate reductase of Streptococcus faecium var. durans by folic and by some of its derivatives

1970 • 9 citations

The return of antimetabolite sensitivity in methotrexate- and 6-mercaptopurine-resistant L1210 murine leukemia by the process of adaptive selection.

1972 • 9 citations

Effect of Urease Injections on Ehrlich Ascites Tumor Growth in Mice

1972 • 8 citations

Combinations of drugs which interact as inhibitors of DNA biosynthesis

1972 • 7 citations

Combination chemotherapy: treatment of the Ehrlich ascites carcinoma and several drug-resistant sublines with combinations of 6-mercaptopurine and 6-(methylmercapto)purine ribonucleoside

1970 • 6 citations

Acridine Orange Potentiation of Actinomycin D Uptake and Activity

1971 • 5 citations

The synergistic effect of hypoglycemia and L-asparaginase upon transplantable hepatomas of varying growth rates.

1972 • 3 citations

Potentiation of Cell Growth Inhibition by Furanosides

1969 • 3 citations

Opening Remarks

1970 • 1 citations