Inhibition of vascular endothelial cell prostacyclin synthesis by plasmin

Arterial walls generate from prostaglandin endoperoxides a substance (prostaglandin X) which relaxes strips of mesenteric and coeliac arteries and inhibits platelet aggregation

1976 • 956 citations

Culture of vascular endothelium.

1976 • 532 citations

Synthesis of fibrinolytic activator and inhibitor by endothelial cells

1977 • 484 citations

Purification of an inhibitor of plasminogen activator (antiactivator) synthesized by endothelial cells.

1984 • 455 citations

Marked platelet activation in vivo after intravenous streptokinase in patients with acute myocardial infarction.

1988 • 441 citations

Synthesis of Prostacyclin from Platelet-derived Endoperoxides by Cultured Human Endothelial Cells

1980 • 385 citations

Cultured bovine endothelial cells produce both urokinase and tissue-type plasminogen activators.

1982 • 362 citations

Binding of plasminogen to cultured human endothelial cells.

1986 • 311 citations

Acute coronary reocclusion after thrombolysis with recombinant human tissue-type plasminogen activator: prevention by a maintenance infusion.

1986 • 302 citations

Immunoglobulin M antibodies present in the acute phase of Kawasaki syndrome lyse cultured vascular endothelial cells stimulated by gamma interferon.

1986 • 244 citations

Binding of tissue plasminogen activator to cultured human endothelial cells.

1987 • 223 citations

An Enzyme Linked Immunosorbent Assay for Determination of Tissue Plasminogen Activator Applied to Patients with Thromboembolic Disease

1983 • 211 citations

Pharmacokinetics and systemic fibrinogenolytic effects of recombinant human tissue-type plasminogen activator (rt-PA) in humans.

1985 • 149 citations

Plasmin inhibition of platelet function and of arachidonic acid metabolism.

1985 • 149 citations

Measurement of human tissue-type plasminogen activator by a two-site immunoradiometric assay.

1983 • 142 citations

Platelet protein phosphorylation, elevation of cytosolic calcium, and inositol phospholipid breakdown in platelet activation induced by plasmin.

1986 • 124 citations

Unidirectional transfer of prostaglandin endoperoxides between platelets and endothelial cells.

1984 • 122 citations

The Fibrinolytic System of the Vascular Wall

1985 • 119 citations

The Preparation of Human Fibrinolysin (Plasmin)

1960 • 107 citations

Isolation and characterization of a urokinase-type plasminogen activator (Mr = 54,000) from cultured human endothelial cells indistinguishable from urinary urokinase.

1984 • 77 citations

Isolation and primary culture of endothelial cells from human umbilical vessels

1978 • 74 citations

Interaction of plasmin with endothelial cells

1984 • 54 citations

Synergistic inhibition of platelet activation by plasmin and prostaglandin I2

1987 • 37 citations

Cytochalasins inhibit arachidonic acid metabolism in thrombin-stimulated platelets.

1982 • 26 citations

Inhibitory activity of antibodies to human Ia-like determinants: comparison of intact and pepsin-digested antibodies.

1983 • 21 citations

Thrombolytic agents: effects of local infusion on microvascular physiology and macrovascular ultrastructure.

1983 • 14 citations

Intracoronary Administration of Streptokinase in a Canine Model: Disturbances in Thromboxane A2-Prostacyclin Balance

1986 • 3 citations