Defect in Rearrangement of the Most 5′ TCR–Jα Following Targeted Deletion of T Early α (TEA): Implications for TCR α Locus Accessibility

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

RAG-1-deficient mice have no mature B and T lymphocytes

1992 • 2,859 citations

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

1988 • 1,690 citations

RAG-1 and RAG-2, Adjacent Genes That Synergistically Activate V(D)J Recombination

1990 • 1,450 citations

Generation and Analysis of Interleukin-4 Deficient Mice

1991 • 1,266 citations

Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1.

1988 • 1,180 citations

The V(D)J recombination activating gene, RAG-1

1989 • 1,164 citations

Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages

1992 • 1,116 citations

Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting

1993 • 984 citations

Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps

1995 • 703 citations

The Mechanism of V(D)J Joining: Lessons from Molecular, Immunological, and Comparative Analyses

1994 • 579 citations

Expression of Two T Cell Receptor α Chains: Dual Receptor T Cells

1993 • 527 citations

A new T-cell receptor gene located within the alpha locus and expressed early in T-cell differentiation

1987 • 483 citations

Introduced T cell receptor variable region gene segments recombine in pre-B cells: Evidence that B and T cells use a common recombinase

1986 • 452 citations

Development and Selection of T Cells: Facts and Puzzles

1995 • 450 citations

Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes

1993 • 403 citations

Lymphoid Development in Mice Congenitally Lacking T Cell Receptor αβ-Expressing Cells

1992 • 371 citations

Differential expression of two distinct T-cell receptors during thymocyte development

1987 • 360 citations

Targeted deletion of 5'HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus.

1995 • 351 citations

Exclusion and inclusion of α and β T cell receptor alleles

1992 • 346 citations

A dominant-negative transgene defines a role for p56lck in thymopoiesis.

1993 • 306 citations

Initiation of V(D)J recombination in a cell-free system

1995 • 286 citations

Regulation of TCR α and β gene allelic exclusion during T-cell development

1992 • 284 citations

Thymocyte Expression of RAG-1 and RAG-2: Termination by T Cell Receptor Cross-Linking

1991 • 270 citations

Multiple rearrangements in T cell receptor alpha chain genes maximize the production of useful thymocytes.

1993 • 247 citations

Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrate.

1990 • 224 citations

Genomic DNA microextraction: A method to screen numerous samples

1992 • 221 citations

V(D)J recombination in B cells is impaired but not blocked by targeted deletion of the immunoglobulin heavy chain intron enhancer.

1993 • 219 citations

Restoration of early thymocyte differentiation in T-cell receptor beta-chain-deficient mutant mice by transmembrane signaling through CD3 epsilon.

1993 • 214 citations

CD3ε-mediated signals rescue the development of CD4⁺CD8⁺ thymocytes in RAG-2^−/− mice in the absence of TCR β chain expression

1994 • 205 citations

A T cell clone expresses two T cell receptor α genes but uses one αβ heterodimer for allorecognition and self MHC-restricted antigen recognition

1988 • 200 citations

T-Cell Receptor α Locus V(D)J Recombination By-Products Are Abundant in Thymocytes and Mature T Cells

1996 • 195 citations

Derivation of a T cell hybridoma variant deprived of functional T cell receptor α and β chain transcripts reveals a nonfunctional α‐mRNA of BW5147 origin

1989 • 188 citations

Transcriptional regulation of multigene loci: multilevel control

1993 • 187 citations

B cell development in mice that lack one or both immunoglobulin kappa light chain genes.

1993 • 185 citations

T cell receptor gene recombination patterns and mechanisms: cell death, rescue, and T cell production.

1995 • 180 citations

Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development.

1996 • 179 citations

The Human T-Cell Receptor TCRAC/TCRDC (Cα/Cdelta;) Region: Organization, Sequence, and Evolution of 97.6 kb of DNA

1994 • 169 citations

Deletion of the immunoglobulin kappa chain intron enhancer abolishes kappa chain gene rearrangement in cis but not lambda chain gene rearrangement in trans.

1993 • 168 citations

A T-cell-specific transcriptional enhancer element 3' of C alpha in the human T-cell receptor alpha locus.

1989 • 165 citations

Gene-targeted deletion and replacement mutations of the T-cell receptor beta-chain enhancer: the role of enhancer elements in controlling V(D)J recombination accessibility.

1996 • 164 citations

Striking sequence similarity over almost 100 kilobases of human and mouse T–cell receptor DNA

1994 • 159 citations

CD3 components at the surface of pro‐T cells can mediate pre‐T cell development in vivo

1994 • 156 citations

A T Cell-Specific Transcriptional Enhancer within the Human T Cell Receptor δ Locus

1990 • 140 citations

α β and γ δ T cells can share a late common precursor

1995 • 139 citations

TCR beta and TCR alpha gene enhancers confer tissue- and stage-specificity on V(D)J recombination events.

1993 • 132 citations

In-frame TCR δ gene rearrangements play a critical role in the αβ/γδ T cell lineage decision

1995 • 122 citations

T cells with two functional antigen-specific receptors.

1995 • 119 citations

A locus control region in the T cell receptor α/δ locus

1994 • 109 citations

T Cell Receptor δ Gene Rearrangement and T Early α (TEA) Expression in Immature αβ LineageThymocytes: Implications for αβ/γδ Lineage Commitment

1996 • 96 citations

Human T-cell antigen receptor (TCR) delta-chain locus and elements responsible for its deletion are within the TCR alpha-chain locus.

1988 • 93 citations

An Enhancer/Locus Control Region Is Not Sufficient To Open Chromatin

1993 • 90 citations

Regulation of the β-globin locus

1993 • 88 citations

The joining of germ-line Vα to Jα genes replaces the preexisting Vα-Jα complexes in a T cell receptor α,β positive T cell line

1988 • 87 citations

Enhancer-dependent and -independent steps in the rearrangement of a human T cell receptor delta transgene.

1994 • 85 citations

Promoter, enhancer and silencer elements regulate rearrangement of an immunoglobulin transgene.

1993 • 85 citations

Differential activation of transcription versus recombination of transgenic T cell receptor beta variable region gene segments in B and T lineage cells.

1994 • 85 citations

First T cell receptor alpha gene rearrangements during T cell ontogeny skew to the 5' region of the J alpha locus.

1990 • 84 citations

Deletional rearrangement in the human T-cell receptor alpha-chain locus.

1987 • 68 citations

Rearrangement-Enhancing Element Upstream of the Mouse Immunoglobulin Kappa Chain J Cluster

1996 • 67 citations

Rearrangement of a chicken immunoglobulin gene occurs in the lymphoid lineage of transgenic mice

1987 • 64 citations

V(D)J Recombination and Double-Strand Break Repair

1995 • 60 citations

The 3′ enhancer region determines the B/T specificity and pro-B/pre-B specificity of immunoglobulin Vκ-Jκ joining

1995 • 59 citations

Rearrangement and expression of rabbit immunoglobulin kappa light chain gene in transgenic mice.

1987 • 49 citations

Regulation of transcription of the human T cell antigen receptor delta chain gene. A T lineage-specific enhancer element is located in the J delta 3-C delta intron.

1990 • 47 citations

An enhancer/locus control region is not sufficient to open chromatin.

1993 • 46 citations

Nucleotide sequence analysis of 95 kb near the 3′ end of the murine T-cell receptor αδ chain locus: Strategy and methodology

1992 • 46 citations

Functional characterization of the promoter for the human germ‐line T cell receptor J α (TEA) transcript

1993 • 44 citations

Transcription of Germ Line Vα Segments Correlates with Ongoing T-Cell Receptor α-Chain Rearrangement

1992 • 44 citations

V-D-J rearrangements at the T cell receptor σ locus in mouse thymocytes of the αβ lineage

1995 • 43 citations

Normal T cell receptor Vβ usage in a primary immunodeficiency associated with HLA class II deficiency

1993 • 40 citations

Transcription of germ line V alpha segments correlates with ongoing T-cell receptor alpha-chain rearrangement.

1992 • 35 citations

Evolutionary comparison of murine and human delta T-cell receptor deleting elements.

1989 • 33 citations

Mouse germline transcript of TCR α joining region and temporal expression in ontogeny

1993 • 26 citations

Evidence for recombinatorial hot spots at the T cell receptor Jα locus

1994 • 24 citations

Gene regulation within the TCR-α/δ locus by specific deletion of the TCR-δ cluster

1990 • 14 citations