Determinants and Mechanisms of Human Immune Responses to Bee Venom Phospholipase A<sub>2</sub>

Lymphokine Control of In Vivo Immunoglobulin Isotype Selection

1990 • 1,303 citations

Role of interleukin 10 in specific immunotherapy.

1998 • 980 citations

LIGAND RECOGNITION BY αβ T CELL RECEPTORS

1998 • 904 citations

Serologic aspects of IgG4 antibodies. I. Prolonged immunization results in an IgG4-restricted response.

1983 • 727 citations

Successful immunotherapy with T-cell epitope peptides of bee venom phospholipase A2 induces specific T-cell anergy in patients allergic to bee venom☆☆☆★★★

1998 • 458 citations

Crystal Structure of Bee-Venom Phospholipase A ₂ in a Complex with a Transition-State Analogue

1990 • 442 citations

Murine Th1 and Th2 clones proliferate optimally in response to distinct antigen-presenting cell populations.

1991 • 355 citations

Epitope-specific T cell tolerance to phospholipase A2 in bee venom immunotherapy and recovery by IL-2 and IL-15 in vitro.

1996 • 312 citations

Modulation of IgE reactivity of allergens by site‐directed mutagenesis: potential use of hypoallergenic variants for immunotherapy

1998 • 271 citations

How some T cells escape tolerance induction

1989 • 216 citations

Fucose α1,3-Linked to the Core Region of Glycoprotein N-Glycans Creates an Important Epitope for IgE from Honeybee Venom Allergic Individuals

1993 • 216 citations

How the MHC selects Th1/Th2 immunity

1998 • 178 citations

Infection breaks T-cell tolerance

1992 • 174 citations

Analysis of the cDNA for phospholipase A₂ from honeybee venom glands

1989 • 153 citations

T cell epitope specificity in human allergic and nonallergic subjects to bee venom phospholipase A2.

1993 • 153 citations

Interleukin-2 can prevent and reverse antigen-induced unresponsiveness in cloned human T lymphocytes.

1988 • 146 citations

MHC class II function preserved by low-affinity peptide interactions preceding stable binding

1994 • 135 citations

Bee venom phospholipase A2‐specific T cell clones from human allergic and non‐allergic individuals: cytokine patterns change in response to the antigen concentration

1992 • 114 citations

Differential regulation of human T cell cytokine patterns and IgE and IgG4 responses by conformational antigen variants

1998 • 98 citations

Lymphokine Control Of In Vivo Immunoglobulin Isotype Selection

1990 • 87 citations

Type I skin reactivity to native and recombinant phospholipase A from honeybee venom is similar

1995 • 87 citations

Carbohydrate‐dependent, HLA class II‐restricted, human T cell response to the bee venom allergen phospholipase A2 in allergic patients

1995 • 73 citations

Regulation of the immune response to peptide antigens: differential induction of immediate-type hypersensitivity and T cell proliferation due to changes in either peptide structure or major histocompatibility complex haplotype.

1991 • 72 citations

Induction and differential regulation of bee venom phospholipase A2–specific human IgE and IgG4 antibodies in vitro requires allergen-specific and nonspecific activation of T and B cells☆, ☆☆, ★, ★★

1997 • 67 citations

The intensity of T cell receptor engagement determines the cytokine pattern of human allergen‐specific T helper cells

1997 • 61 citations

Regulation of IgE and IgG responses by allergen specific T-cell clones to bee venom phospholipase A in vitro

1994 • 61 citations

Theoretical and Practical Aspects of B‐Cell Activation: Murine and Human Systems

1987 • 58 citations

Defective TCR stimulation in anergized type 2 T helper cells correlates with abrogated p56(lck) and ZAP-70 tyrosine kinase activities.

1997 • 55 citations

Mapping human T cell epitopes on phospholipase A2: The major bee-venom allergen+

1992 • 54 citations

Increased specificity of diagnostic tests with recombinant major bee venom allergen phospholipase A2

1997 • 49 citations

An Altered Peptide Ligand Specifically Inhibits Th2 Cytokine Synthesis by Abrogating TCR Signaling

1999 • 44 citations

Allergen Dose Dependent Cytokine Production Regulates Specific Ige And Igg Antibody Production

1996 • 37 citations

Interleukin‐4 induces both lgg4 and ige secretion by peripheral blood b cells

1990 • 36 citations

Isotypic and Idiotypic Characterization of Anti-Bee Venom Phospholipase A<sub>2</sub> Antibodies

1985 • 35 citations

Human monoclonal or polyclonal antibodies recognize predominantly discontinuous epitopes on bee venom phospholipase A2

1994 • 33 citations

Delineation of PLA₂epitopes using short or long overlapping synthetic peptides: interest for specific immunotherapy

1997 • 33 citations

Antigenic surface of the bee venom allergen phospholipase A2. Structural functional analysis of human IgG4 antibodies reveals potential role in protection.

1994 • 26 citations

Enzymatic activity of soluble phospholipase A₂ does not affect the specific IgE, IgG4 and cytokine responses in bee sting allergy

1998 • 16 citations

Regulation of the Cytokine Production of Allergen-Specific Human T-Cell Clones by the Allergen

1992 • 8 citations

Lysine Residues in Bee Venom Phospholipase A<sub>2</sub> Are Important for Binding to Human Monoclonal or Polyclonal Antibodies of the lgG4 Isotope

1994 • 7 citations