Regulation of the immune response to peptide antigens: differential induction of immediate-type hypersensitivity and T cell proliferation due to changes in either peptide structure or major histocompatibility complex haplotype.

Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule.

1983 • 1,307 citations

Two types of murine helper T cell clone. II. Delayed-type hypersensitivity is mediated by TH1 clones.

1987 • 966 citations

T-Lymphocyte Recognition of Antigen in Association with Gene Products of the Major Histocompatibility Complex

1985 • 942 citations

B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells.

1986 • 797 citations

The Role of Helper T Cell Products in Mouse B Cell Differentiation and Isotype Regulation

1988 • 764 citations

Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1

1985 • 749 citations

Antigen recognition by H-2-restricted T cells. I. Cell-free antigen processing.

1983 • 701 citations

The Relation Between Major Histocompatibility Complex (MHC) Restriction and the Capacity of Ia to Bind Immunogenic Peptides

1987 • 696 citations

T cell-derived B cell differentiation factor(s). Effect on the isotype switch of murine B cells.

1982 • 445 citations

Serological, biochemical, and functional identity of B cell-stimulatory factor 1 and B cell differentiation factor for IgG1.

1985 • 410 citations

Effect of Combinations of Inbred Strain, Antigen, and Antigen Dose on Immune Responsiveness and Reagin Production in the Mouse

1970 • 372 citations

Structural characteristics of an antigen required for its interaction with Ia and recognition by T cells

1987 • 367 citations

Suppression of in vivo polyclonal IgE responses by monoclonal antibody to the lymphokine B-cell stimulatory factor 1.

1986 • 355 citations

Interactions between Immunogenic Peptides and MHC Proteins

1991 • 303 citations

Identification of the T-cell and Ia contact residues of a T-cell antigenic epitope

1987 • 297 citations

Derivation of a T cell line that is highly responsive to IL-4 and IL-2 (CT.4R) and of an IL-2 hyporesponsive mutant of that line (CT.4S).

1989 • 289 citations

H-2 haplotypes, genes, and antigens: Second listing

1982 • 283 citations

CD4+ T Cells: Specificity and Function

1988 • 281 citations

Cholera toxin discriminates between T helper 1 and 2 cells in T cell receptor-mediated activation: role of cAMP in T cell proliferation.

1990 • 238 citations

The binary logic of antigen processing and presentation to T cells

1990 • 235 citations

Priming for and induction of anti-poliovirus neutralizing antibodies by synthetic peptides

1983 • 234 citations

Interaction of peptide antigens and class II major histocompatibility complex antigens

1986 • 221 citations

Evidence implicating utilization of different T cell receptor-associated signaling pathways by TH1 and TH2 clones.

1990 • 218 citations

Non-responsiveness to a foot-and-mouth disease virus peptide overcome by addition of foreign helper T-cell determinants

1987 • 216 citations

Cloned, Ia-restricted T cells that do not produce interleukin 4(IL 4)/B cell stimulatory factor 1(BSF-1) fail to help antigen-specific B cells.

1987 • 209 citations

Cellular Events in the IgE Antibody Response

1976 • 205 citations

Heterogeneity of helper/inducer T lymphocytes. II. Effects of interleukin 4- and interleukin 2-producing T cell clones on resting B lymphocytes.

1988 • 198 citations

Autocrine growth of CD4+ T cells. Differential effects of IL-1 on helper and inflammatory T cells.

1988 • 183 citations

Characterization of T helper 1 and 2 cell subsets in normal mice. Helper T cells responsible for IL-4 and IL-5 production are present as precursors that require priming before they develop into lymphokine-secreting cells.

1988 • 172 citations

Frequencies of IL-2- and IL-4-secreting T cells in naive and antigen-stimulated lymphocyte populations.

1988 • 164 citations

Protein Antigenic Structures Recognized by T Cells; Potential Applications to Vaccine Design

1987 • 139 citations

Antigen and antibody detection by in vivo methods; A reevaluation of passive cutaneous anaphylactic reactions

1977 • 139 citations

Protein-antigen specific Ia-restricted cytolytic T cells: analysis of frequency, target cell susceptibility, and mechanism of cytolysis.

1985 • 122 citations

MHC control of CD4+ T cell subset activation.

1989 • 121 citations

Recent studies on the regulation of IgE antibody synthesis in experimental animals and man.

1980 • 120 citations

Anti-CD3 antibody induces unresponsiveness to IL-2 in Th1 clones but not in Th2 clones.

1990 • 109 citations

Th1 and Th2 clones differ in their response to a tolerogenic signal.

1990 • 102 citations

Murine CD4+ T cell subsets defined.

1988 • 102 citations

HAPTEN-SPECIFIC IgE ANTIBODY RESPONSES IN MICE

1973 • 100 citations

Synthetic peptides: a next generation of vaccines?

1987 • 100 citations

Experimental Allergic Encephalomyelitis ‐ Susceptibility and Suppression

1981 • 88 citations

Murine MHC Polymorphism and T Cell Specificities

1989 • 82 citations

T lymphocyte response to bacteriophage lambda repressor cI protein. Recognition of the same peptide presented by Ia molecules of different haplotypes.

1987 • 68 citations

Evidence that Mls-2 antigens which delete V beta 3+ T cells are controlled by multiple genes.

1989 • 62 citations

Differential activation of cytokine genes in normal CD4‐bearing T cells is stimulus dependent

1989 • 60 citations

Analysis of peptide binding patterns in different major histocompatibility complex/T cell receptor complexes using pigeon cytochrome c-specific T cell hybridomas. Evidence that a single peptide binds major histocompatibility complex in different conformations.

1989 • 56 citations

Immune response gene control of determinant selection. III. Polypeptide fragments of insulin are differentially recognized by T but not by B cells in insulin immune guinea pigs.

1981 • 53 citations

Repertoires of T cells directed against a large protein antigen, beta-galactosidase. I. Helper cells have a more restricted specificity repertoire than proliferative cells.

1982 • 53 citations

Inverse Ir gene control of the antibody and T cell proliferative responses to human basement membrane collagen.

1987 • 46 citations

Hapten-specific IgE antibody responses in mice. 3. Establishment of parameters for generation of helper T cell function regulating the primary and secondary responses of IgE and IgG B lymphocytes.

1974 • 43 citations

The activation of pigeon cytochrome c-specific T cell hybridomas by antigenic peptides is influenced by non-native sequences at the amino terminus of the determinant.

1988 • 41 citations

The Measurement of Serum Immunoglobulin E Levels in Healthy Adults and Children and in Children with Allergic Asthma

1970 • 38 citations

T-Lymphocyte Recognition of Antigen in Association with Gene Products of the Major Histocompatibility Complex

1985 • 37 citations

Mast Cell Activation and Mediator Release

1984 • 37 citations

Specificity of the T Cell Receptor for Antigen

1988 • 34 citations

Minimum peptide sequences necessary for priming and triggering of humoral and cell-mediated immune responses in mice: use of synthetic peptide antigens of defined structure.

1980 • 32 citations

Differential induction of interferon gamma gene expression after activation of CD4+ T cells by conventional antigen and Mls superantigen.

1991 • 30 citations

Enhanced immunogenicity of a T cell immunogenic peptide by modifications of its N and C termini

1989 • 29 citations

Amino acid variations at a single residue in an autoimmune peptide profoundly affect its properties: T-cell activation, major histocompatibility complex binding, and ability to block experimental allergic encephalomyelitis.

1991 • 29 citations

Proliferating and helper T lymphocytes display distinct fine specificities in response to human fibrinopeptide B.

1983 • 20 citations

Influence of the macromolecular form of a B cell epitope on the expression of antibody variable and constant region structure.

1987 • 19 citations

Requirements for the growth of T_H1 lymphocyte clones

1990 • 17 citations

The AKR thymoma BW5147 is able to produce lymphokines when stimulated with calcium ionophore and phorbol ester.

1988 • 15 citations

Immunization and Fusion Protocols for Hybridoma Production

2003 • 7 citations

Intra-H-2 recombination inH-2b/H-2t1 heterozygotes in the mouse

1978 • 3 citations

Amino acid variations at a single residue in an autoimmune peptide profoundly affect its properties: T-cell activation, major histocompatibility complex binding, and ability to block experimental allergic encephalomyelitis.

1991 • 3 citations

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