Chronic effects of γ-interferon on quinolinic acid and indoleamine-2,3-dioxygenase in brain of C57BL6 mice

Quinolinic Acid: An Endogenous Metabolite That Produces Axon-Sparing Lesions in Rat Brain

1983 • 1,247 citations

EXACERBATIONS OF MULTIPLE SCLEROSIS IN PATIENTS TREATED WITH GAMMA INTERFERON

1987 • 1,062 citations

Quinolinic acid in cerebrospinal fluid and serum in HIV‐1 Infection: Relationship to clinical and neurological status

1991 • 563 citations

Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acid

1984 • 416 citations

Tryptophan degradation in mice initiated by indoleamine 2,3-dioxygenase.

1986 • 372 citations

Biochemistry of tryptophan in health and disease

1983 • 329 citations

Kynurenic acid inhibits synaptic and acidic amino acid-induced responses in the rat hippocampus and spinal cord

1983 • 307 citations

l-Kynurenine Its synthesis and possible regulatory function in brain

1980 • 299 citations

Human indolylamine 2,3-dioxygenase. Its tissue distribution, and characterization of the placental enzyme

1985 • 237 citations

Rat Brain Slices Produce and Liberate Kynurenic Acid upon Exposure to <scp>l</scp>‐Kynurenine

1989 • 221 citations

Pharmacology and regional variations of quinolinic acid-evoked excitations in the rat central nervous system.

1983 • 209 citations

Stimulant and convulsive effects of kynurenines injected into brain ventricles in mice

1978 • 181 citations

Prolonged exposure to submicromolar concentrations of quinolinic acid causes excitotoxic damage in organotypic cultures of rat corticostriatal system

1989 • 175 citations

Interferon-Induced Indoleamine 2,3-Dioxygenase Activity InhibitsChlamydia psittaciReplication in Human Macrophages

1989 • 136 citations

Quantification of quinolinic acid in rat brain, whole blood, and plasma by gas chromatography and negative chemical ionization mass spectrometry: Effects of systemic l-tryptophan administration on brain and blood quinolinic acid concentrations

1988 • 126 citations

Studies on the disposition of quinolinic acid after intracerebral or systemic administration in the rat

1984 • 115 citations

Determination of serum kynurenine and hepatic tryptophan dioxygenase activity by high-performance liquid chromatography

1988 • 111 citations

Inhibition of tumor cell growth by interferon-gamma is mediated by two distinct mechanisms dependent upon oxygen tension: induction of tryptophan degradation and depletion of intracellular nicotinamide adenine dinucleotide.

1989 • 107 citations

Increased Cerebrospinal Fluid Quinolinic Acid, Kynurenic Acid, and L‐Kynurenine in Acute Septicemia

1990 • 80 citations

Systemic endotoxin increasesl-tryptophan, 5-hydroxyindoleacetic acid, 3-hydroxykynurenine and quinolinic acid content of mouse cerebral cortex

1989 • 76 citations

Increased ratio of quinolinic acid to kynurenic acid in cerebrospinal fluid of D retrovirus—infected rhesus macaques: Relationship to clinical and viral status

1990 • 73 citations

Quinolinic Acid Concentrations in Brain and Cerebrospinal Fluid of Patients with Intractable Complex Partial Seizures

1990 • 58 citations

[50] l-tryptophan 2,3-dioxygenase (tryptophan pyrrolase) (rat liver)

1970 • 55 citations

Quantification of kynurenic acid in cerebrospinal fluid: effects of systemic and central l-kynurenine administration

1990 • 54 citations

Interferon: A mediator of indoleamine 2,3-dioxygenase induction by lipopolysaccharide, poly(I) · poly(C), and pokeweed mitogen in mouse lung

1986 • 50 citations

Cerebral cortex and lung indoleamine-2,3-dioxygenase activity is increased in type-D retrovirus infected macaques

1991 • 49 citations

(18O)quinolinic acid: Its esterification without back exchange for use as internal standard in the quantification of brain and CSF quinolinic acid

1988 • 47 citations

A phase I trial of recombinant human interferon-γ in patients with Kaposi's sarcoma and the acquired immunodeficiency syndrome (AIDS)

1989 • 37 citations

Use of IFN-gamma in patients with AIDS.

1990 • 32 citations

Sustained increases in cerebrospinal fluid quinolinic acid concentrations in rhesus macaques (Macaca mulatta) naturally infected with simian retrovirus type-D

1990 • 32 citations

Neurophysiological effects of recombinant interferon-gamma and -alpha in man.

1989 • 29 citations

Interferons and antiviral activity.

1986 • 18 citations

Recombinant interferon-γ applied to the brain ventricular system protects rats against pseudorabies

1990 • 11 citations