Fas Antigen and Sphingomyelin‐Ceramide Turnover‐Mediated Signaling: Role in Life and Death of T Lymphocytes¹

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1991 • 2,815 citations

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

Recombinant Human Tumor Necrosis Factor-α: Effects on Proliferation of Normal and Transformed Cells in Vitro

1985 • 1,596 citations

A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor.

1989 • 1,436 citations

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

1991 • 1,223 citations

Lpr and gld: Single Gene Models of Systemic Autoimmunity and Lymphoproliferative Disease

1991 • 1,185 citations

Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB

1993 • 1,129 citations

TNF activates NF-κB by phosphatidylcholine-specific phospholipase C-induced “Acidic” sphingomyelin breakdown

1992 • 1,058 citations

Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation.

1993 • 1,047 citations

lnterleukin-2 programs mouse αβ T lymphocytes for apoptosis

1991 • 1,027 citations

Regulation of Lymphokine Messenger RNA Stability by a Surface-Mediated T Cell Activation Pathway

1989 • 910 citations

Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity

1990 • 904 citations

T-cell receptor Vβ use predicts reactivity and tolerance to Mlsa- encoded antigens

1988 • 901 citations

The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen.

1992 • 839 citations

Programmed cell death and extrathymic reduction of Vβ8+CD4+ T cells in mice tolerant to Staphylococcus aureus enterotoxin B

1991 • 675 citations

Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation.

1991 • 621 citations

Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase.

1994 • 582 citations

Thymus cell migration: Quantitative aspects of cellular traffic from the thymus to the periphery in mice

1980 • 551 citations

Fas transduces activation signals in normal human T lymphocytes.

1993 • 521 citations

Purification and characterization of the Fas-ligand that induces apoptosis.

1994 • 521 citations

Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice.

1993 • 510 citations

Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation.

1990 • 476 citations

Activation of the Sphingomyelin Signaling Pathway in Intact EL4 Cells and in a Cell-Free System By IL-1β

1993 • 433 citations

Tumor Necrosis Factor-α Activates the Sphingomyelin Signal Transduction Pathway in a Cell-Free System

1992 • 428 citations

Ceramide stimulates a cytosolic protein phosphatase.

1992 • 406 citations

DNA fragmentation and cell death is selectively triggered in activated human lymphocytes by Fas antigen engagement

1992 • 392 citations

Interleukin 4 protects chronic lymphocytic leukemic B cells from death by apoptosis and upregulates Bcl-2 expression.

1992 • 366 citations

c-myc gene is transcribed at high rate in G0-arrested fibroblasts and is post-transcriptionally regulated in response to growth factors

1985 • 300 citations

Autoimmune disease in mice due to integration of an endogenous retrovirus in an apoptosis gene.

1993 • 287 citations

Expression of the Bcl-2 protein in murine and human thymocytes and in peripheral T lymphocytes.

1993 • 286 citations

Sphingomyelinase and ceramide activate mitogen-activated protein kinase in myeloid HL-60 cells

1993 • 262 citations

Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28.

1994 • 257 citations

Propriocidal apoptosis of mature T lymphocytes occurs at S phase of the cell cycle

1993 • 252 citations

The defect in Fas mRNA expression in MRL/lpr mice is associated with insertion of the retrotransposon, ETn.

1993 • 241 citations

Programmed death of autoreactive thymocytes

1990 • 224 citations

The progressive differentiation of primed T cells is associated with an increasing susceptibility to apoptosis

1994 • 210 citations

Activation-driven T cell death. I. Requirements for de novo transcription and translation and association with genome fragmentation.

1989 • 194 citations

Encyclopedia of immunology

1992 • 183 citations

APO‐1 mediated apoptosis or proliferation in human chronic B lymphocytic leukemia: Correlation with bcl‐2 oncogene expression

1993 • 178 citations

Fas‐based lymphocyte‐mediated cytotoxicity against syngeneic activated lymphocytes: A regulatory pathway?

1994 • 157 citations

Selection of the T cell receptor repertoire in Lpr mice.

1993 • 155 citations

Correction of accelerated autoimmune disease by early replacement of the mutated lpr gene with the normal Fas apoptosis gene in the T cells of transgenic MRL-lpr/lpr mice.

1994 • 145 citations

MINIREVIEW: Insights into Hormonal Control of Messenger RNA Stability

1990 • 144 citations

gld/gld mice are unable to express a functional ligand for Fas

1994 • 140 citations

AIDS pathogenesis: a dynamic interaction between HIV and the immune system

1990 • 129 citations

Activation-driven T cell death. II. Quantitative differences alone distinguish stimuli triggering nontransformed T cell proliferation or death.

1992 • 120 citations

Defective thymic T cell activation by concanavalin A and anti-CD3 in autoimmune nonobese diabetic mice. Evidence for thymic T cell anergy that correlates with the onset of insulitis.

1991 • 101 citations

T cell receptor-mediated DNA fragmentation and cell death in T cell hybridomas.

1990 • 98 citations

Origin of CD4-CD8-B220+ T cells in MRL-lpr/lpr mice. Clues from a T cell receptor beta transgenic mouse.

1993 • 98 citations

Mechanism of Phosphorylation of the Epidermal Growth Factor Receptor at Threonine 669

1989 • 93 citations

Correlation between the anticellular and DNA fragmenting activities of tumor necrosis factor.

1988 • 78 citations

Tumor necrosis factor inhibits MYC expression in HL-60 cells at the level of mRNA transcription.

1987 • 77 citations

Evidence that interleukin-1 and phorbol esters activate NF-kappa B by different pathways: role of protein kinase C.

1991 • 68 citations

Coming to terms with death: apoptosis in cancer and immune development

1994 • 56 citations

Correction of gld autoimmunity by co-infusion of normal bone marrow suggests that gld is a mutation of the Fas ligand gene

1993 • 46 citations

Autoreactive T cells in MRL/Mpr-lpr/lpr mice. Characterization of the lymphokines produced and analysis of antigen-presenting cells required.

1988 • 43 citations

Functional distinctions between MRL-lpr and MRL-gld lymphocytes. Normal cells reverse the gld but not lpr immunoregulatory defect.

1994 • 28 citations

Murine models of autoimmune disease and Sjögrenʼs syndrome

1993 • 17 citations

High Concentrations of Estrogen Stabilize Vitellogenin mRNA against Cytoplasmic Degradation but Physiological Concentrations do not

1990 • 15 citations