CHASING THE CANCER DEMON

Mutation and Cancer: Statistical Study of Retinoblastoma

1971 • 7,335 citations

Cancer Cell Cycles

1996 • 5,379 citations

A New Consistent Chromosomal Abnormality in Chronic Myelogenous Leukaemia identified by Quinacrine Fluorescence and Giemsa Staining

1973 • 4,217 citations

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

1990 • 3,720 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

1986 • 2,968 citations

Identification of the von Hippel-Lindau Disease Tumor Suppressor Gene

1993 • 2,906 citations

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

1993 • 2,884 citations

Identification and characterization of the familial adenomatous polyposis coli gene

1991 • 2,806 citations

Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

1993 • 2,711 citations

T antigen is bound to a host protein in SY40-transformed cells

1979 • 2,378 citations

A minute chromosome in human chronic granulocytic leukemia

1960 • 2,329 citations

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

1993 • 2,282 citations

Mutation in the DNA mismatch repair gene homologue hMLH 1 is associated with hereditary non-polyposis colon cancer

1994 • 2,071 citations

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

1997 • 2,063 citations

Viral RNA-dependent DNA Polymerase: RNA-dependent DNA Polymerase in Virions of Rous Sarcoma Virus

1970 • 2,061 citations

Mutations of the Human Homolog of Drosophila patched in the Nevoid Basal Cell Carcinoma Syndrome

1996 • 2,021 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

Viral RNA-dependent DNA Polymerase: RNA-dependent DNA Polymerase in Virions of RNA Tumour Viruses

1970 • 1,992 citations

Expression of recessive alleles by chromosomal mechanisms in retinoblastoma

1983 • 1,952 citations

Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A

1993 • 1,941 citations

Mutations of Chromosome 5q21 Genes in FAP and Colorectal Cancer Patients

1991 • 1,890 citations

Human Homolog of patched , a Candidate Gene for the Basal Cell Nevus Syndrome

1996 • 1,850 citations

Mutation of a mutL Homolog in Hereditary Colon Cancer

1994 • 1,834 citations

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

1979 • 1,830 citations

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

1990 • 1,796 citations

Comparative Genomics of the Eukaryotes

2000 • 1,688 citations

Identification and characterization of the tuberous sclerosis gene on chromosome 16

1993 • 1,617 citations

Identification of the Tuberous Sclerosis Gene TSC1 on Chromosome 9q34

1997 • 1,613 citations

A serine/threonine kinase gene defective in Peutz–Jeghers syndrome

1998 • 1,588 citations

Multiple Intestinal Neoplasia Caused by a Mutation in the Murine Homolog of the APC Gene

1992 • 1,510 citations

Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas

1997 • 1,508 citations

SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene

1988 • 1,490 citations

Type 1 Neurofibromatosis Gene: Identification of a Large Transcript Disrupted in Three NF1 Patients

1990 • 1,471 citations

The E2F transcription factor is a cellular target for the RB protein

1991 • 1,461 citations

Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

1988 • 1,440 citations

Soft-Tissue Sarcomas, Breast Cancer, and Other Neoplasms

1969 • 1,437 citations

A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor

1993 • 1,376 citations

Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2

1993 • 1,360 citations

Linkage of ATM to Cell Cycle Regulation by the Chk2 Protein Kinase

1998 • 1,314 citations

DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA

1976 • 1,290 citations

Mutations in the RET proto-oncogene are associated with MEN 2A and FMTC

1993 • 1,273 citations

Oncogenic Transcription Factors in the Human Acute Leukemias

1997 • 1,227 citations

Peutz-Jeghers syndrome is caused by mutations in a novel serine threoninekinase

1998 • 1,176 citations

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles

1992 • 1,117 citations

A major segment of the neurofibromatosis type 1 gene: cDNA sequence, genomic structure, and point mutations

1990 • 1,107 citations

Deletions and a translocation interrupt a cloned gene at the neurofibromatosis type 1 locus

1990 • 1,085 citations

Heterozygous Germ Line hCHK2 Mutations in Li-Fraumeni Syndrome

1999 • 908 citations

Mutations in the SMAD4/DPC4 Gene in Juvenile Polyposis

1998 • 901 citations

Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties

1992 • 846 citations

Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma

1996 • 806 citations

Abnormal Centrosome Amplification in the Absence of p53

1996 • 802 citations

p53 functions as a cell cycle control protein in osteosarcomas.

1990 • 774 citations

A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F

1992 • 652 citations

The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner

1992 • 588 citations

Second primary neoplasms in patients with retinoblastoma

1986 • 563 citations

DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation

2000 • 546 citations

Rearrangement of the p53 gene in human osteogenic sarcomas.

1987 • 489 citations

The mutation rate and cancer

1996 • 459 citations

A General Theory of Carcinogenesis

1973 • 456 citations

The retinoblastoma protein copurifies with E2F-I, an E1A-regulated inhibitor of the transcription factor E2F

1991 • 446 citations

Mutator phenotypes in human colorectal carcinoma cell lines.

1994 • 428 citations

Chromosomal breakage-fusion-bridge events cause genetic intratumor heterogeneity

2000 • 425 citations

THE CRITICAL ROLE OF CHROMOSOME TRANSLOCATIONS IN HUMAN LEUKEMIAS

1998 • 407 citations

Rhabdomyosarcoma in Children: Epidemiologic Study and Identification of a Familial Caneer Syndrome

1969 • 398 citations

The onset and extent of genomic instability in sporadic colorectal tumor progression

1999 • 388 citations

Inactivation of ataxia telangiectasia mutated gene in B-cell chronic lymphocytic leukaemia

1999 • 371 citations

Molecular Basis of Human B Cell Neoplasia

1985 • 316 citations

Predisposition to renal carcinoma in the Eker rat is determined by germ-line mutation of the tuberous sclerosis 2 (TSC2) gene.

1994 • 305 citations

A germline insertion in the tuberous sclerosis (Tsc2) gene gives rise to the Eker rat model of dominantly inherited cancer

1995 • 301 citations

Chromosomal Deletion and Retinoblastoma

1976 • 283 citations

Centrosome amplification and instability occurs exclusively in aneuploid, but not in diploid colorectal cancer cell lines, and correlates with numerical chromosomal aberrations

2000 • 274 citations

Chromosomal instability and cytoskeletal defects in oral cancer cells

2000 • 269 citations

Molecular basis of human B cell neoplasia

1985 • 244 citations

Cancer Cells Exhibit a Mutator Phenotype

1997 • 243 citations

Mutation and Human Cancer

1973 • 210 citations

Growth- and differentiation-associated expression of bcl-2 in B-chronic lymphocytic leukemia cells

1992 • 206 citations

Chromosomal reorganization for the expression of recessive mutation of retinoblastoma susceptibility gene in the development of osteosarcoma.

1988 • 204 citations

Retinoblastoma: a prototypic hereditary neoplasm.

1978 • 197 citations

A Dominant Gene for Renal Adenomas in the Rat

1961 • 155 citations

Mutations in DPC4 (SMAD4) cause juvenile polyposis syndrome, but only account for a minority of cases

1998 • 144 citations

Model for the incidence of embryonal cancers: application to retinoblastoma.

1978 • 134 citations

The cytogenetics of ataxia telangiectasia

1991 • 125 citations

Chromosome 13 homozygosity in osteosarcoma without retinoblastoma.

1986 • 106 citations

The Natural Somatic Mutation Frequency and Human Carcinogenesis

1997 • 103 citations

Differential requirement for p19ARF in the p53-dependent arrest induced by DNA damage, microtubule disruption, and ribonucleotide depletion

2000 • 103 citations

Loss of function of the tuberous sclerosis 2 tumor suppressor gene results in embryonic lethality characterized by disrupted neuroepithelial growth and development

1998 • 102 citations

Hereditary renal adenomas and adenocarcinomas in rats.

1981 • 101 citations

Mouse models in tumor suppression

1998 • 97 citations

Sporadic bilateral retinoblastoma and 13q‐chromosomal deletion

1976 • 95 citations

Complex karyotypes in a series of pediatric osteosarcomas

1989 • 69 citations

Assignment of common allele loss in osteosarcoma to the subregion 17p13.

1989 • 65 citations

Stem cell regulation, tissue ontogeny, and oncogenic events.

1992 • 38 citations

National Cancer Institute Workshop Report: The Phakomatoses Revisited

2000 • 18 citations

Transient Inhibition of Avian Myeloblastosis Virus Reproduction by Amethopterin and Fluorodeoxyuridine

1967 • 17 citations

Ethnic differences in childhood leukemia as revealed by a study of antecedent variables

1965 • 12 citations

Congenital Viral Infection and Human Disease

1966 • 4 citations