Viruses, host responses, and autoimmunity

Counting Antigen-Specific CD8 T Cells: A Reevaluation of Bystander Activation during Viral Infection

1998 • 1,996 citations

Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein

1995 • 1,528 citations

Potent and Selective Stimulation of Memory-Phenotype CD8+ T Cells In Vivo by IL-15

1998 • 1,262 citations

Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice

1991 • 1,187 citations

Activated microglia mediate neuronal cell injury via a nitric oxide mechanism.

1992 • 1,121 citations

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes

1993 • 1,087 citations

Induction of Bystander T Cell Proliferation by Viruses and Type I Interferon in Vivo

1996 • 1,077 citations

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice

1993 • 962 citations

Molecular mimicry and autoimmune disease

1987 • 943 citations

Amino Acid Homology Between the Encephalitogenic Site of Myelin Basic Protein and Virus: Mechanism for Autoimmunity

1985 • 941 citations

Massive Expansion of Antigen-Specific CD8+ T Cells during an Acute Virus Infection

1998 • 794 citations

Heme oxygenase: A novel target for the modulation of inflammatory response

1996 • 784 citations

Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: Role of anti-self (virus) immune response

1991 • 766 citations

Inducers of interferon and host resistance. II. Multistranded synthetic polynucleotide complexes.

1967 • 699 citations

Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity

1993 • 688 citations

Diabetes induced by Coxsackie virus: Initiation by bystander damage and not molecular mimicry

1998 • 669 citations

Molecular mimicry and immune‐mediated diseases

1998 • 592 citations

Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading

1997 • 558 citations

Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis.

1995 • 522 citations

Molecular Mimicry by Herpes Simplex Virus-Type 1: Autoimmune Disease After Viral Infection

1998 • 505 citations

Autoimmunity to two forms of glutamate decarboxylase in insulin-dependent diabetes mellitus.

1992 • 494 citations

Interleukin 10, a novel B cell stimulatory factor: unresponsiveness of X chromosome-linked immunodeficiency B cells.

1990 • 487 citations

Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-gamma

1988 • 476 citations

Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes.

1994 • 452 citations

A molecular model of MHC class-I-restricted antigen processing

1992 • 438 citations

Virus-induced diabetes mellitus

1977 • 433 citations

A Prospective Study of the Role of Coxsackie B and Other Enterovirus Infections in the Pathogenesis of IDDM

1995 • 423 citations

Viral Antibodies in Diabetes Mellitus

1969 • 413 citations

Loss of pancreatic islet tolerance induced by β-cell expression of interferon-γ

1990 • 343 citations

Cross-reactivities in memory cytotoxic T lymphocyte recognition of heterologous viruses.

1994 • 317 citations

Pancreatic expression of interleukin-4 abrogates insulitis and autoimmune diabetes in nonobese diabetic (NOD) mice.

1996 • 311 citations

How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model

1994 • 309 citations

HLA DRB4 0101-restricted immunodominant T cell autoepitope of pyruvate dehydrogenase complex in primary biliary cirrhosis: evidence of molecular mimicry in human autoimmune diseases.

1995 • 301 citations

Production of interleukin 10 by islet cells accelerates immune-mediated destruction of beta cells in nonobese diabetic mice.

1994 • 300 citations

Polygenic control of autoimmune diabetes in nonobese diabetic mice

1993 • 298 citations

Regulatory T Cells in the Control of Autoimmunity: the Essential Role of Transforming Growth Factor β and Interleukin 4 in the Prevention of Autoimmune Thyroiditis in Rats by Peripheral CD4+CD45RC− Cells and CD4+CD8− Thymocytes

1999 • 269 citations

Viral infections trigger multiple sclerosis relapses: a prospective seroepidemiological study

1993 • 264 citations

Detection of GAD65 Antibodies in Diabetes and Other Autoimmune Diseases Using a Simple Radioligand Assay

1994 • 261 citations

Astrocyte-specific but not neuron-specific transmembrane TNF triggers inflammation and degeneration in the central nervous system of transgenic mice.

1997 • 255 citations

Molecular mimicry: frequency of reactivity of monoclonal antiviral antibodies with normal tissues

1986 • 243 citations

Sequence Homology Between Certain Viral Proteins and Proteins Related to Encephalomyelitis and Neuritis

1985 • 243 citations

Epidemiologic contributions to multiple sclerosis

1980 • 236 citations

Geographic Differences in the Risk of Insulin-dependent Diabetes Mellitus: The Importance of Registries

1985 • 211 citations

Coxsackie Viruses and Diabetes Mellitus

1973 • 205 citations

The basis of autoimmunity: part II genetic predisposition

1995 • 205 citations

Differential Expression of Inflammatory Cytokines Parallels Progression of Central Nervous System Pathology in Two Clinically Distinct Models of Multiple Sclerosis

1998 • 200 citations

Absence of neurological deficits following extensive demyelination in a class I-deficient murine model of multiple sclerosis

1998 • 198 citations

Local Expression of TNFα in Neonatal NOD Mice Promotes Diabetes by Enhancing Presentation of Islet Antigens

1998 • 195 citations

Frequent expression of interleukin-10 by Epstein-Barr virus-harboring tumor cells of Hodgkin's disease

1996 • 193 citations

TGF-β1 Alters APC Preference, Polarizing Islet Antigen Responses toward a Th2 Phenotype

1998 • 180 citations

Primary demyelination in transgenic mice expressing interferon-γ

1997 • 180 citations

Cytokine Release from Microglia: Differential Inhibition by Pentoxifylline and Dexamethasone

1992 • 179 citations

Bystander Activation of Cytotoxic T Cells: Studies on the Mechanism and Evaluation of In Vivo Significance in a Transgenic Mouse Model

1997 • 176 citations

Experimental models of virus‐induced demyelination of the central nervous system

1982 • 174 citations

Detection of Coxsackie B Virus RNA sequences in whole blood samples from adult patients at the onset of type I diabetes mellitus

1997 • 164 citations

T cell cross-reactivity between coxsackievirus and glutamate decarboxylase is associated with a murine diabetes susceptibility allele.

1994 • 162 citations

The functional significance of epitope spreading and its regulation by co‐stimulatory molecules

1998 • 162 citations

THE EPIDEMIOLOGY OF INSULIN DEPENDENT DIABETES, WITH PARTICULAR REFERENCE TO THE RELATIONSHIP OF VIRUS INFECTION TO ITS ETIOLOGY

1980 • 162 citations

High frequency of cross-reactive cytotoxic T lymphocytes elicited during the virus-induced polyclonal cytotoxic T lymphocyte response.

1993 • 160 citations

Evolution of the T‐Cell Repertoire during the Course of Experimental Immune‐Mediated Demyelinating Diseases

1995 • 158 citations

Accumulation of extracellular matrix and developmental dysregulation in the pancreas by transgenic production of transforming growth factor-beta 1.

1995 • 156 citations

Diabetes Mellitus and Autoimmunity in Patients with the Congenital Rubella Syndrome

1985 • 145 citations

Enteroviruses and Myocarditis: Viral Pathogenesis Through Replication, Cytokine Induction, and Immunopathogenicity

1998 • 144 citations

Theiler's murine encephalomyelitis: a model of demyelination and persistence of virus.

1987 • 141 citations

Viral Infection of Transgenic Mice Expressing a Viral Protein in Oligodendrocytes Leads to Chronic Central Nervous System Autoimmune Disease

1996 • 140 citations

Indications that maternal coxsackie B virus infection during pregnancy is a risk factor for childhood-onset IDDM

1995 • 139 citations

Several different enterovirus serotypes can be associated with prediabetic autoimmune episodes and onset of overt IDDM

1998 • 138 citations

Immunity and immunopathology in dengue virus infections.

1992 • 137 citations

Kinetics of cytokine expression during primary human immunodeficiency virus type 1 infection.

1996 • 136 citations

Myasthenia gravis-like syndrome induced by expression of interferon gamma in the neuromuscular junction.

1995 • 133 citations

Transforming growth factor‐ß₁ in chronic hepatitis C

1997 • 133 citations

Oligodendrocyte-specific expression and autoantigenicity of transaldolase in multiple sclerosis.

1994 • 132 citations

The Role of Viruses and Environmental Factors in the Induction of Diabetes

1990 • 132 citations

Recruitment and proliferation of CD8+ T cells in respiratory virus infections.

1995 • 130 citations

The role of viruses in the pathogenesis of pancreatic disease and diabetes mellitus.

1975 • 127 citations

Cytokine- and virus-stimulated airway smooth muscle cells produce IL-11 and other IL-6-type cytokines

1997 • 125 citations

Anti‐GM₁ IgG antibodies and campylobacter bacteria in Guillain‐Barré syndrome: Evidence of molecular mimicry

1995 • 122 citations

Coxsackievirus B-3 myocarditis. Acute and chronic forms of the disease caused by different immunopathogenic mechanisms.

1987 • 120 citations

Minimal Bystander Activation of CD8 T Cells during the Virus-induced Polyclonal T Cell Response

1997 • 118 citations

Myelin basic protein and human coronavirus 229E cross‐reactive T cells in multiple sclerosis

1996 • 117 citations

IL-10 is necessary and sufficient for autoimmune diabetes in conjunction with NOD MHC homozygosity.

1996 • 105 citations

Molecular mimicry and ankylosing spondylitis: possible role of a novel sequence in pullulanase of Klebsiella pneumoniae

1995 • 101 citations

Interferon-γ in Progression to Chronic Demyelination and Neurological Deficit Following Acute EAE

1998 • 100 citations

Mechanism Underlying Counterregulation of Autoimmune Diabetes by IL-4

1997 • 100 citations

Clinical and experimental aspects of viral myocarditis

1989 • 96 citations

Effects of interferon-gamma on primary cultures of human brain microvessel endothelial cells.

1993 • 94 citations

Triggers of autoimmune disease in a murine TCR-transgenic model for multiple sclerosis.

1997 • 92 citations

Viruses and the Pathogenesis of Diabetes Mellitus

1978 • 90 citations

Autoreactivity in HIV-1 Infection: The Role of Molecular Mimicry

1995 • 88 citations

Virus-Induced Immunoinflammatory Lesions in the Absence of Viral Antigen Recognition

1998 • 87 citations

Viruses and T Cell Turnover: Evidence for Bystander Proliferation

1996 • 77 citations

Detailed in vivo analysis of interferon-gamma induced major histocompatibility complex expression in the the central nervous system: astrocytes fail to express major histocompatibility complex class I and II molecules.

1999 • 76 citations

Interferon-γ: Mechanism of action and therapeutic potential

1990 • 72 citations

Antibodies to Glutamic Acid Decarboxylase and P2-C Peptides in Sera From Coxsackie Virus B4-Infected Mice and IDDM Patients

1994 • 71 citations

Cross-Reactivity Between Streptococcus and Human Tissue: A Model of Molecular Mimicry and Autoimmunity

1989 • 70 citations

A Case-Control Study of Group B Coxsackievirus Immunoglobulin M Antibody Prevalence and HLA-DR Antigens in Newly Diagnosed Cases of Insulin-dependent Diabetes Mellitus

1992 • 59 citations

Local production of human IL-6 promotes insulitis but retards the onset of insulin-dependent diabetes mellitus in non-obese diabetic mice

1994 • 58 citations

The Paradoxical Effects of Interleukin 10 in the Immunoregulation of Autoimmune Diabetes

1996 • 58 citations

IL-10 Impacts Autoimmune Diabetes Via a CD8+ T Cell Pathway Circumventing the Requirement for CD4+ T and B Lymphocytes

1998 • 56 citations

Administering Glutamic Acid Decarboxylase to NOD Mice Prevents Diabetes

1994 • 56 citations

Genetics of autoimmune disease

1995 • 55 citations

Decontamination of Creutzfeldt- Jakob Disease and other transmissible agents

1997 • 54 citations

Focal expression of interleukin-2 does not break unresponsiveness to "self" (viral) antigen expressed in beta cells but enhances development of autoimmune disease (diabetes) after initiation of an anti-self immune response.

1995 • 53 citations

Responses to influenza vaccination in different T-cell subsets: a comparison of healthy young and older adults

1998 • 52 citations

Sensitization to self (virus) antigen by in situ expression of murine interferon-gamma.

1995 • 52 citations

Using Transgenic Mouse Models to Dissect the Pathogenesis of Virus‐Induced Autoimmune Disorders of the Islets of Langerhans and the Central Nervous System

1996 • 48 citations

Enterovirus infections and insulin dependent diabetes mellitus—evidence for causality

1998 • 41 citations

Tissue-specific expression of interleukin-4 induces extracellular matrix accumulation and extravasation of B cells.

1997 • 36 citations

Cytokines up-regulate Ia expression in organotypic cultures of central nervous system tissue

1989 • 36 citations

Binding of the Epstein-Barr virus to human platelets causes the release of transforming growth factor-beta.

1997 • 33 citations

Epitope spreading leads to myelin-specific autoimmune responses in SJL mice chronically infected with Theiler's virus.

1997 • 32 citations

Genes in the MHC that may affect antigen processing

1992 • 32 citations

Apoptosis Defects Analyzed in TcR Transgenic and fas Transgenic Ipr Mice

1994 • 31 citations

Interferon-Mediated Induction of Class I MHC Products in Human Neuronal Cell Lines: Analysis of HLA and β2-m RNA, and HLA-A and HLA-B Proteins and Polymorphic Specificities

1986 • 29 citations

Respiratory syncytial virus G-protein modulates cytokine release from human peripheral blood mononuclear cells

1996 • 28 citations

An interferon-inducible molecule on brain endothelium which controls lymphocyte adhesion mediated by integrins.

1995 • 27 citations

Antibodies to glutamic acid decarboxylase and P2-C peptides in sera from coxsackie virus B4-infected mice and IDDM patients

1994 • 27 citations

Responses of NOD Congenic Mice to a Glutamic Acid Decarboxylase-derived Peptide

1994 • 26 citations

Molecular Mimicry

1994 • 24 citations

A Role for Transforming Growth Factor-β1 in the Increased Pneumonitis in Murine Allogeneic Bone Marrow Transplant Recipients With Graft-Versus-Host Disease After Pulmonary Herpes Simplex Virus Type 1 Infection

1998 • 24 citations

Upper respiratory tract infections trigger attacks of multiple sclerosis in patients treated with interferon

1991 • 21 citations

Virus‐Induced Autoimmunity Through Molecular Mimicrya

1988 • 20 citations

Secondary immune amplification following live poliovirus immunization in humans

1987 • 13 citations

Shock revelations about HLA–DR4 — a shortcut to rheumatoid arthritis?

1996 • 11 citations

Abortion access resisted in USA

1994 • 1 citations