Inflammatory Cytokines and Postmyocardial Infarction Remodeling

Effect of Captopril on Mortality and Morbidity in Patients with Left Ventricular Dysfunction after Myocardial Infarction

1992 • 5,885 citations

An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

1996 • 3,094 citations

Neovascularization of ischemic myocardium by human bone-marrow–derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function

2001 • 2,583 citations

Left ventricular end-systolic volume as the major determinant of survival after recovery from myocardial infarction.

1987 • 2,347 citations

NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase

1999 • 2,147 citations

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

1996 • 1,962 citations

The inflammatory response in myocardial infarction

2002 • 1,941 citations

The Receptor for the Cytotoxic Ligand TRAIL

1997 • 1,755 citations

An Antagonist Decoy Receptor and a Death Domain-Containing Receptor for TRAIL

1997 • 1,506 citations

TUMOR NECROSIS FACTOR RECEPTOR AND Fas SIGNALING MECHANISMS

1999 • 1,309 citations

A novel domain within the 55 kd TNF receptor signals cell death

1993 • 1,302 citations

Apoptosis control by death and decoy receptors

1999 • 1,296 citations

MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1

1997 • 1,294 citations

Dilated Cardiomyopathy in Transgenic Mice With Cardiac-Specific Overexpression of Tumor Necrosis Factor-α

1997 • 830 citations

Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failure

1999 • 790 citations

Interleukin 6 and its Receptor: Ten Years Later

1998 • 774 citations

Tumor necrosis factor alpha-induced apoptosis in cardiac myocytes. Involvement of the sphingolipid signaling cascade in cardiac cell death.

1996 • 742 citations

IL-6-Induced Homodimerization of gp130 and Associated Activation of a Tyrosine Kinase

1993 • 730 citations

Inflammatory Markers and Risk of Heart Failure in Elderly Subjects Without Prior Myocardial Infarction

2003 • 709 citations

Cellular basis for the negative inotropic effects of tumor necrosis factor-alpha in the adult mammalian heart.

1993 • 708 citations

Early Expression of Angiogenesis Factors in Acute Myocardial Ischemia and Infarction

2000 • 689 citations

Signal Transduction by DR3, a Death Domain-Containing Receptor Related to TNFR-1 and CD95

1996 • 653 citations

The role of neutrophils in myocardial ischemia–reperfusion injury

1999 • 642 citations

TNF receptor subtype signalling: Differences and cellular consequences

2002 • 603 citations

Cardiac Failure in Transgenic Mice With Myocardial Expression of Tumor Necrosis Factor-α

1998 • 602 citations

Recombinant human erythropoietin protects the myocardium from ischemia-reperfusion injury and promotes beneficial remodeling

2003 • 601 citations

Matrix Metalloproteinase Inhibition After Myocardial Infarction

2001 • 596 citations

Aldosterone-Induced Inflammation in the Rat Heart

2002 • 564 citations

Inhibitory Effects of Antioxidants on Neonatal Rat Cardiac Myocyte Hypertrophy Induced by Tumor Necrosis Factor-α and Angiotensin II

1998 • 509 citations

Continuous activation of gp130, a signal-transducing receptor component for interleukin 6-related cytokines, causes myocardial hypertrophy in mice.

1995 • 504 citations

Interleukin-1β and Tumor Necrosis Factor-α Decrease Collagen Synthesis and Increase Matrix Metalloproteinase Activity in Cardiac Fibroblasts In Vitro

2000 • 486 citations

Myocyte renewal and ventricular remodelling

2002 • 474 citations

A Matrix Metalloproteinase Induction/Activation System Exists in the Human Left Ventricular Myocardium and Is Upregulated in Heart Failure

2000 • 470 citations

Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain

1999 • 459 citations

Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway.

1994 • 459 citations

Activation of SAPK/JNK by TNF Receptor 1 Through a Noncytotoxic TRAF2-Dependent Pathway

1997 • 454 citations

Peroxynitrite Is a Major Contributor to Cytokine-Induced Myocardial Contractile Failure

2000 • 448 citations

Matrix Metalloproteinase Inhibition Attenuates Early Left Ventricular Enlargement After Experimental Myocardial Infarction in Mice

1999 • 440 citations

Interleukin-6 Induces Oxidative Stress and Endothelial Dysfunction by Overexpression of the Angiotensin II Type 1 Receptor

2003 • 436 citations

Tumor necrosis factor-alpha gene and protein expression in adult feline myocardium after endotoxin administration.

1995 • 436 citations

Cytokine Gene Expression After Myocardial Infarction in Rat Hearts

1998 • 418 citations

Oxidative Stress Mediates Tumor Necrosis Factor-α–Induced Mitochondrial DNA Damage and Dysfunction in Cardiac Myocytes

2003 • 410 citations

Impaired cutaneous wound healing in interleukin‐6‐deficient and immunosuppressed mice

2000 • 400 citations

FAN, a Novel WD-Repeat Protein, Couples the p55 TNF-Receptor to Neutral Sphingomyelinase

1996 • 390 citations

PR39, a peptide regulator of angiogenesis

2000 • 383 citations

TNF ligands and receptors – a matter of life and death

2002 • 376 citations

Left Ventricular Remodeling in Transgenic Mice With Cardiac Restricted Overexpression of Tumor Necrosis Factor

2001 • 375 citations

Tumor Necrosis Factor-α Provokes a Hypertrophic Growth Response in Adult Cardiac Myocytes

1997 • 364 citations

Tissue Expression and Immunolocalization of Tumor Necrosis Factor-α in Postinfarction Dysfunctional Myocardium

1999 • 359 citations

TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling

1998 • 327 citations

Sphingosine Mediates the Immediate Negative Inotropic Effects of Tumor Necrosis Factor-α in the Adult Mammalian Cardiac Myocyte

1997 • 324 citations

Myocardial extracellular matrix remodeling in transgenic mice overexpressing tumor necrosis factor α can be modulated by anti-tumor necrosis factor α therapy

2000 • 319 citations

Cardiac Myocytes Produce Interleukin-6 in Culture and in Viable Border Zone of Reperfused Infarctions

1999 • 318 citations

Cardiomyocyte apoptosis and ventricular remodeling after myocardial infarction in rats

2001 • 299 citations

Induction of Interleukin-6 Synthesis in the Myocardium

1995 • 298 citations

In Vivo Myocardial Protection From Ischemia/Reperfusion Injury by the Peroxisome Proliferator–Activated Receptor-γ Agonist Rosiglitazone

2001 • 297 citations

Cardiac cytokine expression is upregulated in the acute phase after myocardial infarction. Experimental studies in rats

2002 • 294 citations

Stress-Activated Cytokines and The Heart: From Adaptation to Maladaptation

2003 • 291 citations

Exaggerated Left Ventricular Dilation and Reduced Collagen Deposition After Myocardial Infarction in Mice Lacking Osteopontin

2001 • 291 citations

Hemodynamic Regulation of Tumor Necrosis Factor-α Gene and Protein Expression in Adult Feline Myocardium

1997 • 284 citations

Robert Feulgen Lecture 1998

1999 • 284 citations

Regulated Commitment of TNF Receptor Signaling

1999 • 282 citations

Pioglitazone, a Peroxisome Proliferator–Activated Receptor-γ Agonist, Attenuates Left Ventricular Remodeling and Failure After Experimental Myocardial Infarction

2002 • 255 citations

Time course of left ventricular dilation after myocardial infarction: Influence of infarct-related artery and success of coronary thrombolysis

1988 • 243 citations

Changes in Extracellular Matrix and in Transforming Growth Factor Beta Isoforms After Coronary Artery Ligation in Rats

2001 • 199 citations

Selective Matrix Metalloproteinase Inhibition Reduces Left Ventricular Remodeling but Does Not Inhibit Angiogenesis After Myocardial Infarction

2002 • 187 citations

Stem Cell Factor Induction Is Associated With Mast Cell Accumulation After Canine Myocardial Ischemia and Reperfusion

1998 • 174 citations

Induction of Monocyte Chemoattractant Protein-1 in the Small Veins of the Ischemic and Reperfused Canine Myocardium

1997 • 173 citations

Cardiac-specific overexpression of tumor necrosis factor-alpha causes lethal myocarditis in transgenic mice

1997 • 161 citations

Free radicals enhance Na+/Ca2+ exchange in ventricular myocytes

1996 • 153 citations

Tumor Necrosis Factor-α–Induced AT ₁ Receptor Upregulation Enhances Angiotensin II–Mediated Cardiac Fibroblast Responses That Favor Fibrosis

2002 • 147 citations

Neutralization of interleukin-1β in the acute phase of myocardial infarction promotes the progression of left ventricular remodeling

2001 • 141 citations

Beneficial Effects of Long-Term Use of the Antioxidant Probucol in Heart Failure in the Rat

2002 • 135 citations

Cytokine expression increases in nonmyocytes from rats with postinfarction heart failure

1998 • 125 citations

Temporal Response and Localization of Integrins β1 and β3 in the Heart After Myocardial Infarction

2003 • 121 citations

TNFα receptor expression in rat cardiac myocytes: TNFα inhibition of L‐type Ca²⁺ current and Ca²⁺ transients

1995 • 121 citations

Hydrogen peroxide induces tumor necrosis factor α–mediated cardiac injury by a P38 mitogen-activated protein kinase–dependent mechanism

1998 • 114 citations

Superoxide attenuates macrophage apoptosis by NF-kappa B and AP-1 activation that promotes cyclooxygenase-2 expression.

1999 • 110 citations

Modulation of oxidative stress by a selective inhibition of angiotensin II type 1 receptors in MI rats

2001 • 105 citations

Ceramide generation by two distinct pathways in tumor necrosis factor α‐induced cell death

2001 • 105 citations

Elevation of Vascular Endothelial Growth Factor-A Serum Levels Following Acute Myocardial Infarction. Evidence for its Origin and Functional Significance

2000 • 96 citations

Myosin Light Chain Phosphorylation in Neutrophil-Stimulated Coronary Microvascular Leakage

2002 • 95 citations

Tumor Necrosis Factor-α Mediates Both Apoptotic Cell Death and Cell Proliferation in a Human Hematopoietic Cell Line Dependent on Mitotic Activity and Receptor Subtype Expression

1999 • 94 citations

Roles and Relationship of Macrophages and Monocyte Chemotactic and Activating Factor/Monocyte Chemoattractant Protein-1 in the Ischemic and Reperfused Rat Heart

2000 • 93 citations

Superoxide Attenuates Macrophage Apoptosis by NF-κB and AP-1 Activation That Promotes Cyclooxygenase-2 Expression

1999 • 87 citations

Improved post-myocardial infarction survival with probucol in rats: Effects on left ventricular function, morphology, cardiac oxidative stress and cytokine expression

2002 • 86 citations

Osteopontin Inhibits Interleukin-1β-stimulated Increases in Matrix Metalloproteinase Activity in Adult Rat Cardiac Fibroblasts

2003 • 75 citations

Which patient benefits from early angiotensin-converting enzyme inhibition after myocardial infarction? Results of one-year serial echocardiographic follow-up from the captopril and thrombolysis study (CATS)

1996 • 75 citations

A serine elastase inhibitor reduces inflammation and fibrosis and preserves cardiac function after experimentally-induced murine myocarditis

1998 • 66 citations

Guanidinoethyl sulphonate is a glycine receptor antagonist in striatum

2002 • 59 citations

Pleiotropic Effects of Cytokines on Acute Myocardial Infarction: G-CSF as A Novel Therapy for Acute Myocardial Infarction

2003 • 53 citations

Relation between expression of TNF alpha, iNOS, VEGF mRNA and development of heart failure after experimental myocardial infarction in rats.

2001 • 50 citations

Interleukin-6 and tumor necrosis factor alpha in relation to myocardial infarct size and collagen formation

2003 • 47 citations

Overexpression of tumor necrosis factor-α increases production of hydroxyl radical in murine myocardium

2003 • 46 citations

Elafin-overexpressing mice have improved cardiac function after myocardial infarction

2004 • 43 citations

Subacute and Chronic Effects of Quinapril on Cardiac Cytokine Expression, Remodeling, and Function After Myocardial Infarction in the Rat

2002 • 34 citations

Long-Term Effects of Carvedilol on Left Ventricular Function, Remodeling, and Expression of Cardiac Cytokines After Large Myocardial Infarction in the Rat

2002 • 28 citations

Induction of left ventricular remodeling and dysfunction in the recipient heart after donor heart myocardial infarction

2003 • 24 citations