A serine elastase inhibitor reduces inflammation and fibrosis and preserves cardiac function after experimentally-induced murine myocarditis

Measurement of Cutaneous Inflammation: Estimation of Neutrophil Content with an Enzyme Marker

1982 • 3,566 citations

Neutrophil-mediated endothelial injury in vitro mechanisms of cell detachment.

1981 • 446 citations

Clinicopathoiogic description of myocarditis

1991 • 337 citations

Enhancement of recovery of myocardial function by oxygen free-radical scavengers after reversible regional ischemia.

1985 • 324 citations

Microvascular spasm in the cardiomyopathic Syrian hamster: a preventable cause of focal myocardial necrosis.

1982 • 295 citations

The induction of 72-kD gelatinase in T cells upon adhesion to endothelial cells is VCAM-1 dependent.

1994 • 250 citations

Interleukin 1 or tumor necrosis factor can promote Coxsackie B3-induced myocarditis in resistant B10.A mice.

1992 • 207 citations

Novel organ-specific circulating cardiac autoantibodies in dilated cardiomyopathy

1990 • 200 citations

An animal model of congestive (dilated) cardiomyopathy: dilatation and hypertrophy of the heart in the chronic stage in DBA/2 mice with myocarditis caused by encephalomyocarditis virus.

1982 • 194 citations

Circulating heart-reactive antibodies in patients with myocarditis or cardiomyopathy

1990 • 192 citations

Increased neutrophil elastase release in unstable angina pectoris and acute myocardial infarction

1990 • 186 citations

Elastase and cathepsin G of human monocytes. Quantification of cellular content, release in response to stimuli, and heterogeneity in elastase-mediated proteolytic activity.

1989 • 185 citations

Disruption of the subendothelial basement membrane during neutrophil diapedesis in an in vitro construct of a blood vessel wall.

1989 • 183 citations

Therapeutic effect of anti-tumor necrosis factor-alpha antibody on the murine model of viral myocarditis induced by encephalomyocarditis virus.

1994 • 160 citations

Characterization of collagen from normal human sclera

1984 • 149 citations

Exogenous leukocyte and endogenous elastases can mediate mitogenic activity in pulmonary artery smooth muscle cells by release of extracellular matrix-bound basic fibroblast growth factor

1996 • 147 citations

Reperfusion-induced leukocyte infiltration: role of elastase

1990 • 137 citations

Elastase of U-937 Monocytelike Cells

1982 • 126 citations

A nonsteroid anti-inflammatory drug exacerbates coxsackie B3 murine myocarditis

1985 • 115 citations

Cytotoxic T lymphocyte mediated cytolysis

1988 • 99 citations

Therapy With Immunoglobulin Suppresses Myocarditis in a Murine Coxsackievirus B3 Model

1995 • 98 citations

Verapamil ameliorates the clinical and pathological course of murine myocarditis.

1992 • 88 citations

Beneficial effects of captopril in acute coxsackievirus B3 murine myocarditis.

1990 • 83 citations

Expression of perforin in infiltrating cells in murine hearts with acute myocarditis caused by coxsackievirus B3.

1991 • 77 citations

Elafin, a serine elastase inhibitor, attenuates post-cardiac transplant coronary arteriopathy and reduces myocardial necrosis in rabbits afer heterotopic cardiac transplantation.

1996 • 74 citations

Orally Active Trifluoromethyl Ketone Inhibitors of Human Leukocyte Elastase

1997 • 69 citations

Beta-blocker treatment of dilated cardiomyopathy. Beneficial effect of carteolol in mice.

1991 • 64 citations

Inhibition of proteolytic activity of poliovirus and rhinovirus 2A proteinases by elastase-specific inhibitors

1993 • 62 citations

The Prevalence of Encephalomyocarditis Virus Neutralizing Antibodies among Various Human Populations

1978 • 58 citations

Discovery and Biological Activity of Orally Active Peptidyl Trifluoromethyl Ketone Inhibitors of Human Neutrophil Elastase

1997 • 51 citations

In vivo significance of T cells in the development of Coxsackievirus B3 myocarditis in mice. Immature but antigen-specific T cells aggravate cardiac injury.

1990 • 50 citations

Post-cardiac transplant arteriopathy in piglets is associated with fragmentation of elastin and increased activity of a serine elastase.

1994 • 44 citations

Depletion of Mac1-positive macrophages protects DBA/2 mice from encephalomyocarditis virus-induced myocarditis and diabetes

1996 • 39 citations

Effects of synthesized elastin peptides on human leukocytes.

1995 • 37 citations

Evaluation of the effects of low molecular weight heparin on inflammation and collagen deposition in chronic coxsackievirus B3-induced myocarditis in A/J mice.

1992 • 36 citations

Immunosuppression with high doses of cyclophosphamide reduces the severity of myocarditis but increases the mortality in murine Coxsackievirus B3 myocarditis.

1990 • 34 citations

Role of Neutrophil Depletion and Elastase Inhibition in Modifying Skeletal Muscle Reperfusion Injury

1994 • 31 citations

Coronary microvascular narrowing in acute murine coxsackie B3 myocarditis

1989 • 30 citations

Inhibition of elastase improves myocardial function after repetitive ischaemia and myocardial infarction in the rat heart

1997 • 30 citations

Leukocyte elastase inhibition and t-PA-induced coronary artery thrombolysis in dogs: Beneficial effects on myocardial histology

1991 • 29 citations

Absence of effects of cyclosporine on myocardial lymphocyte subsets in Coxsackievirus B3 myocarditis in the aviremic stage.

1989 • 18 citations

Viral myocarditis: Changing concepts in pathogenesis and implications in diagnosis and treatment

1993 • 9 citations

The effect of .ALPHA.1-blocker, bunazosin on a murine model of congestive heart failure induced by viral myocarditis.

1992 • 9 citations