The use of yeast artificial chromosomes in transgenic animals: expression studies of the tyrosinase gene in transgenic mice

Position-independent, high-level expression of the human β-globin gene in transgenic mice

1987 • 1,955 citations

GERM-LINE TRANSFORMATION OF MICE

1986 • 1,165 citations

A 5′ element of the chicken β-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila

1993 • 858 citations

Position Effects on Eukaryotic Gene Expression

1990 • 377 citations

Locus Control Region Function and Heterochromatin-Induced Position Effect Variegation

1996 • 373 citations

Enhancers increase the probability but not the level of gene expression.

1995 • 293 citations

Matrix-attachment regions can impart position-independent regulation of a tissue-specific gene in transgenic mice.

1992 • 288 citations

MOLECULAR AND DEVELOPMENTAL GENETICS OF MOUSE COAT COLOR

1994 • 280 citations

A yeast artificial chromosome covering the tyrosinase gene confers copy number-dependent expression in transgenic mice

1993 • 275 citations

Transcriptional regulation of multigene loci: multilevel control

1993 • 187 citations

Rescue of the albino phenotype by introduction of a functional tyrosinase gene into mice.

1990 • 182 citations

Locus control regions: overcoming heterochromatin-induced gene inactivation in mammals

1997 • 148 citations

Variegated gene expression in mice

1997 • 116 citations

A cell-specific enhancer far upstream of the mouse tyrosinase gene confers high level and copy number-related expression in transgenic mice.

1994 • 116 citations

Expression of the mouse tyrosinase gene during embryonic development: recapitulation of the temporal regulation in transgenic mice.

1992 • 107 citations

Chromatin structure and gene activity

1990 • 100 citations

A locus control region at −12 kb of the tyrosinase gene.

1996 • 85 citations

Mutagenesis of the human apolipoprotein B gene in a yeast artificial chromosome reveals the site of attachment for apolipoprotein(a).

1995 • 79 citations

A Globin Enhancer Acts by Increasing the Proportion of Erythrocytes Expressing a Linked Transgene

1997 • 77 citations

Production of transgenic mice with yeast artificial chromosomes

1997 • 76 citations

Chromatin domains as potential units of eukaryotic gene function

1994 • 72 citations

Correction of retinal abnormalities found in albinism by introduction of a functional tyrosinase gene in transgenic mice and rabbits

1997 • 65 citations

Correction of Abnormal Retinal Pathways Found with Albinism by Introduction of a Functional Tyrosinase Gene in Transgenic Mice

1994 • 59 citations

YAC transgenics and the study of genetics and human disease

1995 • 57 citations

Transcriptional regulation in endoderm development: characterization of an enhancer controlling Hnf3g expression by transgenesis and targeted mutagenesis

1997 • 43 citations

Molecular Characterization of the Mouse Tyrosinase Gene:Pigment Cell‐Specific Expression in Transgenic Mice

1992 • 21 citations

Germ line transmission of yeast artificial chromosomes in transgenic mice

1994 • 20 citations