Inhibition of Autophagy and Multiple Steps in Asialoglycoprotein Endocytosis by Inhibitors of Tyrosine Protein Kinases (Tyrphostins)

Chapter 4 Preparation of Isolated Rat Liver Cells

1976 • 5,335 citations

A new method of preparing gold probes for multiple-labeling cytochemistry.

1985 • 1,417 citations

Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism

1989 • 848 citations

Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors

1989 • 607 citations

Blocking of EGF-Dependent Cell Proliferation by EGF Receptor Kinase Inhibitors

1988 • 593 citations

Characterization of the early endosome and putative endocytic carrier vesicles in vivo and with an assay of vesicle fusion in vitro.

1989 • 588 citations

Movement of internalized ligand–receptor complexes along a continuous endosomal reticulum

1990 • 428 citations

Late endosomes derive from early endosomes by maturation

1991 • 311 citations

Immunocytochemical characterization of the endocytic and phagolysosomal compartments in peritoneal macrophages.

1992 • 277 citations

Phosphorylation of the Polymeric Immunoglobulin Receptor Required for Its Efficient Transcytosis

1990 • 267 citations

Association of p60c-src with endosomal membranes in mammalian fibroblasts.

1992 • 233 citations

Inhibition of endocytic vesicle fusion in vitro by the cell-cycle control protein kinase cdc2

1989 • 167 citations

Characterization of the cation-independent mannose 6-phosphate receptor-enriched prelysosomal compartment in NRK cells

1990 • 161 citations

Tyrosine kinase inhibitors block calcium channel currents in vascular smooth muscle cells

1992 • 148 citations

The tyrosine kinase inhibitor tyrphostin blocks the cellular actions of nerve growth factor

1993 • 113 citations

Effects of amino acids, ammonia and leupeptin on protein synthesis and degradation in isolated rat hepatocytes

1978 • 101 citations

Binding of pp170 to microtubules is regulated by phosphorylation.

1991 • 101 citations

Protein kinase-dependent effects of okadaic acid on hepatocytic autophagy and cytoskeletal integrity

1992 • 96 citations

A role for microtubules in sorting endocytic vesicles in rat hepatocytes.

1992 • 88 citations

Cell-free fusion of endocytic vesicles is regulated by phosphorylation.

1992 • 87 citations

Inhibition of hepatocytic autophagy by okadaic acid and other protein phosphatase inhibitors

1993 • 87 citations

Related signals for endocytosis and basolateral sorting of the asialoglycoprotein receptor.

1993 • 82 citations

Intracellular transport of asialoglycoproteins in rat hepatocytes

1985 • 76 citations

The inhibition of EGF-dependent proliferation of keratinocytes by tyrphostin tyrosine kinase blockers.

1991 • 75 citations

Asialoglycoprotein receptor phosphorylation and receptor-mediated endocytosis in hepatoma cells. Effect of phorbol esters.

1988 • 69 citations

Effects of tyrosine kinase inhibitors on protein kinase‐independent systems

1993 • 54 citations

Membrane boundaries involved in the uptake and intracellular processing of cell surface receptors

1986 • 50 citations

Use of [3H]raffinose as a specific probe of autophagic sequestration

1986 • 48 citations

Inhibition of platelet-derived growth factor-induced mitogenesis and tyrosine kinase activity in cultured bone marrow fibroblasts by tyrphostins

1992 • 44 citations

Conversion of dense lysosomes into light lysosomes during hepatocytic autophagy

1985 • 32 citations

Defective asialoglycoprotein receptor endocytosis mediated by tyrosine kinase inhibitors. Requirement for a tyrosine in the receptor internalization signal

1994 • 31 citations

The effect of vanadate on receptor-mediated endocytosis of asialoorosomucoid in rat liver parenchymal cells.

1990 • 27 citations

The asialoglycoprotein receptor is associated with a tyrosine kinase in HepG2 cells.

1994 • 21 citations

Organelle-specific phosphorylation. Identification of unique membrane phosphoproteins of the endoplasmic reticulum and endosomal apparatus.

1993 • 20 citations

Intracellular degradation of asialoglycoproteins in hepatocytes starts in a subgroup of lysosomes

1985 • 19 citations

An inhibitory effect of a protein kinase inhibitor, staurosporine, on delivery of endocytosed asialoglycoprotein to lysosome in monolayer culture of rat hepatocytes

1991 • 9 citations

Endocytic Components: Identification and Characterization

1993 • 8 citations