Asialoglycoprotein receptor phosphorylation and receptor-mediated endocytosis in hepatoma cells. Effect of phorbol esters.

A Flexible System of Enzymatic Analysis

1972 • 4,133 citations

Staurosporine, a potent inhibitor of phospholipidCa++dependent protein kinase

1986 • 2,445 citations

Intracellular site of asialoglycoprotein receptor-ligand uncoupling: Double-label immunoelectron microscopy during receptor-mediated endocytosis

1983 • 816 citations

Regulation of transmembrane signaling by receptor phosphorylation

1987 • 678 citations

Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor.

1986 • 650 citations

Phosphorylation activates the insulin receptor tyrosine protein kinase.

1983 • 558 citations

The galactose-specific recognition system of mammalian liver: The route of ligand internalization in rat hepatocytes

1980 • 484 citations

Kinetics of internalization and recycling of the asialoglycoprotein receptor in a hepatoma cell line.

1982 • 357 citations

Epidermal growth factor and potent phorbol tumor promoters induce epidermal growth factor receptor phosphorylation in a similar but distinctively different manner in human epidermoid carcinoma A431 cells.

1984 • 331 citations

Protein kinase C phosphorylation at Thr 654 of the unoccupied EGF receptor and EGF binding regulate functional receptor loss by independent mechanisms

1986 • 325 citations

Phosphorylation of the mammalian beta-adrenergic receptor by cyclic AMP-dependent protein kinase. Regulation of the rate of receptor phosphorylation and dephosphorylation by agonist occupancy and effects on coupling of the receptor to the stimulatory guanine nucleotide regulatory protein.

1985 • 312 citations

Phorbol esters modulate insulin receptor phosphorylation and insulin action in cultured hepatoma cells.

1984 • 260 citations

Phorbol ester induces desensitization of adenylate cyclase and phosphorylation of the beta-adrenergic receptor in turkey erythrocytes.

1984 • 233 citations

Association of phorbol ester-induced hyperphosphorylation and reversible regulation of transferrin membrane receptors in HL60 cells.

1984 • 225 citations

Rapid internalization of the transferrin receptor in K562 cells is triggered by ligand binding or treatment with a phorbol ester.

1984 • 206 citations

Phorbol esters induce transient internalization without degradation of unoccupied epidermal growth factor receptors.

1985 • 199 citations

Endocytosis of the transferrin receptor requires the cytoplasmic domain but not its phosphorylation site

1987 • 192 citations

Recycling of the asialoglycoprotein receptor and the effect of lysosomotropic amines in hepatoma cells.

1984 • 188 citations

The Hepatic Asialoglycoprotein Recepto

1984 • 185 citations

Intracellular dissociation of receptor-bound asialoglycoproteins in cultured hepatocytes. A pH-mediated nonlysosomal event.

1983 • 176 citations

The asialoglycoprotein receptor internalizes and recycles independently of the transferrin and insulin receptors

1983 • 161 citations

Rapid acidification of endocytic vesicles containing asialoglycoprotein in cells of a human hepatoma line.

1983 • 155 citations

Ion-exchange thin-layer chromatography

1965 • 140 citations

Difficulties in the quantification of asialoglycoprotein receptors on the rat hepatocyte.

1980 • 123 citations

Biosynthesis of the human asialoglycoprotein receptor.

1983 • 119 citations

Identification of mannose 6-phosphate receptors in rabbit alveolar macrophages.

1984 • 67 citations

Regulation of transferrin receptor cycling by protein kinase C is independent of receptor phosphorylation at serine 24 in Swiss 3T3 fibroblasts.

1987 • 66 citations

Mechanism of insulin action on membrane protein recycling: a selective decrease in the phosphorylation state of insulin-like growth factor II receptors in the cell surface membrane.

1985 • 66 citations

Regulation by phorbol esters of asialoglycoprotein and transferrin receptor distribution and ligand affinity in a hepatoma cell line.

1986 • 63 citations

Phosphorylation of the human transferrin receptor by protein kinase C is not required for endocytosis and recycling in mouse 3T3 cells.

1987 • 53 citations

Ligand- and weak base-induced redistribution of asialoglycoprotein receptors in hepatoma cells.

1987 • 51 citations

Antibody-induced receptor loss. Different fates for asialoglycoproteins and the asialoglycoprotein receptor in HepG2 cells.

1986 • 43 citations

Intracellular transport of class I histocompatibility molecules. Influence of protein folding on transport to the cell surface.

1988 • 42 citations

Phosphorylation of the surface transferrin receptor stimulates receptor internalization in HL60 leukemic cells.

1987 • 42 citations

Cellular pathways of galactose-terminal ligand movement in a cloned human hepatoma cell line.

1984 • 40 citations

Phosphorylation of the human asialoglycoprotein receptor

1984 • 27 citations

Ligand-induced modulation of the hepatic receptor for asialoglycoproteins in the human hepatoblastoma cell line, Hep G2.

1987 • 22 citations

Intracytoplasmic phosphorylation sites of Tac antigen (p55) are not essential for the conformation, function, and regulation of the human interleukin 2 receptor.

1986 • 22 citations

Mechanism of the phorbol ester-mediated redistribution of asialoglycoprotein receptor: selective effects on receptor recycling pathways in Hep G2 cells.

1987 • 20 citations

Early effect of growth factors (EGF+insulin) upon ATP turnover in 3T3 cells

1983 • 15 citations