Recycling the Cell Cycle

CDK inhibitors: positive and negative regulators of G1-phase progression

1999 • 6,003 citations

Cyclin is degraded by the ubiquitin pathway

1991 • 2,355 citations

DNA Replication in Eukaryotic Cells

2002 • 2,017 citations

The Cell in Development and Heredity

1925 • 1,750 citations

Genetic Control of the Cell Division Cycle in Yeast

1974 • 1,588 citations

Cytoplasmic control of nuclear behavior during meiotic maturation of frog oocytes

1971 • 1,553 citations

Robustness in simple biochemical networks

1997 • 1,531 citations

Cyclin: A protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division

1983 • 1,506 citations

The RAD9 Gene Controls the Cell Cycle Response to DNA Damage in Saccharomyces cerevisiae

1988 • 1,174 citations

Robustness in bacterial chemotaxis

1999 • 1,147 citations

The role of cyclin synthesis and degradation in the control of maturation promoting factor activity

1989 • 1,114 citations

A chemical switch for inhibitor-sensitive alleles of any protein kinase

2000 • 1,032 citations

Targets of the cyclin-dependent kinase Cdk1

2003 • 896 citations

Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16

1995 • 894 citations

The Anaphase-Promoting Complex

2002 • 885 citations

Purified maturation-promoting factor contains the product of a Xenopus homolog of the fission yeast cell cycle control gene cdc2+

1988 • 885 citations

Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport.

1991 • 858 citations

Genetic control of cell size at cell division in yeast

1975 • 846 citations

The Xenopus cdc2 protein is a component of MPF, a cytoplasmic regulator of mitosis

1988 • 829 citations

Self-organization of microtubules and motors

1997 • 824 citations

CDC20 and CDH1 : A Family of Substrate-Specific Activators of APC-Dependent Proteolysis

1997 • 809 citations

Radiosensitivity in ataxia-telangiectasia: a new explanation.

1980 • 784 citations

In vitro disassembly of the nuclear lamina and M phase-specific phosphorylation of lamins by cdc2 kinase

1990 • 783 citations

Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice

2003 • 781 citations

The Cell in Development and Heredity

1925 • 767 citations

Dominoes and Clocks: the Union of Two Views of the Cell Cycle

1989 • 750 citations

Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function.

1994 • 731 citations

The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1

2000 • 713 citations

Temporal and spatial control of cyclin B1 destruction in metaphase

1999 • 685 citations

Whose end is destruction: cell division and the anaphase-promoting complex

1999 • 679 citations

Cyclin is a component of maturation-promoting factor from Xenopus

1990 • 674 citations

cdc2 protein kinase is complexed with both cyclin A and B: Evidence for proteolytic inactivation of MPF

1989 • 666 citations

Mutations of phosphorylation sites in lamin A that prevent nuclear lamina disassembly in mitosis

1990 • 642 citations

Cyclin E Ablation in the Mouse

2003 • 640 citations

Purification of maturation-promoting factor, an intracellular regulator of early mitotic events.

1988 • 640 citations

The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases

2000 • 634 citations

Formation in Vitro of Sperm Pronuclei and Mitotic Chromosomes Induced by Amphibian Ooplasmic Components

1983 • 630 citations

An Ultrasensitive Bacterial Motor Revealed by Monitoring Signaling Proteins in Single Cells

2000 • 604 citations

Physical Properties Determining Self-Organization of Motors and Microtubules

2001 • 592 citations

The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation

1998 • 590 citations

The WHI1+ gene of Saccharomyces cerevisiae tethers cell division to cell size and is a cyclin homolog.

1988 • 563 citations

MPF from starfish oocytes at first meiotic metaphase is a heterodimer containing one molecule of cdc2 and one molecule of cyclin B.

1989 • 550 citations

Segregating Sister Genomes: The Molecular Biology of Chromosome Separation

2002 • 549 citations

cdc2 is a component of the M phase-specific histone H1 kinase: Evidence for identity with MPF

1988 • 535 citations

The clam embryo protein cyclin A induces entry into M phase and the resumption of meiosis in Xenopus oocytes

1986 • 534 citations

Receptor sensitivity in bacterial chemotaxis

2001 • 534 citations

The spindle checkpoint: structural insights into dynamic signalling

2002 • 526 citations

Control of Cyclin Ubiquitination by CDK-Regulated Binding of Hct1 to the Anaphase Promoting Complex

1998 • 521 citations

SIGNAL TRANSDUCTION PATHWAYS INVOLVING PROTEIN PHOSPHORYLATION IN PROKARYOTES

1991 • 512 citations

Direct Binding of CDC20 Protein Family Members Activates the Anaphase-Promoting Complex in Mitosis and G1

1998 • 484 citations

Yeast Hct1 Is a Regulator of Clb2 Cyclin Proteolysis

1997 • 479 citations

Closing the cell cycle circle in yeast: G2 cyclin proteolysis initiated at mitosis persists until the activation of G1 cyclins in the next cycle

1994 • 478 citations

Phosphorylation of Sic1p by G ₁ Cdk Required for Its Degradation and Entry into S Phase

1997 • 454 citations

DAF1, a mutant gene affecting size control, pheromone arrest, and cell cycle kinetics of Saccharomyces cerevisiae.

1988 • 445 citations

Translation of cyclin mRNA is necessary for extracts of activated Xenopus eggs to enter mitosis

1989 • 438 citations

Identification of cell cycle-regulated phosphorylation sites on nuclear lamin C

1990 • 425 citations

Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14

1999 • 417 citations

A family of cyclin homologs that control the G1 phase in yeast.

1989 • 416 citations

Engineering unnatural nucleotide specificity for Rous sarcoma virus tyrosine kinase to uniquely label its direct substrates

1997 • 415 citations

Anaphase-Promoting Complex/Cyclosome–Dependent Proteolysis of Human Cyclin a Starts at the Beginning of Mitosis and Is Not Subject to the Spindle Assembly Checkpoint

2001 • 413 citations

The spindle checkpoint

1999 • 408 citations

A MAP kinase-dependent spindle assembly checkpoint in Xenopus egg extracts

1994 • 402 citations

Regulation of Chromosome Replication

2000 • 402 citations

The interaction of steroids with Rana pipiens oocytes in the induction of maturation

1971 • 400 citations

Control of mitosis by changes in the subcellular location of cyclin-B1–Cdk1 and Cdc25C

2000 • 384 citations

Emi1 Is a Mitotic Regulator that Interacts with Cdc20 and Inhibits the Anaphase Promoting Complex

2001 • 383 citations

Cyclin E-induced S phase without activation of the pRb/E2F pathway.

1997 • 381 citations

A cytoplasmic clock with the same period as the division cycle in Xenopus eggs.

1980 • 358 citations

Substrate recruitment to cyclin-dependent kinase 2 by a multipurpose docking site on cyclin A

1998 • 355 citations

Control of Meiotic and Mitotic Progression by the F Box Protein β-Trcp1 In Vivo

2003 • 346 citations

APCCdc20 promotes exit from mitosis by destroying the anaphase inhibitor Pds1 and cyclin Clb5

1999 • 346 citations

Rescue of Cyclin D1 Deficiency by Knockin Cyclin E

1999 • 340 citations

Prophase Destruction of Emi1 by the SCFβTrCP/Slimb Ubiquitin Ligase Activates the Anaphase Promoting Complex to Allow Progression beyond Prometaphase

2003 • 327 citations

Proteolytic cleavage of bacteriophage lambda repressor in induction.

1975 • 326 citations

Activation at M-phase of a protein kinase encoded by a starfish homologue of the cell cycle control gene cdc2+

1988 • 314 citations

Phosphorylation by Cdc28 Activates the Cdc20-Dependent Activity of the Anaphase-Promoting Complex

2000 • 290 citations

A single fission yeast mitotic cyclin B p34cdc2 kinase promotes both S-phase and mitosis in the absence of G1 cyclins.

1996 • 285 citations

Heightened sensitivity of a lattice of membrane receptors

1999 • 274 citations

Development of mice expressing a single D-type cyclin

2002 • 262 citations

Methylated ubiquitin inhibits cyclin degradation in clam embryo extracts.

1991 • 246 citations

Linkage of Replication to Start by the Cdk Inhibitor Sic1

1996 • 230 citations

Systematic identification of mitotic phosphoproteins

1997 • 225 citations

Synergistic action of Drosophila cyclins A and B during the G2-M transition.

1993 • 211 citations

A Predictive Scale for Evaluating Cyclin-dependent Kinase Substrates

1996 • 201 citations

A Response Regulator Model in a Simple Sensory System

1977 • 196 citations

Drosophila Cdk4 is required for normal growth and is dispensable for cell cycle progression

2000 • 190 citations

Radiosensitivity in ataxia-telangiectasia

1975 • 190 citations

Disassembly of in vitro formed lamin head-to-tail polymers by CDC2 kinase.

1991 • 188 citations

Protein phosphatase 2A regulates MPF activity and sister chromatid cohesion in budding yeast

1996 • 185 citations

The Drosophila cell cycle gene fizzy is required for normal degradation of cyclins A and B during mitosis and has homology to the CDC20 gene of Saccharomyces cerevisiae.

1995 • 180 citations

The Cyclin-Ubiquitin Ligase Activity of Cyclosome/APC Is Jointly Activated by Protein Kinases Cdk1-Cyclin B and Plk

2002 • 173 citations

Nuclear envelope breakdown in starfish oocytes proceeds by partial NPC disassembly followed by a rapidly spreading fenestration of nuclear membranes

2003 • 157 citations

The cyclin-dependent kinase inhibitor p40SIC1 imposes the requirement for Cln G1 cyclin function at Start.

1996 • 151 citations

Deregulated G₁-cyclin expression induces genomic instability by preventing efficient pre-RC formation

2002 • 150 citations

The cyclin family of budding yeast:abundant use of a good idea

1998 • 145 citations

Both cyclin A and cyclin E have S-phase promoting (SPF) activity in Xenopus egg extracts

1996 • 142 citations

A Bipartite Substrate Recognition Motif for Cyclin-dependent Kinases

2001 • 128 citations

Unmasking the S-Phase-Promoting Potential of Cyclin B1

2003 • 123 citations

Phosphorylation on protein kinase C sites inhibits nuclear import of lamin B2.

1993 • 120 citations

Cis-regulatory elements of the mitotic regulator, string/Cdc25

1999 • 118 citations

Evidence that a free-running oscillator drives G1 events in the budding yeast cell cycle

1999 • 113 citations

Rca1 Inhibits APC-Cdh1Fzr and Is Required to Prevent Cyclin Degradation in G2

2002 • 106 citations

A New Model for Nuclear Envelope Breakdown

2001 • 105 citations

Control of G1 in the developing Drosophila eye: rca1 regulates Cyclin A.

1997 • 104 citations

Mitogen‐activated protein kinases phosphorylate nuclear lamins and display sequence specificity overlapping that of mitotic protein kinase p34^cdc2

1992 • 104 citations

Specialization and Targeting of B-Type Cyclins

1999 • 100 citations

Cdc28 Activates Exit from Mitosis in Budding Yeast

2000 • 88 citations

Multi-site phosphorylation of pho4 by the cyclin-CDK pho80-pho85 is semi-processive with site preference

2001 • 77 citations

Regulation of the Appearance of Division Asynchrony and Microtubule-Dependent Chromosome Cycles in Xenopus laevis Embryos

1995 • 71 citations

Reciprocal Activation by Cyclin-Dependent Kinases 2 and 7 Is Directed by Substrate Specificity Determinants outside the T Loop

2001 • 70 citations

Growth regulation by oncogenes — new insights from model organisms

2001 • 68 citations

Sequential PKC- and Cdc2-mediated phosphorylation events elicit zebrafish nuclear envelope disassembly

1999 • 67 citations

Evolution of Eukaryotic Cell Cycle Regulation

2003 • 55 citations

Localization and Dynamics of Cdc2-Cyclin B during Meiotic Reinitiation in Starfish Oocytes

2003 • 33 citations

Cyclin D-Cdk4 Is Not a Master Regulator of Cell Multiplication in Drosophila Embryos

2002 • 30 citations

Coordinating Cell Cycle Events

1991 • 19 citations