Organization and evolution of variable region genes of the human immunoglobulin heavy chain

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

A rapid alkaline extraction procedure for screening recombinant plasmid DNA

1979 • 15,511 citations

Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mpl8 and pUC19 vectors

1985 • 15,222 citations

[2] New M13 vectors for cloning

1983 • 5,402 citations

Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing

1980 • 3,476 citations

Somatic generation of antibody diversity

1983 • 3,275 citations

A general method for isolation of high molecular weight DNA from eukaryotes

1976 • 2,827 citations

Rapid and efficient cosmid cloning

1981 • 1,897 citations

Dideoxy sequencing method using denatured plasmid templates

1986 • 1,537 citations

AN ANALYSIS OF THE SEQUENCES OF THE VARIABLE REGIONS OF BENCE JONES PROTEINS AND MYELOMA LIGHT CHAINS AND THEIR IMPLICATIONS FOR ANTIBODY COMPLEMENTARITY

1970 • 1,308 citations

Plasmid screening at high colony density

1980 • 1,100 citations

An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH

1980 • 872 citations

Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes

1980 • 803 citations

Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a γ2a variable region

1981 • 677 citations

Correct transcription of an immunoglobulin κ gene requires an upstream fragment containing conserved sequence elements

1984 • 669 citations

Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines

1984 • 644 citations

Cell-type specificity of iminunoglobulin gene expression is regulated by at least three DNA sequence elements

1985 • 588 citations

The immunoglobulin heavy chain variable region (Igh‐V) locus in the mouse. I. One hundred Igh‐V genes comprise seven families of homologous genes

1984 • 537 citations

Gene conversion: Some implications for immunoglobulin genes

1981 • 496 citations

Arrangement of human immunoglobulin heavy chain constant region genes implies evolutionary duplication of a segment containing γ, ε and α genes

1982 • 421 citations

Immunoglobulin Genes

1983 • 341 citations

A single rearrangement event generates most of the chicken immunoglobulin light chain diversity

1985 • 338 citations

Antibody diversity: Somatic hypermutation of rearranged VH genes

1981 • 334 citations

Isolation of β-globin-related genes from a human cosmid library

1981 • 277 citations

Cloning and complete nucleotide sequence of mouse immunoglobulin γ1 chain gene

1979 • 230 citations

Repetitive sequences in class-switch recombination regions of immunoglobulin heavy chain genes

1981 • 219 citations

Molecular basis of a mouse strain-specific anti-hapten response

1983 • 150 citations

An immunoglobulin promoter displays cell-type specificity independently of the enhancer

1985 • 144 citations

Diversity of germ-line immunoglobulin VH genes

1981 • 140 citations

Cloning of human immunoglobulin μ gene and comparison with mouse μ gene

1980 • 124 citations

Human Vκ immunoglobulin gene number: Implications for the origin of antibody diversity

1981 • 111 citations

Immunoglobulin genes of different subgroups are interdigitated within the V_Klocus

1984 • 110 citations

Organization and evolution of a gene cluster for human immunoglobulin variable regions of the kappa type

1984 • 107 citations

Origin of Immune Diversity: Genetic Variation and Selection

1985 • 99 citations

The nucleotide sequences of rearranged and germline immunoglobulin VH genes of a mouse myeloma MC101 and evolution of VH genes in mouse.

1982 • 76 citations

Functional and pseudogenes are similarly organized and may equally contribute to the extensive antibody diversity of the IgVHII family.

1985 • 72 citations

Somatic Mutations of Immunoglobulin Variable Genes Are Restricted to the Rearranged V Gene

1983 • 63 citations

<b>DELETION OF IMMUNOGLOBULIN HEAVY CHAIN GENES ACCOMPANIES THE CLASS SWITCH </b><b>REARRANGEMENT </b>

1980 • 53 citations

Conservation and divergence of immunoglobulin VH pseudogenes.

1983 • 33 citations