The multiple roles of monocyte subsets in steady state and inflammation

Monocyte and macrophage heterogeneity

2005 • 4,918 citations

Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties

2003 • 3,265 citations

Development of Monocytes, Macrophages, and Dendritic Cells

2010 • 2,823 citations

A clonogenic common myeloid progenitor that gives rise to all myeloid lineages

2000 • 2,528 citations

Analysis of Fractalkine Receptor CX₃CR1 Function by Targeted Deletion and Green Fluorescent Protein Reporter Gene Insertion

2000 • 2,356 citations

IDENTIFICATION OF A NOVEL CELL TYPE IN PERIPHERAL LYMPHOID ORGANS OF MICE

1973 • 2,286 citations

Transcriptional Profiling of the Human Monocyte-to-Macrophage Differentiation and Polarization: New Molecules and Patterns of Gene Expression

2006 • 2,214 citations

The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions

2007 • 2,057 citations

Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites

2009 • 2,032 citations

Monitoring of Blood Vessels and Tissues by a Population of Monocytes with Patrolling Behavior

2007 • 1,815 citations

Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis

2007 • 1,790 citations

Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2

2006 • 1,544 citations

Blood Monocytes: Development, Heterogeneity, and Relationship with Dendritic Cells

2009 • 1,514 citations

THE ORIGIN AND KINETICS OF MONONUCLEAR PHAGOCYTES

1968 • 1,492 citations

Immune and Inflammatory Mechanisms of Atherosclerosis

2009 • 1,372 citations

Gr-1+CD115+ Immature Myeloid Suppressor Cells Mediate the Development of Tumor-Induced T Regulatory Cells and T-Cell Anergy in Tumor-Bearing Host

2006 • 1,366 citations

Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques

2007 • 1,242 citations

Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell–suppressive activity

2008 • 1,185 citations

Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata

2007 • 1,183 citations

TNF/iNOS-Producing Dendritic Cells Mediate Innate Immune Defense against Bacterial Infection

2003 • 1,129 citations

Subpopulations of Mouse Blood Monocytes Differ in Maturation Stage and Inflammatory Response

2004 • 1,094 citations

Monocyte-Mediated Defense Against Microbial Pathogens

2008 • 1,061 citations

IDENTIFICATION OF A NOVEL CELL TYPE IN PERIPHERAL LYMPHOID ORGANS OF MICE

1974 • 1,041 citations

Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites

2007 • 1,029 citations

Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions

2007 • 1,007 citations

A Clonogenic Bone Marrow Progenitor Specific for Macrophages and Dendritic Cells

2005 • 990 citations

The CD14+ CD16+ blood monocytes: their role in infection and inflammation

2006 • 981 citations

Biology of Hematopoietic Stem Cells and Progenitors: Implications for Clinical Application

2003 • 974 citations

Identification and characterization of a novel monocyte subpopulation in human peripheral blood

1989 • 941 citations

In Vivo Analysis of Dendritic Cell Development and Homeostasis

2009 • 904 citations

The Proinflammatory CD14+CD16+DR++ Monocytes Are a Major Source of TNF

2002 • 845 citations

Monocytes in atherosclerosis: subsets and functions

2010 • 833 citations

Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells

2006 • 798 citations

Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo

2007 • 773 citations

The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse models

2008 • 756 citations

IDENTIFICATION OF A NOVEL CELL TYPE IN PERIPHERAL LYMPHOID ORGANS OF MICE

1974 • 694 citations

Langerhans cells arise from monocytes in vivo

2006 • 691 citations

Intestinal Lamina Propria Dendritic Cell Subsets Have Different Origin and Functions

2009 • 680 citations

Comparison of gene expression profiles between human and mouse monocyte subsets

2009 • 669 citations

Intraluminal crawling of neutrophils to emigration sites: a molecularly distinct process from adhesion in the recruitment cascade

2006 • 663 citations

Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow

2007 • 654 citations

Combined Inhibition of CCL2, CX3CR1, and CCR5 Abrogates Ly6C ^hi and Ly6C ^lo Monocytosis and Almost Abolishes Atherosclerosis in Hypercholesterolemic Mice

2008 • 623 citations

Monocytes give rise to mucosal, but not splenic, conventional dendritic cells

2006 • 591 citations

Fractalkine Preferentially Mediates Arrest and Migration of CD16+ Monocytes

2003 • 563 citations

Inflammatory Chemokine Transport and Presentation in HEV

2001 • 532 citations

Identification of a CD11b+/Gr-1+/CD31+ myeloid progenitor capable of activating or suppressing CD8+T cells

2000 • 516 citations

Rapid and Accurate Large-Scale Coestimation of Sequence Alignments and Phylogenetic Trees

2009 • 492 citations

Mechanisms and Consequences of Dendritic Cell Migration

2008 • 488 citations

Decreased Atherosclerotic Lesion Formation in CX3CR1/Apolipoprotein E Double Knockout Mice

2003 • 465 citations

Decreased atherosclerosis in CX3CR1–/– mice reveals a role for fractalkine in atherogenesis

2003 • 460 citations

CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival

2008 • 458 citations

Origin of dendritic cells in peripheral lymphoid organs of mice

2007 • 455 citations

Programmed death-1–induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection

2010 • 446 citations

Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands

2009 • 430 citations

TNF/iNOS-producing dendritic cells are the necessary evil of lethal influenza virus infection

2009 • 405 citations

Gr1+ Inflammatory Monocytes Are Required for Mucosal Resistance to the Pathogen Toxoplasma gondii

2008 • 401 citations

Macrophage Diversity and Polarization in Atherosclerosis

2009 • 400 citations

Differential chemokine receptor expression and function in human monocyte subpopulations

2000 • 389 citations

CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation

2009 • 388 citations

The novel subset of CD14⁺/CD16⁺ blood monocytes exhibits features of tissue macrophages

1993 • 383 citations

Dendritic Cells Rapidly Recruited into Epithelial Tissues via CCR6/CCL20 Are Responsible for CD8+ T Cell Crosspriming In Vivo

2006 • 366 citations

The CD16+ (FcγRIII+) Subset of Human Monocytes Preferentially Becomes Migratory Dendritic Cells in a Model Tissue Setting

2002 • 360 citations

Impact of Heterogeneity of Human Peripheral Blood Monocyte Subsets on Myocardial Salvage in Patients With Primary Acute Myocardial Infarction

2009 • 359 citations

Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC network

2009 • 356 citations

Monocyte accumulation in mouse atherogenesis is progressive and proportional to extent of disease

2006 • 352 citations

Heterogeneity of human peripheral blood monocyte subsets

2001 • 352 citations

Monocyte subpopulations and their differentiation patterns during infection

2007 • 337 citations

Bone Marrow Ly6Chigh Monocytes Are Selectively Recruited to Injured Kidney and Differentiate into Functionally Distinct Populations

2009 • 316 citations

Distinct Differentiation Potential of Blood Monocyte Subsets in the Lung

2007 • 315 citations

Differential cytokine expression in human blood monocyte subpopulations: a polymerase chain reaction analysis

1996 • 311 citations

Peripheral Blood CD14^high CD16⁺ Monocytes are Main Producers of IL‐10

2008 • 284 citations

Recruitment of Gr-1+ monocytes is essential for control of acute toxoplasmosis

2005 • 274 citations

Differentiation and function of mouse monocyte‐derived dendritic cells in steady state and inflammation

2010 • 240 citations

Additive Roles for MCP-1 and MCP-3 in CCR2-Mediated Recruitment of Inflammatory Monocytes during Listeria monocytogenes Infection

2008 • 237 citations

Fractalkine Deficiency Markedly Reduces Macrophage Accumulation and Atherosclerotic Lesion Formation in CCR2 ^−/− Mice

2007 • 225 citations

Blood Monocyte Subsets Differentially Give Rise to CD103+ and CD103− Pulmonary Dendritic Cell Populations

2008 • 224 citations

Functional Role of CD11c ⁺ Monocytes in Atherogenesis Associated With Hypercholesterolemia

2009 • 219 citations

Critical Role of Monocyte Chemoattractant Protein-1 Receptor CCR2 on Monocytes in Hypertension-Induced Vascular Inflammation and Remodeling

2004 • 214 citations

Sequential MyD88-Independent and -Dependent Activation of Innate Immune Responses to Intracellular Bacterial Infection

2003 • 207 citations

Regulation of the Migration and Survival of Monocyte Subsets by Chemokine Receptors and Its Relevance to Atherosclerosis

2009 • 206 citations

P-Selectin Glycoprotein Ligand-1 Is Highly Expressed on Ly-6C ^hi Monocytes and a Major Determinant for Ly-6C ^hi Monocyte Recruitment to Sites of Atherosclerosis in Mice

2008 • 166 citations

CD16+ and CD16− human blood monocyte subsets differentiate in vitro to dendritic cells with different abilities to stimulate CD4+ T cells

2001 • 156 citations

The Ly-6Chigh Monocyte Subpopulation Transports Listeria monocytogenes into the Brain during Systemic Infection of Mice

2004 • 154 citations

Phenotypical and functional characterization of Fey receptor I (CD64)‐negative monocytes, a minor human monocyte subpopulation with high accessory and antiviral activity

1993 • 152 citations

Identification of a novel dendritic cell-like subset of CD64(+) / CD16(+) blood monocytes.

2001 • 146 citations

MyD88-Dependent Activation of B220−CD11b+LY-6C+ Dendritic Cells during Brucella melitensis Infection

2007 • 138 citations

Heterogeneous In Vivo Behavior of Monocyte Subsets in Atherosclerosis

2009 • 128 citations

Identification of a novel dendritic cell-like subset of CD64+ / CD16+ blood monocytes

2001 • 121 citations

Functions of human monocyte and lymphocyte subsets obtained by countercurrent centrifugal elutriation: differing functional capacities of human monocyte subsets.

1981 • 121 citations

Isolation of functionally different human monocytes by counterflow centrifugation elutriation

1982 • 111 citations

The Monoclonal Antimonocyte Antibody My4 Stains B Lymphocytes and Two Distinct Monocyte Subsets in Human Peripheral Blood

1988 • 109 citations

Memory CD8+ T cells mediate antibacterial immunity via CCL3 activation of TNF/ROI+ phagocytes

2007 • 100 citations

Isolation and functional characteristics of FcR+ and FcR- human monocyte subsets.

1984 • 79 citations

Selective expansion of CD16highCCR2– subpopulation of circulating monocytes with preferential production of haem oxygenase (HO)-1 in response to acute inflammation

2005 • 74 citations

Expansion of CD14+CD16+ monocytes in critically ill cardiac surgery patients.

1998 • 71 citations

Diversity of Denizens of the Atherosclerotic Plaque

2008 • 69 citations

The CD14+CD16+ monocytes in erysipelas are expanded and show reduced cytokine production

2002 • 69 citations

Human MO Subsets as Defined by Expression of CD64 and CD 16 Differ in Phagocytic Activity and Generation of Oxygen Intermediates

2000 • 61 citations

THE RELATION OF MONOCYTES AND CLASMATOCYTES TO EARLY INFECTION IN RABBITS WITH BOVINE TUBERCLE BACILLI

1927 • 57 citations

Monocyte Subset Dynamics in Human Atherosclerosis Can Be Profiled with Magnetic Nano-Sensors

2009 • 56 citations

THERMAL INJURY ELEVATES THE INFLAMMATORY MONOCYTE SUBPOPULATION IN MULTIPLE COMPARTMENTS

2007 • 53 citations

Characterization of a human blood monocyte subset with low peroxidase activity.

1983 • 44 citations

Differential Ability of Human Blood Monocyte Subsets to Release Various Cytokines

1985 • 43 citations

Active Leukocyte Crawling in Microvessels Assessed by Digital Time-Lapse Intravital Microscopy

2006 • 30 citations

Books Received

2009 • 27 citations

Immunological heterogeneity of human monocyte subsets prepared by counterflow centrifugation elutriation.

1986 • 24 citations

Differential interleukin-1 elaboration by density-defined human monocyte subpopulations

1985 • 24 citations

The regulation of polyclonal immunoglobulin synthesis by FcR+ and FcR− monocyte subsets

1985 • 18 citations

Human monocyte functional heterogeneity: monocyte fractionation by discontinuous albumin gradient centrifugation.

1983 • 17 citations

Fcγ receptor I (CD64)-negative human monocytes are potent accessory cells in viral antigen-induced T cell activation and exhibit high IFN-α-producing capacity

1996 • 15 citations

Subfractionation of human blood monocyte subsets with Percoll.

1984 • 15 citations

An Fcγ receptor I (CD64)‐negative subpopulation of human peripheral blood monocytes is resistant to killing by antigen‐activated CD4‐positive cytotoxic T cells

1997 • 14 citations