CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival

Inflammation in atherosclerosis

2002 • 7,873 citations

Monocyte and macrophage heterogeneity

2005 • 4,918 citations

Chemokines

2000 • 3,773 citations

Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties

2003 • 3,265 citations

Analysis of Fractalkine Receptor CX₃CR1 Function by Targeted Deletion and Green Fluorescent Protein Reporter Gene Insertion

2000 • 2,356 citations

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

1992 • 2,216 citations

The immune response in atherosclerosis: a double-edged sword

2006 • 2,116 citations

The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions

2007 • 2,057 citations

A new class of membrane-bound chemokine with a CX3C motif

1997 • 1,964 citations

Monitoring of Blood Vessels and Tissues by a Population of Monocytes with Patrolling Behavior

2007 • 1,815 citations

Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2

2006 • 1,544 citations

CX ₃ CR1-Mediated Dendritic Cell Access to the Intestinal Lumen and Bacterial Clearance

2005 • 1,534 citations

THE ORIGIN AND KINETICS OF MONONUCLEAR PHAGOCYTES

1968 • 1,492 citations

Identification and Molecular Characterization of Fractalkine Receptor CX3CR1, which Mediates Both Leukocyte Migration and Adhesion

1997 • 1,406 citations

Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques

2007 • 1,242 citations

Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata

2007 • 1,183 citations

MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment

2007 • 1,171 citations

Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia

1998 • 1,118 citations

The CD14+ CD16+ blood monocytes: their role in infection and inflammation

2006 • 981 citations

Differentiation of Phagocytic Monocytes into Lymph Node Dendritic Cells In Vivo

1999 • 904 citations

The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion

2003 • 686 citations

Fractalkine and CX3CR1 Mediate a Novel Mechanism of Leukocyte Capture, Firm Adhesion, and Activation under Physiologic Flow

1998 • 679 citations

Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation

1997 • 656 citations

Consequences and Therapeutic Implications of Macrophage Apoptosis in Atherosclerosis

2005 • 623 citations

Tumor Necrosis Factor-α-converting Enzyme (ADAM17) Mediates the Cleavage and Shedding of Fractalkine (CX3CL1)

2001 • 623 citations

Monocytes give rise to mucosal, but not splenic, conventional dendritic cells

2006 • 591 citations

Fractalkine Preferentially Mediates Arrest and Migration of CD16+ Monocytes

2003 • 563 citations

Inflammatory Chemokine Transport and Presentation in HEV

2001 • 532 citations

Prevention of Atherosclerosis in Apolipoprotein E-Deficient Mice by Bone Marrow Transplantation

1995 • 467 citations

Decreased Atherosclerotic Lesion Formation in CX3CR1/Apolipoprotein E Double Knockout Mice

2003 • 465 citations

Decreased atherosclerosis in CX3CR1–/– mice reveals a role for fractalkine in atherogenesis

2003 • 460 citations

CXCR4 Is a Major Chemokine Receptor on Glioma Cells and Mediates Their Survival

2002 • 369 citations

Polymorphism in the fractalkine receptor CX3CR1 as a genetic risk factor for coronary artery disease

2001 • 348 citations

Monocyte recruitment and foam cell formation in atherosclerosis

2005 • 347 citations

Localization of fractalkine and CX₃CR1 mRNAs in rat brain: does fractalkine play a role in signaling from neuron to microglia?

1998 • 334 citations

Distinct Differentiation Potential of Blood Monocyte Subsets in the Lung

2007 • 315 citations

Enforced Expression of Bcl-2 in Monocytes Rescues Macrophages and Partially Reverses Osteopetrosis in op/op Mice

1997 • 292 citations

bcl-2 inhibits apoptosis of neutrophils but not their engulfment by macrophages.

1994 • 288 citations

CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infection

2005 • 288 citations

Identification of CX 3CR1

1998 • 282 citations

Ccr5 But Not Ccr1 Deficiency Reduces Development of Diet-Induced Atherosclerosis in Mice

2006 • 273 citations

Pivotal Role of CXCR3 in Melanoma Cell Metastasis to Lymph Nodes

2004 • 266 citations

Association Between Polymorphism in the Chemokine Receptor CX3CR1 and Coronary Vascular Endothelial Dysfunction and Atherosclerosis

2001 • 257 citations

Fractalkine Is an Epithelial and Endothelial Cell-Derived Chemoattractant for Intraepithelial Lymphocytes in the Small Intestinal Mucosa

2000 • 252 citations

Fractalkine Deficiency Markedly Reduces Macrophage Accumulation and Atherosclerotic Lesion Formation in CCR2 ^−/− Mice

2007 • 225 citations

Blood Monocyte Subsets Differentially Give Rise to CD103+ and CD103− Pulmonary Dendritic Cell Populations

2008 • 224 citations

Origin and Turnover of Monocytes and Macrophages

1989 • 200 citations

The Chemokine Fractalkine Inhibits Fas-Mediated Cell Death of Brain Microglia

2000 • 190 citations

Major reduction of atherosclerosis in fractalkine (CX3CL1)-deficient mice is at the brachiocephalic artery, not the aortic root

2004 • 188 citations

Chemokines in tumor progression and metastasis

2005 • 186 citations

Linked Chromosome 16q13 Chemokines, Macrophage-Derived Chemokine, Fractalkine, and Thymus- and Activation-Regulated Chemokine, Are Expressed in Human Atherosclerotic Lesions

2001 • 182 citations

Transmembrane chemokines: Versatile ‘special agents’ in vascular inflammation

2007 • 176 citations

Fractalkine, a CX3C chemokine, is expressed by dendritic cells and is up-regulated upon dendritic cell maturation

1999 • 174 citations

The Transmembrane Form of the CX3CL1 Chemokine Fractalkine Is Expressed Predominantly by Epithelial Cells in Vivo

2001 • 168 citations

CX ₃ CR1 Deficiency Impairs Dendritic Cell Accumulation in Arterial Intima and Reduces Atherosclerotic Burden

2007 • 156 citations

Generation and Analysis of Mice Lacking the Chemokine Fractalkine

2001 • 155 citations

Fractalkine (CX3CL1) stimulated by nuclear factor kappaB (NF-kappaB)-dependent inflammatory signals induces aortic smooth muscle cell proliferation through an autocrine pathway

2003 • 154 citations

Fractalkine Is Expressed by Smooth Muscle Cells in Response to IFN-γ and TNF-α and Is Modulated by Metalloproteinase Activity

2002 • 146 citations

CD73/Ecto-5′-Nucleotidase Protects Against Vascular Inflammation and Neointima Formation

2006 • 139 citations

OBSERVATIONS ON HUMAN MONOCYTE KINETICS AFTER PULSE LABELING

1972 • 135 citations

Neointimal Smooth Muscle Cells Display a Proinflammatory Phenotype Resulting in Increased Leukocyte Recruitment Mediated by P-Selectin and Chemokines

2004 • 118 citations

Fractalkine-mediated signals regulate cell-survival and immune-modulatory responses in intestinal epithelial cells

2002 • 100 citations

Distinctive Expression of Chemokines and Transforming Growth Factor-β Signaling in Human Arterial Endothelium during Atherosclerosis

2007 • 64 citations

Oxysterols in cap and core of human advanced atherosclerotic lesions

1999 • 58 citations

Proline 326 in the C Terminus of Murine CX3CR1 Prevents G-Protein and Phosphatidylinositol 3-Kinase-Dependent Stimulation of Akt and Extracellular Signal-Regulated Kinase in Chinese Hamster Ovary Cells

2005 • 29 citations

Death‐signaling pathways in human myeloid cells by oxLDL and its cytotoxic components 7β‐hydroxycholesterol and cholesterol‐5β,6β‐epoxide

2007 • 14 citations