The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse models

Isolation of Putative Progenitor Endothelial Cells for Angiogenesis

1997 • 8,673 citations

Inflammation, Atherosclerosis, and Coronary Artery Disease

2005 • 8,367 citations

Obesity induces a phenotypic switch in adipose tissue macrophage polarization

2007 • 4,269 citations

Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties

2003 • 3,265 citations

Endothelial Progenitor Cells

2004 • 2,347 citations

Expression of VEGFR-2 and AC133 by circulating human CD34+ cells identifies a population of functional endothelial precursors

2000 • 2,286 citations

Transcriptional Profiling of the Human Monocyte-to-Macrophage Differentiation and Polarization: New Molecules and Patterns of Gene Expression

2006 • 2,214 citations

The immune response in atherosclerosis: a double-edged sword

2006 • 2,116 citations

The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions

2007 • 2,057 citations

Monitoring of Blood Vessels and Tissues by a Population of Monocytes with Patrolling Behavior

2007 • 1,815 citations

Matrix metalloproteinases in vascular remodeling and atherogenesis: the good, the bad, and the ugly.

2002 • 1,781 citations

Plasmacytoid dendritic cells in immunity

2004 • 1,645 citations

Matrix Metalloproteinases in Vascular Remodeling and Atherogenesis

2002 • 1,460 citations

Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals

2006 • 1,453 citations

Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques

2007 • 1,242 citations

Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata

2007 • 1,183 citations

Steady-state and inflammatory dendritic-cell development

2006 • 1,172 citations

MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment

2007 • 1,171 citations

Hematopoietic stem cells differentiate into vascular cells that participate in the pathogenesis of atherosclerosis

2002 • 1,170 citations

Association Between Myeloperoxidase Levels and Risk of Coronary Artery Disease

2001 • 920 citations

Protective Role of Interleukin-10 in Atherosclerosis

1999 • 805 citations

Human atherosclerosis. II. Immunocytochemical analysis of the cellular composition of human atherosclerotic lesions.

1986 • 676 citations

Neutrophil Infiltration of Culprit Lesions in Acute Coronary Syndromes

2002 • 651 citations

Alloantigen-presenting plasmacytoid dendritic cells mediate tolerance to vascularized grafts

2006 • 625 citations

Consequences and Therapeutic Implications of Macrophage Apoptosis in Atherosclerosis

2005 • 623 citations

Combined Inhibition of CCL2, CX3CR1, and CCR5 Abrogates Ly6C ^hi and Ly6C ^lo Monocytosis and Almost Abolishes Atherosclerosis in Hypercholesterolemic Mice

2008 • 623 citations

Infiltrates of Activated Mast Cells at the Site of Coronary Atheromatous Erosion or Rupture in Myocardial Infarction

1995 • 620 citations

Repetitive Injections of Dendritic Cells Matured with Tumor Necrosis Factor α Induce Antigen-specific Protection of Mice from Autoimmunity

2001 • 560 citations

Transfer of CD4 ⁺ T Cells Aggravates Atherosclerosis in Immunodeficient Apolipoprotein E Knockout Mice

2000 • 546 citations

Human CD34+AC133+VEGFR-2+ cells are not endothelial progenitor cells but distinct, primitive hematopoietic progenitors

2007 • 526 citations

Protective immunity against atherosclerosis carried by B cells of hypercholesterolemic mice

2002 • 523 citations

Smooth Muscle Progenitor Cells in Human Blood

2002 • 504 citations

Emigration of monocyte-derived cells from atherosclerotic lesions characterizes regressive, but not progressive, plaques

2004 • 501 citations

Endothelial progenitor cells: characterization, pathophysiology, and possible clinical relevance

2004 • 477 citations

Vascular wall resident progenitor cells: a source for postnatal vasculogenesis

2006 • 468 citations

Mesenchymal stem cells: a new strategy for immunosuppression?

2007 • 450 citations

Lymphocyte recruitment into the aortic wall before and during development of atherosclerosis is partially L-selectin dependent

2006 • 432 citations

Hypercholesterolemia is associated with a T helper (Th) 1/Th2 switch of the autoimmune response in atherosclerotic apo E-knockout mice.

1998 • 421 citations

Mast cell tryptases and chymases in inflammation and host defense

2007 • 420 citations

Human abdominal aortic aneurysms. Immunophenotypic analysis suggesting an immune-mediated response.

1990 • 412 citations

Mast cells promote atherosclerosis by releasing proinflammatory cytokines

2007 • 412 citations

Protective Role of CXC Receptor 4/CXC Ligand 12 Unveils the Importance of Neutrophils in Atherosclerosis

2007 • 405 citations

Hypochlorous Acid, a Macrophage Product, Induces Endothelial Apoptosis and Tissue Factor Expression

2004 • 400 citations

Neutrophil secretion products pave the way for inflammatory monocytes

2008 • 397 citations

Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth

2008 • 394 citations

Death of Smooth Muscle Cells and Expression of Mediators of Apoptosis by T Lymphocytes in Human Abdominal Aortic Aneurysms

1999 • 394 citations

Differential chemokine receptor expression and function in human monocyte subpopulations

2000 • 389 citations

Interferon-γ elicits arteriosclerosis in the absence of leukocytes

2000 • 375 citations

Chemokines in Atherosclerosis

2008 • 374 citations

SDF-1α/CXCR4 Axis Is Instrumental in Neointimal Hyperplasia and Recruitment of Smooth Muscle Progenitor Cells

2005 • 359 citations

Monocyte accumulation in mouse atherogenesis is progressive and proportional to extent of disease

2006 • 352 citations

T and B lymphocytes play a minor role in atherosclerotic plaque formation in the apolipoprotein E-deficient mouse

1997 • 346 citations

Smooth muscle cells in human coronary atherosclerosis can originate from cells administered at marrow transplantation

2003 • 343 citations

Endothelial Outgrowth Cells Are Not Derived From CD133 ⁺ Cells or CD45 ⁺ Hematopoietic Precursors

2007 • 340 citations

Expression of Neutrophil Gelatinase–Associated Lipocalin in Atherosclerosis and Myocardial Infarction

2005 • 339 citations

T-bet deficiency reduces atherosclerosis and alters plaque antigen-specific immune responses

2005 • 335 citations

Role of macrophage colony-stimulating factor in atherosclerosis: studies of osteopetrotic mice.

1997 • 330 citations

Allograft Vasculopathy Versus Atherosclerosis

2006 • 321 citations

Low-grade chronic inflammation in regions of the normal mouse arterial intima predisposed to atherosclerosis

2006 • 318 citations

Tie2-expressing monocytes: regulation of tumor angiogenesis and therapeutic implications

2007 • 277 citations

Ccr5 But Not Ccr1 Deficiency Reduces Development of Diet-Induced Atherosclerosis in Mice

2006 • 273 citations

Perivascular Mast Cells Promote Atherogenesis and Induce Plaque Destabilization in Apolipoprotein E–Deficient Mice

2007 • 273 citations

Activation of Matrix-Degrading Metalloproteinases by Mast Cell Proteases in Atherosclerotic Plaques

1998 • 269 citations

Emergence of dendritic cells in rupture-prone regions of vulnerable carotid plaques

2004 • 259 citations

CD14+CD34 ^low Cells With Stem Cell Phenotypic and Functional Features Are the Major Source of Circulating Endothelial Progenitors

2005 • 253 citations

Monocyte/Macrophage Suppression in CD11b Diphtheria Toxin Receptor Transgenic Mice Differentially Affects Atherogenesis and Established Plaques

2007 • 252 citations

Dyslipidemia Associated with Atherosclerotic Disease Systemically Alters Dendritic Cell Mobilization

2004 • 252 citations

Neutrophil Depletion Inhibits Experimental Abdominal Aortic Aneurysm Formation

2005 • 248 citations

Lactadherin Deficiency Leads to Apoptotic Cell Accumulation and Accelerated Atherosclerosis in Mice

2007 • 246 citations

Importance of CXC Chemokine Receptor 2 in the Homing of Human Peripheral Blood Endothelial Progenitor Cells to Sites of Arterial Injury

2007 • 244 citations

Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in mice

2007 • 243 citations

Overexpression of Eotaxin and the CCR3 Receptor in Human Atherosclerosis

2000 • 243 citations

Influence of Cardiovascular Risk Factors on Endothelial Progenitor Cells

2005 • 237 citations

Pathogen-Sensing Plasmacytoid Dendritic Cells Stimulate Cytotoxic T-Cell Function in the Atherosclerotic Plaque Through Interferon-α

2006 • 233 citations

Fractalkine Deficiency Markedly Reduces Macrophage Accumulation and Atherosclerotic Lesion Formation in CCR2 ^−/− Mice

2007 • 225 citations

Monocyte chemotactic protein 1 is a potent activator of human basophils.

1992 • 218 citations

The Number of Endothelial Progenitor Cell Colonies in the Blood Is Increased in Patients With Angiographically Significant Coronary Artery Disease

2006 • 215 citations

The Lamina Adventitia Is the Major Site of Immune Cell Accumulation in Standard Chow-Fed Apolipoprotein E–Deficient Mice

2005 • 209 citations

Transfer of Endothelial Progenitor and Bone Marrow Cells Influences Atherosclerotic Plaque Size and Composition in Apolipoprotein E Knockout Mice

2005 • 200 citations

Accumulation of Myeloperoxidase-Positive Neutrophils in Atherosclerotic Lesions in LDLR ^−/− Mice

2007 • 194 citations

Dendritic cells in atherosclerosis: current status of the problem and clinical relevance

2005 • 188 citations

Network of Vascular-Associated Dendritic Cells in Intima of Healthy Young Individuals

2001 • 182 citations

DC ablation in mice: promises, pitfalls, and challenges

2007 • 171 citations

MAST CELL DISTRIBUTION, ACTIVATION, AND PHENOTYPE IN ATHEROSCLEROTIC LESIONS OF HUMAN CAROTID ARTERIES

1997 • 168 citations

Genetically Programmed Biases in Th1 and Th2 Immune Responses Modulate Atherogenesis

2008 • 166 citations

Chemokines in Atherosclerosis

2014 • 165 citations

Rapid Endothelial Turnover in Atherosclerosis-Prone Areas Coincides With Stem Cell Repair in Apolipoprotein E–Deficient Mice

2008 • 160 citations

Role of macrophages in atherosclerosis. Sequential observations of cholesterol-induced rabbit aortic lesion by the immunoperoxidase technique using monoclonal antimacrophage antibody.

1985 • 157 citations

CX ₃ CR1 Deficiency Impairs Dendritic Cell Accumulation in Arterial Intima and Reduces Atherosclerotic Burden

2007 • 156 citations

Endothelial Progenitor Cells, Cardiovascular Risk Factors, Cytokine Levels and Atherosclerosis – Results from a Large Population-Based Study

2007 • 151 citations

Reduced numbers of circulating endothelial progenitor cells in patients with coronary artery disease associated with long-term statin treatment

2006 • 149 citations

Detection of B Cells and Proinflammatory Cytokines in Atherosclerotic Plaques of Hypercholesterolaemic Apolipoprotein E Knockout Mice

1999 • 139 citations

Synergistic Proinflammatory Effects of the Antiviral Cytokine Interferon-α and Toll-Like Receptor 4 Ligands in the Atherosclerotic Plaque

2007 • 133 citations

Association between leukocyte count and the presence and extent of coronary atherosclerosis as determined by coronary arteriography

1984 • 133 citations

Mast cells: multipotent local effector cells in atherothrombosis

2007 • 130 citations

Smooth Muscle Cells Healing Atherosclerotic Plaque Disruptions Are of Local, Not Blood, Origin in Apolipoprotein E Knockout Mice

2007 • 129 citations

Dendritic cell–endothelial cell cross-talk in angiogenesis

2007 • 127 citations

Immunomodulation of Atherosclerosis

2004 • 122 citations

Decrease in Circulating Myeloid Dendritic Cell Precursors in Coronary Artery Disease

2006 • 113 citations

Effects of oxidised low density lipoprotein on dendritic cells: a possible immunoregulatory component of the atherogenic micro-environment?

2002 • 110 citations

Thematic review series: The Immune System and Atherogenesis. The unusual suspects:an overview ofthe minor leukocyte populations in atherosclerosis

2005 • 107 citations

Dyslipidemia inhibits Toll-like receptor–induced activation of CD8α-negative dendritic cells and protective Th1 type immunity

2007 • 103 citations

Granulocyte Colony-Stimulating Factor and Granulocyte Macrophage Colony-Stimulating Factor Exacerbate Atherosclerosis in Apolipoprotein E–Deficient Mice

2007 • 100 citations

Regulatory T‐cell immunity and its relevance to atherosclerosis

2008 • 97 citations

Band neutrophil count and the presence and severity of coronary atherosclerosis

1996 • 92 citations

Characterization of smooth muscle-like cells in circulating human peripheral blood

2005 • 92 citations

Vessel Wall–Embedded Dendritic Cells Induce T-Cell Autoreactivity and Initiate Vascular Inflammation

2008 • 89 citations

Mast Cells and Susceptibility to Experimental Atherosclerosis

1953 • 88 citations

Pathways of murine mast cell development and trafficking: tracking the roots and routes of the mast cell

2007 • 88 citations

Role of human smooth muscle cell progenitors in atherosclerotic plaque development and composition

2007 • 87 citations

Granulocyte Macrophage Colony-Stimulating Factor Regulates Dendritic Cell Content of Atherosclerotic Lesions

2006 • 84 citations

Multiple complex stenoses, high neutrophil count and C-reactive protein levels in patients with chronic stable angina

2004 • 82 citations

Immunohistochemical characterization of inflammatory cells associated with advanced atherosclerosis

1990 • 78 citations

Distribution of Inflammatory Cells in Adventitia Changed with Advancing Atherosclerosis of Human Coronary Artery

2007 • 76 citations

Effects of clodronate (dichloromethylene bisphosphonate) on the development of experimental atherosclerosis in rabbits.

1994 • 75 citations

Interleukin-10 (IL-10) Augments Allograft Arterial Disease

1999 • 74 citations

Stromal Cell–Derived Factor-1 and CXCR4 Interaction Is Critical for Development of Transplant Arteriosclerosis

2004 • 63 citations

Mast cell proteases: Physiological tools to study functional significance of high density lipoproteins in the initiation of reverse cholesterol transport

2006 • 51 citations

Myeloperoxidase genetic polymorphisms modulate human neutrophil enzyme activity: Genetic determinants for atherosclerosis?

2005 • 41 citations

Expression of α2-macroglobulin, neutrophil elastase, and interleukin-1α differs in early-stage and late-stage atherosclerotic lesions in the arteries of the circle of Willis

2006 • 28 citations

Unrestricted usage of immunoglobulin heavy chain genes in B cells infiltrating the wall of atherosclerotic abdominal aortic aneurysms

1997 • 26 citations

Structure-based optimization of PKCθ inhibitors

2007 • 10 citations

The role of stem cells in vein graft remodelling

2007 • 5 citations