Development of Monocytes, Macrophages, and Dendritic Cells

Dendritic cells and the control of immunity

1998 • 14,345 citations

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

1994 • 5,204 citations

Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties

2003 • 3,265 citations

Macrophage activation and polarization

2007 • 2,948 citations

Alternative Activation of Macrophages: An Immunologic Functional Perspective

2008 • 2,611 citations

Dendritic Cells

2001 • 2,164 citations

The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions

2007 • 2,057 citations

Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites

2009 • 2,032 citations

Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation.

1992 • 1,849 citations

Monitoring of Blood Vessels and Tissues by a Population of Monocytes with Patrolling Behavior

2007 • 1,815 citations

Batf3 Deficiency Reveals a Critical Role for CD8α ⁺ Dendritic Cells in Cytotoxic T Cell Immunity

2008 • 1,781 citations

MicroRNA-155 is induced during the macrophage inflammatory response

2007 • 1,765 citations

Plasmacytoid dendritic cells in immunity

2004 • 1,645 citations

Blood Monocytes: Development, Heterogeneity, and Relationship with Dendritic Cells

2009 • 1,514 citations

THE ORIGIN AND KINETICS OF MONONUCLEAR PHAGOCYTES

1968 • 1,492 citations

Local self-renewal can sustain CNS microglia maintenance and function throughout adult life

2007 • 1,474 citations

Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors

2005 • 1,266 citations

Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell–suppressive activity

2008 • 1,185 citations

Pattern Recognition Receptors

2002 • 1,139 citations

VEGF-Induced Adult Neovascularization: Recruitment, Retention, and Role of Accessory Cells

2006 • 1,122 citations

Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects

2002 • 1,061 citations

Monocyte-Mediated Defense Against Microbial Pathogens

2008 • 1,061 citations

IDENTIFICATION OF A NOVEL CELL TYPE IN PERIPHERAL LYMPHOID ORGANS OF MICE

1974 • 1,041 citations

Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions

2007 • 1,007 citations

A Clonogenic Bone Marrow Progenitor Specific for Macrophages and Dendritic Cells

2005 • 990 citations

Genetic Dissection of Immunity to Mycobacteria: The Human Model

2002 • 960 citations

Langerhans cells renew in the skin throughout life under steady-state conditions

2002 • 946 citations

Physiological Migration of Hematopoietic Stem and Progenitor Cells

2001 • 938 citations

In Vivo Analysis of Dendritic Cell Development and Homeostasis

2009 • 904 citations

Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells

2000 • 863 citations

Origin of the Lamina Propria Dendritic Cell Network

2009 • 810 citations

Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo

2007 • 773 citations

Discovery of a Cytokine and Its Receptor by Functional Screening of the Extracellular Proteome

2008 • 744 citations

Infiltrating Blood-Derived Macrophages Are Vital Cells Playing an Anti-inflammatory Role in Recovery from Spinal Cord Injury in Mice

2009 • 719 citations

IDENTIFICATION OF A NOVEL CELL TYPE IN PERIPHERAL LYMPHOID ORGANS OF MICE

1974 • 694 citations

Immunosurveillance by Hematopoietic Progenitor Cells Trafficking through Blood, Lymph, and Peripheral Tissues

2007 • 681 citations

Intestinal Lamina Propria Dendritic Cell Subsets Have Different Origin and Functions

2009 • 680 citations

Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder

2008 • 669 citations

Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions

2009 • 659 citations

Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow

2007 • 654 citations

A macrophage colony-stimulating factor receptor–green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse

2003 • 634 citations

Multilineage Transcriptional Priming and Determination of Alternate Hematopoietic Cell Fates

2006 • 622 citations

The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues

2008 • 612 citations

Transcription Factor E2-2 Is an Essential and Specific Regulator of Plasmacytoid Dendritic Cell Development

2008 • 610 citations

Intrasplenic steady-state dendritic cell precursors that are distinct from monocytes

2006 • 600 citations

Monocytes give rise to mucosal, but not splenic, conventional dendritic cells

2006 • 591 citations

Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans

2008 • 588 citations

Molecular Cloning of a Complementary DNA Encoding Human Macrophage-Specific Colony-Stimulating Factor (CSF-1)

1985 • 542 citations

Role of colony stimulating factor-1 in the establishment and regulation of tissue macrophages during postnatal development of the mouse

1994 • 538 citations

Transforming Growth Factor β1, in the Presence of Granulocyte/Macrophage Colony-stimulating Factor and Interleukin 4, Induces Differentiation of Human Peripheral Blood Monocytes into Dendritic Langerhans Cells

1998 • 507 citations

Myeloid or Lymphoid Promiscuity as a Critical Step in Hematopoietic Lineage Commitment

2002 • 428 citations

Gr1+ Inflammatory Monocytes Are Required for Mucosal Resistance to the Pathogen Toxoplasma gondii

2008 • 401 citations

CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation

2009 • 388 citations

The Early Progenitors of Mouse Dendritic Cells and Plasmacytoid Predendritic Cells Are within the Bone Marrow Hemopoietic Precursors Expressing Flt3

2003 • 383 citations

Dendritic cell homeostasis

2009 • 383 citations

Blood monocytes: distinct subsets, how they relate to dendritic cells, and their possible roles in the regulation of T‐cell responses

2008 • 381 citations

Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC network

2009 • 356 citations

Intrinsic Lymphotoxin-β Receptor Requirement for Homeostasis of Lymphoid Tissue Dendritic Cells

2005 • 312 citations

The Kruppel-like factor KLF4 is a critical regulator of monocyte differentiation

2007 • 293 citations

Recruitment of Gr-1+ monocytes is essential for control of acute toxoplasmosis

2005 • 274 citations

Plasmacytoid Dendritic Cells Activate Lymphoid-Specific Genetic Programs Irrespective of Their Cellular Origin

2004 • 247 citations

The hematopoietic stem cell and its niche: a comparative view

2007 • 223 citations

The Lymphoid Past of Mouse Plasmacytoid Cells and Thymic Dendritic Cells

2003 • 210 citations

Human-Hemato-Lymphoid-System Mice: Opportunities and Challenges

2007 • 207 citations

Kruppel-Like Factor 4 Is Essential for Inflammatory Monocyte Differentiation In Vivo

2008 • 200 citations

Thymus-homing peripheral dendritic cells constitute two of the three major subsets of dendritic cells in the steady-state thymus

2009 • 194 citations

A transcription factor party during blood cell differentiation

1998 • 165 citations

Laser capture microdissection analysis of gene expression in macrophages from atherosclerotic lesions of apolipoprotein E-deficient mice

2002 • 165 citations

Heterogeneity of thymic dendritic cells

2005 • 162 citations

Balance of MafB and PU.1 specifies alternative macrophage or dendritic cell fate

2004 • 161 citations

MafB Restricts M-CSF-Dependent Myeloid Commitment Divisions of Hematopoietic Stem Cells

2009 • 159 citations

Circulating blood cells function as a surveillance system for damaged tissue in Drosophila larvae

2008 • 158 citations

Activation of the Flt3 signal transduction cascade rescues and enhances type I interferon–producing and dendritic cell development

2006 • 156 citations

CXCL4 Downregulates the Atheroprotective Hemoglobin Receptor CD163 in Human Macrophages

2009 • 154 citations

Relationships between Distinct Blood Monocyte Subsets and Migrating Intestinal Lymph Dendritic Cells In Vivo under Steady-State Conditions

2006 • 148 citations

Cytokine regulation of the macrophage (M phi) system studied using the colony stimulating factor-1-deficient op/op mouse

1996 • 148 citations

Undertaker, a Drosophila Junctophilin, Links Draper-Mediated Phagocytosis and Calcium Homeostasis

2008 • 130 citations

Memory CD8+ T cells mediate antibacterial immunity via CCL3 activation of TNF/ROI+ phagocytes

2007 • 100 citations

Development of Macrophages with Altered Actin Organization in the Absence of MafB

2006 • 71 citations

Towards an understanding of the transcription factor network of dendritic cell development

2006 • 64 citations

p21Cip1 Is Required for the Development of Monocytes and Their Response to Serum Transfer-induced Arthritis

2006 • 36 citations