The longer-term impacts of Western diet on human cognition and the brain

Prevalence and Trends in Obesity Among US Adults, 1999-2008

2010 • 7,684 citations

LOSS OF RECENT MEMORY AFTER BILATERAL HIPPOCAMPAL LESIONS

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Mild cognitive impairment as a diagnostic entity

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Place navigation impaired in rats with hippocampal lesions

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Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

2000 • 4,169 citations

Exercise training increases size of hippocampus and improves memory

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The BDNF val66met Polymorphism Affects Activity-Dependent Secretion of BDNF and Human Memory and Hippocampal Function

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Dietary Carcinogens and Anticarcinogens

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Working memory, short-term memory, and general fluid intelligence: A latent-variable approach.

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n−3 Polyunsaturated fatty acids, inflammation, and inflammatory diseases

2006 • 2,422 citations

Origins and evolution of the Western diet: health implications for the 21st century1,2

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Oxidative stress in Parkinson's disease

2003 • 2,001 citations

Human amnesia and the medial temporal region: enduring memory impairment following a bilateral lesion limited to field CA1 of the hippocampus

1986 • 1,978 citations

Persistent activity in the prefrontal cortex during working memory

2003 • 1,950 citations

Oxidative Damage Is the Earliest Event in Alzheimer Disease

2001 • 1,833 citations

Food reward: Brain substrates of wanting and liking

1996 • 1,831 citations

Brain dopamine and obesity

2001 • 1,817 citations

Dietary Fat Intake and the Risk of Coronary Heart Disease in Women

1997 • 1,785 citations

Dietary Fiber, Glycemic Load, and Risk of Non—insulin-dependent Diabetes Mellitus in Women

1997 • 1,713 citations

Cause-Specific Excess Deaths Associated With Underweight, Overweight, and Obesity

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Molecular cloning and expression of brain-derived neurotrophic factor

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Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats

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The Rise of Supermarkets in Africa, Asia, and Latin America

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The Nutrition Transition: New Trends in the Global Diet

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DISEASES OF THE MITOCHONDRIAL DNA

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Evidence for sugar addiction: Behavioral and neurochemical effects of intermittent, excessive sugar intake

2007 • 1,250 citations

A prospective study of dietary glycemic load, carbohydrate intake, and risk of coronary heart disease in US women

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Affective neuroscience of pleasure: reward in humans and animals

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Dietary fat intake does affect obesity!

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Fructose, weight gain, and the insulin resistance syndrome,,

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Brain-Derived Neurotrophic Factor val⁶⁶met Polymorphism Affects Human Memory-Related Hippocampal Activity and Predicts Memory Performance

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BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease

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Neurobiology of Executive Functions: Catecholamine Influences on Prefrontal Cortical Functions

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Dietary fat intake and the risk of incident dementia in the Rotterdam study

1997 • 873 citations

A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learning

2002 • 853 citations

Blood–brain Barrier: Structural Components and Function Under Physiologic and Pathologic Conditions

2006 • 823 citations

Increased Lipid Peroxidation Precedes Amyloid Plaque Formation in an Animal Model of Alzheimer Amyloidosis

2001 • 776 citations

Overlapping neuronal circuits in addiction and obesity: evidence of systems pathology

2008 • 776 citations

Diet and risk of Type II diabetes: the role of types of fat and carbohydrate

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Perseverative interference in monkeys following selective lesions of the inferior prefrontal convexity

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Frontal-subcortical circuits and neuropsychiatric disorders

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High Glycemic Index Foods, Overeating, and Obesity

1999 • 703 citations

Diet‐induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle‐aged rats

2008 • 680 citations

Increased consumption of refined carbohydrates and the epidemic of type 2 diabetes in the United States: an ecologic assessment

2004 • 673 citations

Dietary saturated fats and their food sources in relation to the risk of coronary heart disease in women

1999 • 663 citations

Trends in Energy Intake in U.S. between 1977 and 1996: Similar Shifts Seen across Age Groups

2002 • 650 citations

Neuroanatomical correlates of hunger and satiation in humans using positron emission tomography

1999 • 583 citations

A Genetic Variant BDNF Polymorphism Alters Extinction Learning in Both Mouse and Human

2010 • 578 citations

Low dopamine striatal D2 receptors are associated with prefrontal metabolism in obese subjects: Possible contributing factors

2008 • 554 citations

Object recognition memory and the rodent hippocampus

2009 • 542 citations

Cognitive impairment following high fat diet consumption is associated with brain inflammation

2009 • 535 citations

Evidence That Intermittent, Excessive Sugar Intake Causes Endogenous Opioid Dependence

2002 • 528 citations

Dietary intake of fatty acids and fish in relation to cognitive performance at middle age

2004 • 517 citations

Dietary Fats and the Risk of Incident Alzheimer Disease

2003 • 505 citations

Learning Deficit in BDNF Mutant Mice

1997 • 470 citations

Obesity and the brain: how convincing is the addiction model?

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Don't mind if I do: Disinhibited eating under cognitive load.

2000 • 422 citations

Food Combination and Alzheimer Disease Risk

2010 • 405 citations

Perseveration in extinction and in discrimination reversal tasks following selective frontal ablations in Macaca mulatta

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The interplay between oxidative stress and brain‐derived neurotrophic factor modulates the outcome of a saturated fat diet on synaptic plasticity and cognition

2004 • 386 citations

Deletion of TrkB in adult progenitors alters newborn neuron integration into hippocampal circuits and increases anxiety-like behavior

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Replacing Fats and Sweets With Vegetables and Fruits—A Question of Cost

2004 • 374 citations

Diet, nutrition and the prevention of type 2 diabetes

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Obesity, diabetes and cognitive deficit: The Framingham Heart Study

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NIDDM and Blood Pressure as Risk Factors for Poor Cognitive Performance: The Framingham Study

1997 • 366 citations

Dietary intake and cognitive function in a group of elderly people

1997 • 354 citations

Attention-deficit/hyperactivity disorder: a life-span perspective.

1998 • 352 citations

Refined food addiction: A classic substance use disorder

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Reactive oxygen species

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Exercise reverses the harmful effects of consumption of a high-fat diet on synaptic and behavioral plasticity associated to the action of brain-derived neurotrophic factor

2003 • 337 citations

Intake of Sucrose-sweetened Water Induces Insulin Resistance and Exacerbates Memory Deficits and Amyloidosis in a Transgenic Mouse Model of Alzheimer Disease

2007 • 321 citations

The human entorhinal cortex: normal morphology and lamina-specific pathology in various diseases

1992 • 320 citations

Fat intake at midlife and cognitive impairment later in life: a population‐based CAIDE study

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Sweeteners and Risk of Obesity and Type 2 Diabetes: The Role of Sugar-Sweetened Beverages

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Dietary fat intake and 6-year cognitive change in an older biracial community population

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Dietary lipids and antioxidants in Parkinson's disease: A population‐based, case‐control study

1996 • 295 citations

Differential brain responses to satiation in obese and lean men.

2000 • 290 citations

Dopamine D2 Receptor Availability in Opiate-Dependent Subjects before and after Naloxone-Precipitated Withdrawal

1997 • 286 citations

Dietary patterns and 15-y risks of major coronary events, diabetes, and mortality

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The Effects of a High-Energy Diet on Hippocampal Function and Blood-Brain Barrier Integrity in the Rat

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Effects of a Saturated Fat and High Cholesterol Diet on Memory and Hippocampal Morphology in the Middle-Aged Rat

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High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice: implications for decreased Nrf2 signaling

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High dietary fat induces NADPH oxidase-associated oxidative stress and inflammation in rat cerebral cortex

2004 • 264 citations

Fatty acid analysis of wild ruminant tissues: evolutionary implications for reducing diet-related chronic disease

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What Causes Humans to Begin and End a Meal? A Role for Memory for What Has Been Eaten, as Evidenced by a Study of Multiple Meal Eating in Amnesic Patients

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FMRI of the prefrontal cortex during overt verbal fluency

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BCL-2 expression or antioxidants prevent hyperglycemia-induced formation of intracellular advanced glycation endproducts in bovine endothelial cells.

1996 • 251 citations

Successful dieters have increased neural activity in cortical areas involved in the control of behavior

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Glucose enhancement of performance of memory tests in young and aged humans

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Opioids for hedonic experience and dopamine to get ready for it

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The radial arm maze as a tool in behavioral pharmacology

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Effects of high fat diet on Morris maze performance, oxidative stress, and inflammation in rats: Contributions of maternal diet

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ADHD Is Associated With a “Western” Dietary Pattern in Adolescents

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Type 2 Diabetes and Cognitive Function in Community-Dwelling Elderly Women

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The effects of energy-rich diets on discrimination reversal learning and on BDNF in the hippocampus and prefrontal cortex of the rat

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Glucose enhancement of memory in patients with probable senile dementia of the Alzheimer's type

1993 • 207 citations

What are the key food groups to target for preventing obesity and improving nutrition in schools?

2004 • 204 citations

Environmental, life-style, and physical precursors of clinical Parkinson?s disease: recent findings from the Honolulu-Asia Aging Study

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Changes in diet and physical activity affect the body mass index of Chinese adults

1998 • 189 citations

Learning and memory impairment in rats fed a high saturated fat diet

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Sugar and Cardiovascular Disease

2002 • 189 citations

Vascular Lipotoxicity: Endothelial Dysfunction via Fatty-Acid-Induced Reactive Oxygen Species Overproduction in Obese Zucker Diabetic Fatty Rats

2006 • 186 citations

Cognitive performance is associated with glucose regulation in healthy elderly persons and can be enhanced with glucose and dietary carbohydrates

2000 • 185 citations

The effects of a high-energy diet on hippocampal-dependent discrimination performance and blood–brain barrier integrity differ for diet-induced obese and diet-resistant rats

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The involvement of the orbitofrontal cortex in learning under changing task contingencies

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Cognitive restraint can be offset by distraction, leading to increased meal intake in women

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Diminished ability to interpret and report internal states after bilateral medial temporal resection: Case H.M.

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Memory inhibition and energy regulation

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Higher reported saturated fat and refined sugar intake is associated with reduced hippocampal-dependent memory and sensitivity to interoceptive signals.

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Consumption of Soft Drinks and Hyperactivity, Mental Distress, and Conduct Problems Among Adolescents in Oslo, Norway

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Adult nutrient intake as a risk factor for Parkinson's disease

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Diminished ability to interpret and report internal states after bilateral medial temporal resection: Case H.M.

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Memory for recent eating and its influence on subsequent food intake

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Highly palatable diet consumption increases protein oxidation in rat frontal cortex and anxiety-like behavior

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Gastric stimulation in obese subjects activates the hippocampus and other regions involved in brain reward circuitry

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A high-fat diet impairs cardiac high-energy phosphate metabolism and cognitive function in healthy human subjects

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Diet-induced obesity and spatial cognition in young male rats

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Adipose tissue: A motor for the inflammation associated with obesity

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Diet Intervention and Cerebrospinal Fluid Biomarkers in Amnestic Mild Cognitive Impairment

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Comparison of the Effects on Insulin Sensitivity of High Carbohydrate and High Fat Diets in Normal Subjects*

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Nutrition transition and global dietary trends

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Dietary fat types and 4‐year cognitive change in community‐dwelling older women

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Nutritional and dietary influences on attention deficit hyperactivity disorder

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Does consumption of processed foods explain disparities in the body weight of individuals? The case of Guatemala

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The effects of self-attention and public attention on eating in restrained and unrestrained subjects.

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Dietary protein, carbohydrate, and fat enhance memory performance in the healthy elderly

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Cognitive impairment in rats fed high-fat diets: A specific effect of saturated fatty-acid intake.

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Inhibitory Changes After Age 60 and Their Relationship to Measures of Attention and Memory

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The influence of the glycaemic load of breakfast on the behaviour of children in school

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Rats that binge eat fat-rich food do not show somatic signs or anxiety associated with opiate-like withdrawal: Implications for nutrient-specific food addiction behaviors

2011 • 119 citations

Short‐term consumption of a high‐fat diet impairs whole‐body efficiency and cognitive function in sedentary men

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Obesity-mediated inflammation may damage the brain circuit that regulates food intake

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Dietary correlates of hyperactive behavior in children.

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Correlation between hippocampal BDNF mRNA expression and memory performance in senescent rats

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Diet and Parkinson's disease I

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Early life exposure to a high fat diet promotes long-term changes in dietary preferences and central reward signaling

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Prevalence of obesity in Australia

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Experimental Cross-Validation of DSM-IV Types of Attention-Deficit/Hyperactivity Disorder

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Dietary correlates of hyperactive behavior in children.

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Sucrose-induced obesity impairs novel object recognition learning in young rats

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Effects of sucrose ingestion on the behavior of hyperactive boys

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Body mass predicts orbitofrontal activity during visual presentations of high-calorie foods

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Nutrition in the treatment of attention-deficit hyperactivity disorder: a neglected but important aspect.

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Vascular Changes in Rat Hippocampus following a High Saturated Fat and Cholesterol Diet

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Mid‐life adiposity factors relate to blood–brain barrier integrity in late life

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Excitotoxic lesions restricted to the dorsal CA1 field of the hippocampus impair spatial memory and extinction learning in C57BL/6 mice

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The effects of self-attention and public attention on eating in restrained and unrestrained subjects.

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Better cognitive performance following a low-glycaemic-index compared with a high-glycaemic-index carbohydrate meal in adults with type 2 diabetes

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Monounsaturated, Trans, and Saturated Fatty Acids and Cognitive Decline in Women

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Education Attenuates the Association between Dietary Patterns and Cognition

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High fat feeding promotes simultaneous decline in insulin sensitivity and cognitive performance in a delayed matching and non-matching to position task

2010 • 88 citations

Snacking while watching TV impairs food recall and promotes food intake on a later TV free test meal

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The Emerging Link Between Alcoholism Risk and Obesity in the United States

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Dietary Fat Intake and Cognitive Decline in Women With Type 2 Diabetes

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High-fat diet decreases tyrosine hydroxylase mRNA expression irrespective of obesity susceptibility in mice

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The 2008 ESPEN Sir David Cuthbertson lecture: Fatty acids and inflammation – From the membrane to the nucleus and from the laboratory bench to the clinic

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Feed-forward mechanisms: Addiction-like behavioral and molecular adaptations in overeating

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Comparable data on food and nutrient intake and physical measurements from the 1983, 1985 and 1995 national nutrition surveys

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Regions of the human brain affected during a liquid-meal taste perception in the fasting state: a positron emission tomography study

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Bilateral and limited amygdalohippocampal lesions causing a pure amnesic syndrome

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The influence on cognition of the interaction between the macro-nutrient content of breakfast and glucose tolerance

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Dietary iron, animal fats, and risk of Parkinson's disease.

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Excitotoxic lesions of the hippocampus disrupt runway but not consummatory contrast

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Hebb, Pandemonium and Catastrophic Hypermnesia: The Hippocampus as a Suppressor of Inappropriate Associations

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Insulin Modulates Cocaine-Sensitive Monoamine Transporter Function and Impulsive Behavior

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Altered morphology of hippocampal dentate granule cell presynaptic and postsynaptic terminals following conditional deletion of TrkB

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Agricultural policies, food and public health

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Sugar challenge testing with children considered behaviorally "sugar reactive."

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Energy-restricted pair-feeding normalizes low levels of brain-derived neurotrophic factor/tyrosine kinase B mRNA expression in the hippocampus, but not ventromedial hypothalamic nucleus, in diet-induced obese mice

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Dietary Factors Affect Food Reward and Motivation to Eat

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Diabetes, Hyperinsulinemia, and Hyperlipidemia in Small Aboriginal Community in Northern Australia

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Glucose tolerance and cognitive impairment in an elderly population

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Antioxidant vitamins reduce acute meal-induced memory deficits in adults with type 2 diabetes

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Frontal degenerative dementia and neuroimaging.

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