The Molecular Mechanism of Programmed Cell Death in C. elegans

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

1998 • 14,674 citations

Caspases: Enemies Within

1998 • 6,923 citations

The Bcl-2 Protein Family: Arbiters of Cell Survival

1998 • 5,359 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

1998 • 4,383 citations

The embryonic cell lineage of the nematode Caenorhabditis elegans

1983 • 4,070 citations

Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

1998 • 3,603 citations

Post-embryonic cell lineages of the nematode, Caenorhabditis elegans

1977 • 3,432 citations

Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.

1995 • 2,877 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis

1997 • 1,848 citations

Genetic control of programmed cell death in the nematode C. elegans

1986 • 1,790 citations

BCL-2 FAMILY: Regulators of Cell Death

1998 • 1,687 citations

Caspase-3-Generated Fragment of Gelsolin: Effector of Morphological Change in Apoptosis

1997 • 1,233 citations

Caenorhabditis elegans gene ced-9 protects cells from programmed cell death

1992 • 889 citations

Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis.

1992 • 818 citations

Membrane and Morphological Changes in Apoptotic Cells Regulated by Caspase-Mediated Activation of PAK2

1997 • 742 citations

EGG-LAYING DEFECTIVE MUTANTS OF THE NEMATODE CAENORHABDITIS ELEGANS

1983 • 730 citations

Human CD14 mediates recognition and phagocytosis of apoptotic cells

1998 • 685 citations

The C. elegans Protein EGL-1 Is Required for Programmed Cell Death and Interacts with the Bcl-2–like Protein CED-9

1998 • 628 citations

Prevention of Programmed Cell Death in Caenorhabditis elegans by Human bcl-2

1992 • 608 citations

Different populations of macrophages use either the vitronectin receptor or the phosphatidylserine receptor to recognize and remove apoptotic cells.

1992 • 605 citations

Proteolysis of Fodrin (Non-erythroid Spectrin) during Apoptosis

1995 • 539 citations

The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis

1998 • 534 citations

Bcl-X _L interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation

1998 • 534 citations

Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis.

1996 • 529 citations

Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution.

1995 • 524 citations

Caspase-9, Bcl-XL, and Apaf-1 Form a Ternary Complex

1998 • 523 citations

A genetic pathway for the development of the Caenorhabditis elegans HSN motor neurons

1988 • 476 citations

Genes required for the engulfment of cell corpses during programmed cell death in Caenorhabditis elegans.

1991 • 463 citations

Macrophage recognition of cells undergoing programmed cell death (apoptosis).

1985 • 460 citations

Role for the class A macrophage scavenger receptor in the phagocytosis of apoptotic thymocytes in vitro.

1996 • 427 citations

Low molecular weight heparins: prophylaxis of venous thromboembolism in surgical patients.

1997 • 399 citations

Croquemort, A Novel Drosophila Hemocyte/Macrophage Receptor that Recognizes Apoptotic Cells

1996 • 394 citations

CD36 gene transfer confers capacity for phagocytosis of cells undergoing apoptosis.

1995 • 392 citations

Mutations Affecting Programmed Cell Deaths in the Nematode Caenorhabditis elegans s

1983 • 389 citations

The Caenorhabditis elegans cell death gene ced-4 encodes a novel protein and is expressed during the period of extensive programmed cell death

1992 • 387 citations

C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180

1998 • 377 citations

Ultrastructural localization of bcl-2 protein.

1992 • 351 citations

Interaction and Regulation of Subcellular Localization of CED-4 by CED-9

1997 • 345 citations

DOCK180, a Major CRK-Binding Protein, Alters Cell Morphology upon Translocation to the Cell Membrane

1996 • 339 citations

The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease.

1996 • 331 citations

Regulated nuclear import of Rel proteins in the Drosophila immune response

1998 • 314 citations

Interaction between the C. elegans cell-death regulators CED-9 and CED-4

1997 • 304 citations

The ATP binding cassette transporter ABC1, is required for the engulfment of corpses generated by apoptotic cell death.

1996 • 294 citations

Multiple subcellular localization of bcl-2: detection in nuclear outer membrane, endoplasmic reticulum membrane, and mitochondrial membranes.

1994 • 290 citations

The C. elegans Cell Corpse Engulfment Gene ced-7 Encodes a Protein Similar to ABC Transporters

1998 • 278 citations

Essential Role of CED-4 Oligomerization in CED-3 Activation and Apoptosis

1998 • 269 citations

Drosophila myoblast city Encodes a Conserved Protein That Is Essential for Myoblast Fusion, Dorsal Closure, and Cytoskeletal Organization

1997 • 257 citations

The PTB domain: a new protein module implicated in signal transduction

1995 • 249 citations

PTB Domain Binding to Signaling Proteins Through a Sequence Motif Containing Phosphotyrosine

1995 • 245 citations

Developing Caenorhabditis elegans neurons may contain both cell-death protective and killer activities.

1996 • 236 citations

Candidate Adaptor Protein CED-6 Promotes the Engulfment of Apoptotic Cells in C. elegans

1998 • 199 citations

Activation of C. elegans cell death protein CED-9 by an ammo-acid substitution in a domain conserved in Bcl-2

1994 • 177 citations

Two C. elegans genes control the programmed deaths of specific cells in the pharynx

1991 • 171 citations

Caenorhabditis elegans CED-4 stimulates CED-3 processing and CED-3-induced

1997 • 168 citations

Transcriptional regulator of programmed cell death encoded by Caenorhabditis elegans gene ces-2

1996 • 164 citations

An Alternatively Spliced C. elegans ced-4 RNA Encodes a Novel Cell Death Inhibitor

1996 • 146 citations

CED-4 induces chromatin condensation in Schizosaccharomyces pombe and is inhibited by direct physical association with CED-9

1997 • 120 citations

The Bcl-2 family and cell death regulation

1998 • 119 citations

Identification of Multiple Caenorhabditis elegansCaspases and Their Potential Roles in Proteolytic Cascades

1998 • 89 citations

Direct physical interaction between the Caenorhabditis elegans ‘death proteins’ CED‐3 and CED‐4

1997 • 83 citations

Activation of Rho-Dependent Cell Spreading and Focal Adhesion Biogenesis by the v-Crk Adaptor Protein

1998 • 73 citations

Three-dimensional structures of proteins involved in programmed cell death

1997 • 72 citations

Integrin-mediated signaling in the regulation of osteoclast adhesion and activation

1998 • 66 citations

Localization of the Bcl-2 Protein to the Outer Mitochondrial Membrane by Electron Microscopy

1995 • 53 citations

Chromosomal Mapping of the Gene Encoding DOCK180, a Major Crk-Binding Protein, to 10q26.13–q26.3 by Fluorescencein SituHybridization

1996 • 5 citations