Effect of the lipid peroxidation product acrolein on tau phosphorylation in neural cells

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

1986 • 3,430 citations

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

1989 • 2,308 citations

Neurodegenerative Tauopathies

2001 • 2,276 citations

Oxidative Damage Is the Earliest Event in Alzheimer Disease

2001 • 1,833 citations

Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

2001 • 865 citations

Oxidative stress in Alzheimer’s disease

2000 • 857 citations

Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: Generation of paired helical filament epitopes and neuronal localisation of the kinase

1992 • 709 citations

Proline-directed and Non-proline-directed Phosphorylation of PHF-tau

1995 • 549 citations

Acrolein Is a Product of Lipid Peroxidation Reaction

1998 • 521 citations

Abnormal Alzheimer‐like phosphorylation of tau‐protein by cyclin‐dependent kinases cdk2 and cdk5

1993 • 470 citations

Distribution of Active Glycogen Synthase Kinase 3β (GSK-3β) in Brains Staged for Alzheimer Disease Neurofibrillary Changes

1999 • 448 citations

Acrolein is increased in Alzheimer’s disease brain and is toxic to primary hippocampal cultures

2001 • 438 citations

Glycogen synthase kinase 3β is identical to tau protein kinase I generating several epitopes of paired helical filaments

1993 • 397 citations

Protein‐Bound Acrolein

1999 • 394 citations

Abnormal phosphorylation of the microtubule-associated protein? (tau) in Alzheimer cytoskeletal pathology

1987 • 393 citations

p38 Kinase Is Activated in the Alzheimer's Disease Brain

1999 • 365 citations

Activation of p38 Kinase Links Tau Phosphorylation, Oxidative Stress, and Cell Cycle-Related Events in Alzheimer Disease

2000 • 355 citations

Lithium inhibits Alzheimer's disease‐like tau protein phosphorylation in neurons

1997 • 315 citations

Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the ‘two hit’ hypothesis

2001 • 309 citations

Phosphorylation of microtubule‐associated protein tau by stress‐activated protein kinases

1997 • 294 citations

Lithium protects cultured neurons against β‐amyloid‐induced neurodegeneration

1999 • 269 citations

Phosphorylation of tau proteins to a state like that in Alzheimer's brain is catalyzed by a calcium/calmodulin-dependent kinase and modulated by phospholipids.

1987 • 264 citations

Ca2+-dependent hydrophobic-interaction chromatography. Isolation of a novel Ca2+-binding protein and protein kinase C from bovine brain

1984 • 202 citations

Phosphorylated mitogen-activated protein kinase (MAPK/ERK-P), protein kinase of 38 kDa (p38-P), stress-activated protein kinase (SAPK/JNK-P), and calcium/calmodulin-dependent kinase II (CaM kinase II) are differentially expressed in tau deposits in neurons and glial cells in tauopathies

2001 • 199 citations

Implication of brain cdc2 and MAP2 kinases in the phosphorylation of tau protein in Alzheimer's disease

1992 • 190 citations

Microtubule-associated protein tau is phosphorylated by protein kinase C on its tubulin binding domain.

1992 • 171 citations

Activation of the JNK/p38 Pathway Occurs in Diseases Characterized by Tau Protein Pathology and Is Related to Tau Phosphorylation But Not to Apoptosis

2001 • 169 citations

Differential Assembly of Human Tau Isoforms in the Presence of Arachidonic Acid

2000 • 165 citations

Reactivating Kinase/p38 Phosphorylates τ Protein In Vitro

1997 • 155 citations

Inhibition of neutrophil apoptosis by acrolein: a mechanism of tobacco-related lung disease?

2001 • 109 citations

Phosphorylated, but not native, tau protein assembles following reaction with the lipid peroxidation product, 4‐hydroxy‐2‐nonenal

2000 • 108 citations

Aβ amyloidosis induces the initial stage of tau accumulation in APPSw mice

2001 • 95 citations

Immunocytochemistry of tau phosphoserine 413 and tau protein kinase I in Alzheimer pathology

1996 • 65 citations

Comparison of the phosphorylation of microtubule-associated protein tau by non-proline dependent protein kinases

1994 • 53 citations

Acrolein induces activation of the epidermal growth factor receptor of human keratinocytes for cell death

2001 • 38 citations

High-dose chemotherapy-induced platelet defect: inhibition of platelet signal transduction pathways.

1993 • 24 citations

Microtubule-associated protein 2 phosphorylation is decreased in the human epileptic temporal lobe cortex

2001 • 14 citations

Protein kinases involved in the phosphorylation of human tau protein in transfected COS-1 cells

1996 • 9 citations