Lithium protects cultured neurons against β‐amyloid‐induced neurodegeneration

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

1986 • 3,430 citations

Growth of a rat neuroblastoma cell line in serum-free supplemented medium.

1979 • 2,285 citations

A molecular mechanism for the effect of lithium on development.

1996 • 2,270 citations

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

1997 • 1,438 citations

Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease

1997 • 1,395 citations

Lithium inhibits glycogen synthase kinase-3 activity and mimics Wingless signalling in intact cells

1996 • 1,299 citations

Role of Glycogen Synthase Kinase-3 in the Phosphatidylinositol 3-Kinase/Akt Cell Survival Pathway

1998 • 1,049 citations

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons.

1993 • 1,035 citations

Neural and developmental actions of lithium: A unifying hypothesis

1989 • 1,005 citations

Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives

1997 • 991 citations

Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain.

1989 • 989 citations

Mechanisms of Neuronal Degeneration in Alzheimer's Disease

1996 • 956 citations

In vitro aging of ß-amyloid protein causes peptide aggregation and neurotoxicity

1991 • 833 citations

Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules

1996 • 807 citations

Amyloid β-Protein and the Genetics of Alzheimer's Disease

1996 • 794 citations

Accumulation of abnormally phosphorylated τ precedes the formation of neurofibrillary tangles in Alzheimer's disease

1989 • 783 citations

Activation of the Wnt Signaling Pathway: A Molecular Mechanism for Lithium Action

1997 • 627 citations

β-Amyloid fibrils induce tau phosphorylation and loss of microtubule binding

1995 • 580 citations

Insulin and Insulin-like Growth Factor-1 Regulate Tau Phosphorylation in Cultured Human Neurons

1997 • 517 citations

Aging renders the brain vulnerable to amyloid β-protein neurotoxicity

1998 • 513 citations

Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau.

1992 • 509 citations

Monoclonal antibody PHF‐1 recognizes tau protein phosphorylated at serine residues 396 and 404

1994 • 451 citations

Chronic lithium treatment robustly protects neurons in the central nervous system against excitotoxicity by inhibiting N -methyl- <scp>d</scp> -aspartate receptor-mediated calcium influx

1998 • 422 citations

Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity.

1993 • 379 citations

Survival and growth of hippocampal neurons in defined medium at low density: advantages of a sandwich culture technique or low oxygen

1989 • 376 citations

Apoptosis mediated neurotoxicity induced by chronic application of β amyloid fragment 25–35

1993 • 343 citations

Chapter 10 Calcium, Free Radicals, and Excitotoxic Neuronal Death in Primary Cell Culture

1995 • 338 citations

Insulin-like growth factor I protects and rescues hippocampal neurons against β-amyloid- and human amylin-induced toxicity

1997 • 325 citations

Lithium inhibits Alzheimer's disease‐like tau protein phosphorylation in neurons

1997 • 315 citations

Activation of tau protein kinase I/glycogen synthase kinase-3β by amyloid β peptide (25–35) enhances phosphorylation of tau in hippocampal neurons

1998 • 281 citations

Discussion

1997 • 279 citations

Regulation of mitochondrial pyruvate dehydrogenase activity by tau protein kinase I/glycogen synthase kinase 3beta in brain.

1996 • 265 citations

Filamentous nerve cell inclusions in neurodegenerative diseases

1998 • 261 citations

Aggregated Amyloid-β Protein Induces Cortical Neuronal Apoptosis and Concomitant “Apoptotic” Pattern of Gene Induction

1997 • 261 citations

Difference between the tau protein of Alzheimer paired helical filament core and normal tau revealed by epitope analysis of monoclonal antibodies 423 and 7.51.

1991 • 214 citations

Mood Stabilizer Combinations: A Review of Safety and Efficacy

1998 • 202 citations

Recognition of the minimal epitope of monoclonal antibody Tau‐1 depends upon the presence of a phosphate group but not its location

1993 • 190 citations

Selective Phosphorylation of Adult Tau Isoforms in Mature Hippocampal Neurons Exposed to Fibrillar Aβ

1997 • 174 citations

GSK3: a SHAGGY frog story

1996 • 150 citations

Tau protein I is essential for amyloid β-protein iduced neurotoxicity

1993 • 125 citations

Lithium Induces Apoptosis in Immature Cerebellar Granule Cells but Promotes Survival of Mature Neurons

1994 • 119 citations

Immunocytochemistry of tau phosphoserine 413 and tau protein kinase I in Alzheimer pathology

1996 • 65 citations

Lithium: A Brake in the Rising Cost of Mental Illness

1980 • 60 citations

Protection by pyruvate and malate against glutamate-mediated neurotoxicity.

1998 • 58 citations

β‐Amyloid‐Induced Neurotoxicity of a Hybrid Septal Cell Line Associated with Increased Tau Phosphorylation and Expression of β‐Amyloid Precursor Protein

1997 • 48 citations

The role of pyruvate in neuronal calcium homeostasis. Effects on intracellular calcium pools.

1994 • 34 citations

Tyrosine kinase inhibitors and cycloheximide inhibit Li+ protection of cerebellar granule neurons switched to non-depolarizing medium

1996 • 24 citations

Chronic pre-explant blockade of the NMDA receptor affects survival of cerebellar granule cells explanted in vitro

1997 • 23 citations

Disruption by Lithium of Phosphoinositide Signalling in Cerebellar Granule Cells in Primary Culture

1998 • 20 citations