Expression of human cytochrome P450 enzymes in yeast and bacteria and relevance to studies on catalytic specificity

Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism.

1986 • 734 citations

Characterization of translational initiation sites inE. coli

1982 • 673 citations

Expression and enzymatic activity of recombinant cytochrome P450 17 alpha-hydroxylase in Escherichia coli.

1991 • 547 citations

Cyclosporine metabolism in human liver: Identification of a cytochrome P-450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs

1988 • 539 citations

Studies on the expression and metabolic capabilities of human liver cytochrome P450IIIA5 (HLp3).

1990 • 402 citations

High-level expression of sperm whale myoglobin in Escherichia coli.

1987 • 338 citations

Identification of an inducible form of cytochrome P-450 in human liver.

1985 • 320 citations

Oxidation of 4-aryl- and 4-alkyl-substituted 2,6-dimethyl-3,5-bis(alkoxycarbonyl)-1,4-dihydropyridines by human liver microsomes and immunochemical evidence for the involvement of a form of cytochrome P-450

1986 • 318 citations

Metabolism of cyclosporin A. IV. Purification and identification of the rifampicin-inducible human liver cytochrome P-450 (cyclosporin A oxidase) as a product of P450IIIA gene subfamily.

1989 • 303 citations

Evidence for cytochrome P-450NF, the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver.

1989 • 303 citations

Oxidation of dihydropyridine calcium channel blockers and analogs by human liver cytochrome P-450 IIIA4

1991 • 262 citations

Human liver microsomal cytochrome P-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism. Purification and characterization of two similar forms involved in the reaction.

1986 • 258 citations

Characterization of Human Microsomal Cytochrome P-450 Enzymes

1989 • 244 citations

Tolbutamide and mephenytoin hydroxylation by human cytochrome P450s in the CYP2C subfamily.

1990 • 218 citations

Catalytic activities of human liver cytochrome P-450 IIIA4 expressed in Saccharomyces cerevisiae

1990 • 207 citations

Fetus-specific expression of a form of cytochrome P-450 in human livers

1990 • 205 citations

Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily

1991 • 200 citations

Synthesis, bacterial expression, and mutagenesis of the gene coding for mammalian cytochrome b5.

1986 • 151 citations

Alcohol-inducible cytochrome P-450IIE1 lacking the hydrophobic NH2-terminal segment retains catalytic activity and is membrane-bound when expressed in Escherichia coli

1991 • 145 citations

Expression of a human liver cytochrome P-450 protein with tolbutamide hydroxylase activity in Saccharomyces cerevisiae

1989 • 134 citations

Hepatic metabolism of tolbutamide: characterization of the form of cytochrome P-450 involved in methyl hydroxylation and relationship to in vivo disposition.

1987 • 130 citations

Characterization of mRNA Species Related to Human Liver Cytochrome P-450 Nifedipine Oxidase and the Regulation of Catalytic Activity

1989 • 123 citations

Oxidation of aflatoxins and sterigmatocystin by human liver microsomes: significance of aflatoxin Q1 as a detoxication product of aflatoxin B1

1992 • 118 citations

Characterization of cDNAs, mRNAs, and proteins related to human liver microsomal cytochrome P-450 S-mephenytoin 4-hydroxylase

1988 • 106 citations

Separation of human liver microsomal tolbutamide hydroxylase and (S)-mephenytoin 4'-hydroxylase cytochrome P-450 enzymes.

1991 • 98 citations

Oxidative cleavage of carboxylic esters by cytochrome P-450.

1987 • 83 citations

Novel exogenous heme-dependent expression of mammalian cytochrome P450 using baculovirus

1989 • 83 citations

The expression of a catalytically active cholesterol 7 alpha-hydroxylase cytochrome P450 in Escherichia coli.

1991 • 81 citations

Expression of a functional 78,000 dalton mammalian flavoprotein, NADPH-cytochrome P-450 oxidoreductase, in Escherichia coli

1987 • 74 citations

Gene Expression Technology

1990 • 72 citations

[14] Expression of mammalian cytochrome P450 enzymes using yeast-based vectors

1991 • 54 citations

Expression of a human P-450IIC gene in yeast cells using galactose-inducible expression system.

1989 • 46 citations

Characterization of Rat Cytochrome P-450MC Synthesized in Saccharomyces cerevisiae1

1985 • 45 citations

Polymerase chain reaction-directed identification, cloning, and quantification of human CYP2C18 mRNA.

1991 • 43 citations

Contributions of human liver cytochrome P450 enzymes to the N-oxidation of 4,4′-methylene-bis(2-chloroaniline)

1992 • 33 citations

The expression of human cytochrome P450IA1 in the yeast Saccharomyces cerevisiae

1991 • 24 citations

Expression and characterization of a rabbit liver cytochrome P450 belonging to P450IIB subfamily with the aid of the baculovirus expression vector system

1991 • 21 citations

Expression of a Rat Liver Microsomal Cytochrome P-450 Catalyzing Testosterone 16α-Hydroxylation in Saccharomyces cerevisiae: Vitamin D3 25-Hydroxylase and Testosterone 16α-Hydroxylase Are Distinct Forms of Cytochrome P-450

1988 • 17 citations

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