Epidemiology of sepsis: An update

Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis

1992 • 12,726 citations

The Natural History of the Systemic Inflammatory Response Syndrome (SIRS)

1995 • 2,007 citations

Plasma Cytokine and Endotoxin Levels Correlate with Survival in Patients with the Sepsis Syndrome

1993 • 1,068 citations

Incidence, risk factors, and outcome of severe sepsis and septic shock in adults. A multicenter prospective study in intensive care units. French ICU Group for Severe Sepsis

1995 • 886 citations

Serum Cytokine Levels in Human Septic Shock

1993 • 882 citations

Association of TNF2, a TNF-α Promoter Polymorphism, With Septic Shock Susceptibility and Mortality

1999 • 732 citations

Incidence, Risk Factors, and Outcome of Severe Sepsis and Septic Shock in Adults

1995 • 699 citations

Epidemiology of Sepsis Syndrome in 8 Academic Medical Centers

1997 • 662 citations

Has the mortality of septic shock changed with time?

1998 • 616 citations

A genomic polymorphism within the tumor necrosis factor locus influences plasma tumor necrosis factor-alpha concentrations and outcome of patients with severe sepsis

1996 • 564 citations

EFFECT OF GENDER AND SEX HORMONES ON IMMUNE RESPONSES FOLLOWING SHOCK

2000 • 526 citations

Tumor necrosis factor and interleukin-1 serum levels during severe sepsis in humans

1989 • 485 citations

Dear SIRS, I'm sorry to say that I don't like you

1997 • 446 citations

High circulating levels of interleukin-6 in patients with septic shock: Evolution during sepsis, prognostic value, and interplay with other cytokines

1991 • 446 citations

Incidence and mortality of severe sepsis in surgical intensive care patients: the influence of patient gender on disease process and outcome

2000 • 369 citations

Assessment of the safety and efficacy of the monoclonal anti-tumor necrosis factor antibody-fragment, MAK 195F, in patients with sepsis and septic shock

1996 • 368 citations

Plasma Tumor Necrosis Factor in Patients with Septic Shock: Mortality Rate, Incidence of Adult Respiratory Distress Syndrome, and Effects of Methylprednisolone Administration

1990 • 335 citations

Variation in the Tumor Necrosis Factor- Gene Promoter Region May Be Associated with Death from Meningococcal Disease

1996 • 308 citations

Long-term Survival and Function After Suspected Gram-negative Sepsis

1995 • 308 citations

Epidemiology of sepsis syndrome in 8 academic medical centers. Academic Medical Center Consortium Sepsis Project Working Group

1997 • 260 citations

Clinical Gram-positive sepsis

1999 • 257 citations

The Italian SEPSIS study: Preliminary results on the incidence and evolution of SIRS, sepsis, severe sepsis and septic shock

1995 • 257 citations

An overview of mortality risk prediction in sepsis

1995 • 251 citations

-308 tumor necrosis factor (TNF) polymorphism is not associated with survival in severe sepsis and is unrelated to lipopolysaccharide inducibility of the human TNF promoter.

1995 • 247 citations

Septic shock

1998 • 229 citations

Comparison of two polymorphisms of the interleukin-1 gene family

1999 • 221 citations

Relation of a TNF Gene Polymorphism to Severe Sepsis in Trauma Patients

1999 • 218 citations

Bedside prediction of mortality from bacteremic sepsis. A dynamic analysis of ICU patients.

1996 • 217 citations

The Clinical Evaluation of New Drugs for Sepsis

1993 • 202 citations

Customized probability models for early severe sepsis in adult intensive care patients. Intensive Care Unit Scoring Group.

1995 • 171 citations

Long-term survival after intensive care unit admission with sepsis

1995 • 159 citations

Infant mortality among racial/ethnic minority groups, 1983-1984.

1990 • 146 citations

Nosocomial bacteremia in a medical-surgical intensive care unit: Epidemiologic characteristics and factors influencing mortality in 111 episodes

1994 • 144 citations

Customized probability models for early severe sepsis in adult intensive care patients. Intensive Care Unit Scoring Group

1995 • 134 citations

A prospective study of the use of a dobutamine stress test to identify outcome in patients with sepsis, severe sepsis, or septic shock

1999 • 116 citations

Gender Differences in Sepsis: Genetically Determined?

2000 • 113 citations

Use of Predicted Risk of Mortality to evaluate the efficacy of anticytokine therapy in sepsis

1996 • 111 citations

THE EPIDEMIOLOGY OF BACTERIAL SEPSIS

1999 • 108 citations

GENDER DIFFERENCES IN SEPSIS: GENETICALLY DETERMINED?

2000 • 100 citations

The Sepsis Syndrome in a Dutch University Hospital

1993 • 100 citations

COMMUNITY-ACQUIRED PNEUMONIA: EPIDEMIOLOGY, ETIOLOGY, TREATMENT

1998 • 95 citations

Analysis of two human leukocyte antigen-linked polymorphic heat shock protein 70 genes in patients with severe sepsis

1999 • 79 citations

AGE-SPECIFIC INCIDENCE AND OUTCOME OF SEPSIS IN THE US

1999 • 54 citations

GENDER-RELATED THERAPY: EARLY IL-10 ADMINISTRATION AFTER HEMORRHAGE RESTORES IMMUNE FUNCTION IN MALES BUT NOT IN FEMALES

2000 • 23 citations

Reduced mortality from septic shock-Lessons for the future

1998 • 14 citations

Discourse on Method: Measuring the Value of New Therapies in Intensive Care

1998 • 6 citations

The dobutamine oxygen flux test: A road map to outcome in sepsis?

1999 • 4 citations

The Molecular Genetics of Sepsis: Clinical Epidemiology Considerations

2000 • 2 citations

Quantifying Risk in Sepsis: A Review of Illness Severity and Organ Dysfunction Scoring

2005 • 1 citations