Use of Predicted Risk of Mortality to evaluate the efficacy of anticytokine therapy in sepsis

Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis

1992 • 12,726 citations

APACHE II-A Severity of Disease Classification System

1986 • 12,607 citations

APACHE II

1985 • 12,347 citations

A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study

1993 • 6,337 citations

A New Simplified Acute Physiology Score (SAPS II) Based on a European/North American Multicenter Study

1993 • 5,263 citations

Shock and Tissue Injury Induced by Recombinant Human Cachectin

1986 • 2,587 citations

Treatment of Gram-Negative Bacteremia and Septic Shock with HA-1A Human Monoclonal Antibody against Endotoxin

1991 • 1,611 citations

Pathogenetic Mechanisms of Septic Shock

1993 • 1,577 citations

The Pathogenesis of Sepsis

1991 • 1,376 citations

The complex pattern of cytokines in serum from patients with meningococcal septic shock. Association between interleukin 6, interleukin 1, and fatal outcome.

1989 • 1,183 citations

Septic Shock in Humans

1990 • 1,170 citations

Plasma Cytokine and Endotoxin Levels Correlate with Survival in Patients with the Sepsis Syndrome

1993 • 1,068 citations

Interleukin 1 induces a shock-like state in rabbits. Synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition.

1988 • 990 citations

Mortality Probability Models (MPM II) Based on an International Cohort of Intensive Care Unit Patients

1993 • 984 citations

Recombinant human interleukin 1 receptor antagonist in the treatment of patients with sepsis syndrome. Results from a randomized, double-blind, placebo-controlled trial. Phase III rhIL-1ra Sepsis Syndrome Study Group

1994 • 920 citations

Interleukin-1 receptor antagonist reduces mortality from endotoxin shock

1990 • 865 citations

Increased plasma levels of interleukin-6 in sepsis [see comments]

1989 • 813 citations

A Controlled Clinical Trial of E5 Murine Monoclonal IgM Antibody to Endotoxin in the Treatment of Gram-Negative Sepsis

1991 • 741 citations

Recombinant Human Interleukin 1 Receptor Antagonist in the Treatment of Patients With Sepsis Syndrome

1994 • 714 citations

Sepsis syndrome: a valid clinical entity. Methylprednisolone Severe Sepsis Study Group.

1989 • 709 citations

Prognostic Values of Tumor Necrosis Factor/Cachectin, Interleukin-l, Interferon- , and Interferon- in the Serum of Patients with Septic Shock

1990 • 555 citations

Sepsis syndrome

1989 • 523 citations

Initial evaluation of human recombinant interleukin-1 receptor antagonist in the treatment of sepsis syndrome: A randomized, open-label, placebocontrolled multicenter trial

1994 • 488 citations

Treatment of Septic Shock with Human Monoclonal Antibody HA-1A

1994 • 474 citations

Selected Treatment Strategies for Septic Shock Based on Proposed Mechanisms of Pathogenesis

1994 • 450 citations

Influence of an anti-tumor necrosis factor monoclonal antibody on cytokine levels in patients with sepsis

1993 • 427 citations

Anticytokine Strategies in the Treatment of the Systemic Inflammatory Response Syndrome

1993 • 397 citations

A second large controlled clinical study of E5, a monoclonal antibody to endotoxin

1995 • 348 citations

Interleukin-1 receptor blockade improves survival and hemodynamic performance in Escherichia coli septic shock, but fails to alter host responses to sublethal endotoxemia.

1992 • 338 citations

An overview of mortality risk prediction in sepsis

1995 • 251 citations

Anti-Endotoxin Monoclonal Antibodies

1992 • 235 citations

The Clinical Evaluation of New Drugs for Sepsis

1993 • 202 citations

Pretreatment with recombinant murine tumor necrosis factor alpha/cachectin and murine interleukin 1 alpha protects mice from lethal bacterial infection.

1989 • 196 citations

Role of Interleukin‐l in Infectious Diseases

1992 • 178 citations

The Mortality of Hospital-Acquired Bloodstream Infections: Need for a New Vital Statistic?

1988 • 152 citations

Pro- and anti-inflammatory roles of interleukin-1 in recurrence of bacterial cell wall-induced arthritis in rats

1991 • 151 citations

Regression Models and Non-Proportional Hazards in the Analysis of Breast Cancer Survival

1984 • 145 citations

Human neutrophil bactericidal/permeability-increasing protein reduces mortality rate from endotoxin challenge

1994 • 122 citations

Effectiveness of a Human Monoclonal Anti-Endotoxin Antibody (HA-1A) in Gram-Negative Sepsis: Relationship to Endotoxin and Cytokine Levels

1992 • 109 citations

Round table conference on clinical trials for the treatment of sepsis

1995 • 98 citations

The interleukin-1 receptor antagonist can either reduce or enhance the lethality of Klebsiella pneumoniae sepsis in newborn rats

1993 • 80 citations

Endotoxin, TNF-alpha, Interleukin-6 and Parameters of the Cellular Immune System in Patients with Intraabdominal Sepsis

1992 • 72 citations

Risk assessment in recent clinical trials in sepsis/SIRS: lessons learned and future directions

1995 • 2 citations