A novel, mitogen-activated nuclear kinase is related to a Drosophila developmental regulator.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Basic local alignment search tool

1990 • 87,358 citations

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

IκB: a Specific Inhibitor of the NF-κB Transcription Factor

1988 • 2,203 citations

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

1991 • 1,693 citations

Out of Order

1993 • 1,370 citations

The regulation of transcription by phosphorylation

1992 • 1,316 citations

Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-κB transcription factor

1988 • 1,200 citations

[42] Detection and quantification of phosphotyrosine in proteins

1983 • 1,184 citations

Nuclear localization and regulation of erk- and rsk-encoded protein kinases.

1992 • 1,107 citations

A thousand and one protein kinases

1987 • 1,066 citations

[3] Protein kinase phosphorylation site sequences and consensus specificity motifs: Tabulations

1991 • 1,036 citations

brahma: A regulator of Drosophila homeotic genes structurally related to the yeast transcriptional activator SNF2SWI2

1992 • 951 citations

Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias

1992 • 944 citations

The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene

1992 • 850 citations

GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinase

1990 • 677 citations

Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts

1993 • 668 citations

Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia.

1993 • 658 citations

Mechanism of action of an acidic transcriptional activator in vitro

1991 • 557 citations

Ser-His-Glu triad forms the catalytic site of the lipase from Geotrichum candidum

1991 • 534 citations

The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript.

1993 • 523 citations

The role of phosphorylation and the CDC28 protein kinase in cell cycle-regulated nuclear import of the S. cerevisiae transcription factor SW15

1991 • 501 citations

In utero rearrangements in the trithorax-related oncogene in infant leukaemias

1993 • 450 citations

Human general transcription factor IIH phosphorylates the C-terminal domain of RNA polymerase II

1992 • 407 citations

Signal transduction from the cell surface to the nucleus through the phosphorylation of transcription factors

1994 • 404 citations

FK506 and cyclosporin, molecular probes for studying intracellular signal transduction

1993 • 389 citations

Microtubule‐associated‐protein (MAP) kinase activated by nerve growth factor and epidermal growth factor in PC12 cells

1990 • 386 citations

The bromodomain: a conserved sequence found in human,Drosophilaand yeast proteins

1992 • 375 citations

A cyclin A-protein kinase complex possesses sequence-specific DNA binding activity: p33cdk2 is a component of the E2F-cyclin A complex

1992 • 361 citations

The rate of nuclear cytoplasmic protein transport is determined by the casein kinase II site flanking the nuclear localization sequence of the SV40 T-antigen.

1991 • 351 citations

Rapid and reversible translocation of the catalytic subunit of cAMP-dependent protein kinase type II from the Golgi complex to the nucleus.

1985 • 317 citations

A Xenopus ribosomal protein S6 kinase has two apparent kinase domains that are each similar to distinct protein kinases.

1988 • 282 citations

The BCR gene encodes a novel serine/threonine kinase activity within a single exon

1991 • 273 citations

Molecular determinants of protein half‐lives in eukaryotic cells

1987 • 268 citations

Type 3 protein kinase C localization to the nuclear envelope of phorbol ester-treated NIH 3T3 cells.

1989 • 221 citations

Interaction Between Human Cyclin A and Adenovirus E1A-Associated p107 Protein

1992 • 216 citations

Cell Cycle—Regulated Binding of c-Abl Tyrosine Kinase to DNA

1992 • 202 citations

CTD kinase associated with yeast RNA polymerase II initiation factor b

1991 • 199 citations

The trithorax gene, a trans-acting regulator of the bithorax complex in Drosophila, encodes a protein with zinc-binding domains.

1990 • 196 citations

Molecular structure of a major insulin/mitogen-activated 70-kDa S6 protein kinase.

1990 • 194 citations

Cloning of ALL-1, the locus involved in leukemias with the t(4;11)(q21;q23), t(9;11)(p22;q23), and t(11;19)(q23;p13) chromosome translocations.

1991 • 185 citations

PEST sequences are signals for rapid intracellular proteolysis.

1990 • 166 citations

Both p21ras and pp60v-src are required, but neither alone is sufficient, to activate the Raf-1 kinase.

1992 • 142 citations

Eukaryotic protein kinases

1991 • 140 citations

trithorax regulates multiple homeotic genes in the bithorax and Antennapedia complexes and exerts different tissue-specific, parasegment-specific and promoter-specific effects on each

1993 • 119 citations

Genetic and molecular analysis of fs(1)h, a maternal effect homeotic gene in Drosophila

1986 • 117 citations

Regulation of activity of calcium activated neutral protease

1988 • 116 citations

Regulating transcription factor activity by phosphorylation

1992 • 115 citations

Signal transduction and nuclear targeting: regulation of transcription factor activity by subcellular localisation

1993 • 114 citations

Thrombin stimulates the activities of multiple previously unidentified protein kinases in platelets

1989 • 112 citations

Nuclear translocation of viral Jun but not of cellular Jun is cell cycle dependent.

1992 • 105 citations

Insulin-sensitive phosphorylation of serine 1293/1294 on the human insulin receptor by a tightly associated serine kinase.

1990 • 93 citations

The Drosophila fsh locus, a maternal effect homeotic gene, encodes apparent membrane proteins

1989 • 88 citations

Steroid hormone receptor phosphorylation: is there a physiological role?

1994 • 88 citations

A homologue of the Drosophila female sterile homeotic (fsh) gene in the class II region of the human MHC

1992 • 87 citations

Two yeast genes that encode unusual protein kinases.

1987 • 83 citations

Structural and evolutionary relationships in lipase mechanism and activation

1992 • 64 citations

THE ROLE OF DOSAGE OF THE REGION 7D1–7D5-6 OF THE X CHROMOSOME IN THE PRODUCTION OF HOMEOTIC TRANSFORMATIONS IN DROSOPHILA MELANOGASTER

1980 • 41 citations

The rel family of proteins

1992 • 41 citations

Pest sequences in nuclear proteins

1993 • 40 citations

Cloning and molecular characterization of the trithorax locus of Drosophila melanogaster.

1989 • 38 citations

A maternal effect mutation leading to deficiencies of organs and homeotic transformations in the adults ofDrosophila

1981 • 34 citations

Transcription factor phosphorylation by the DNA-dependent protein kinase

1993 • 28 citations

Active baculovirus recombinant p70s6k and p85s6k produced as a function of the infectious response.

1993 • 26 citations

Bristling with teeth

1991 • 10 citations

Growth hormone induces the tyrosine phosphorylation and nuclear accumulation of components of the ISGF3 transcription factor complex

1994 • 10 citations