Lipid fusion in oligonucleotide and gene delivery with cationic lipids

Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure.

1987 • 4,937 citations

Lipid polymorphism and the functional roles of lipids in biological membranes

1979 • 1,817 citations

Cellular and Molecular Barriers to Gene Transfer by a Cationic Lipid

1995 • 1,406 citations

Antisense Oligonucleotides as Therapeutic Agents—Is the Bullet Really Magical?

1993 • 1,306 citations

Enhanced gene delivery and mechanism studies with a novel series of cationic lipid formulations.

1994 • 1,306 citations

Use of resonance energy transfer to monitor membrane fusion

1981 • 1,274 citations

Mechanism of DNA Release from Cationic Liposome/DNA Complexes Used in Cell Transfection^,

1996 • 1,103 citations

Transfer of Genes to Humans: Early Lessons and Obstacles to Success

1995 • 1,023 citations

Cationic liposome-mediated transfection

1989 • 974 citations

A novel cationic liposome reagent for efficient transfection of mammalian cells

1991 • 844 citations

The role of dioleoyl phosphatidylethanolamine in cationic liposome mediated gene transfer

1995 • 779 citations

Efficient gene transfer into mammalian primary endocrine cells with lipopolyamine-coated DNA.

1989 • 709 citations

Fluorescence method for measuring the kinetics of fusion between biological membranes

1984 • 670 citations

Mechanism of oligonucleotide release from cationic liposomes.

1996 • 617 citations

Cationic lipids enhance cellular uptake and activity of phosphorothioate antisense oligonucleotides.

1992 • 609 citations

Mechanism of oligonucleotide uptake by cells: involvement of specific receptors?

1989 • 510 citations

DNA transfection mediated by cationic liposomes containing lipopolylysine: characterization and mechanism of action

1994 • 496 citations

Mode of formation and structural features of DNA-cationic liposome complexes used for transfection

1993 • 493 citations

Potentiation of Cationic Liposome-Mediated Gene Delivery by Polycations

1996 • 455 citations

New structures in complex formation between DNA and cationic liposomes visualized by freeze—fracture electron microscopy

1994 • 425 citations

Interactions of mammalian cells with lipid dispersions containing novel metabolizable cationic amphiphiles

1990 • 424 citations

Phosphatodylethanolamine liposomes: drug delivery, gene transfer and immunodiagnostic applications

1992 • 365 citations

Intracellular distribution of microinjected antisense oligonucleotides.

1991 • 362 citations

Endocytosis and intracellular processing accompanying transfection mediated by cationic liposomes

1996 • 352 citations

Fusion of cationic liposomes with mammalian cells occurs after endocytosis

1995 • 337 citations

Delivery of plasmid DNA into mammalian cell lines using pH-sensitive liposomes: comparison with cationic liposomes.

1992 • 334 citations

Cardiolipin forms hexagonal structures with divalent cations

1972 • 325 citations

Calorimetric studies of the gel-fluid (L.beta.-L.alpha.) and lamellar-inverted hexagonal (L.alpha.-HII) phase transitions in dialkyl- and diacylphosphatidylethanolamines

1983 • 311 citations

Binding, uptake, and intracellular trafficking of phosphorothioate-modified oligodeoxynucleotides.

1995 • 308 citations

Interactions of cationic lipid vesicles with negatively charged phospholipid vesicles and biological membranes

1988 • 269 citations

Plasmid DNA entry into postmitotic nuclei of primary rat myotubes.

1995 • 266 citations

Liposomes in gene therapy

1996 • 258 citations

A serum-resistant cytofectin for cellular delivery of antisense oligodeoxynucleotides and plasmid DNA.

1996 • 255 citations

Targeted gene transfer into hepatoma cells with lipopolyamine-condensed DNA particles presenting galactose ligands: a stage toward artificial viruses.

1995 • 244 citations

pH‐sensitive liposomes mediate cytoplasmic delivery of encapsulated macromolecules

1985 • 239 citations

Proton-induced fusion of oleic acid-phosphatidylethanolamine liposomes

1985 • 204 citations

Formation of stable cationic lipid/DNA complexes for gene transfer.

1996 • 199 citations

Liposome-mediated delivery of deoxyribonucleic acid to cells: enhanced efficiency of delivery by changes in lipid composition and incubation conditions

1981 • 181 citations

A constant radius of curvature model for the organization of DNA in toroidal condensates.

1995 • 172 citations

Rapid nuclear accumulation of injected oligodeoxyribonucleotides.

1990 • 157 citations

Fusion activity of influenza virus. A comparison between biological and artificial target membrane vesicles.

1986 • 152 citations

Controllable gene therapy pharmaceutics of non-viral gene delivery systems

1996 • 147 citations

pH-sensitive, cationic liposomes: A new synthetic virus-like vector

1996 • 144 citations

Highly efficient DNA delivery mediated by pH-sensitive immunoliposomes

1989 • 140 citations

Fusion of liposomes containing a novel cationic lipid, N-[2,3-(dioleyloxy)propyl]-N,N,N-trimethylammonium: induction by multivalent anions and asymmetric fusion with acidic phospholipid vesicles

1989 • 135 citations

Liposomes as agents of DNA transfer

1993 • 133 citations

Small liposomes are better than large liposomes for specific drug delivery in vitro

1983 • 120 citations

Antigene, ribozyme and aptamer nucleic acid drugs: progress and prospects.

1995 • 119 citations

Cationic facial amphiphiles: a promising class of transfection agents.

1996 • 112 citations

Oligonucleotide-cationic liposome interactions. A physicochemical study

1994 • 98 citations

Cyclic amphipathic peptide-DNA complexes mediate high-efficiency transfection of adherent mammalian cells.

1993 • 95 citations

Liposomes as a carrier for intracellular delivery of antisense oligonucleotides: a real or magic bullet?

1996 • 88 citations

Oligonucleotides encapsulated in pH sensitive liposomes are efficient toward Friend retrovirus

1992 • 84 citations

Characterization of the fusogenic properties of Sendai virus: kinetics of fusion with erythrocyte membranes

1985 • 84 citations

Converting an alcohol to an amine in a cationic lipid dramatically alters the co-lipid requirement, cellular transfection activity and the ultrastructure of DNA-cytofectin complexes

1996 • 82 citations

Parameters influencing the introduction of plasmid DNA into cells by the use of synthetic amphiphiles as a carrier system

1995 • 81 citations

Cationic liposomes improve stability and intracellular delivery of antisense oligonucleotides into CaSki cells

1994 • 79 citations

Vesicle-forming synthetic amphiphiles

1995 • 76 citations

Acid- and calcium-induced structural changes in phosphatidylethanolamine membranes stabilized by cholesteryl hemisuccinate

1985 • 74 citations

Evaluation and Optimization of Different Cationic Liposome Formulations forin VivoGene Transfer

1996 • 74 citations

Effect of serum protein binding on real-time trafficking of liposomes with different charges analyzed by positron emission tomography

1996 • 57 citations

Physicochemical and morphological properties of complexes made of cationic liposomes and oligonucleotides

1998 • 46 citations

The counterion influence on cationic lipid-mediated transfection of plasmid DNA

1996 • 41 citations

Cationic liposome mediated transfection.

1989 • 34 citations

The effects of liposome surface charge and size on the intracellular delivery of clodronate and gallium in vitro

1994 • 29 citations

Looped oligonucleotides form stable hybrid complexes with a single-stranded DNA

1995 • 28 citations

Lipid and Protein Structure of Biological Membranes

2019 • 2 citations

Lipid Polymorphism

2019 • 2 citations