Binding, uptake, and intracellular trafficking of phosphorothioate-modified oligodeoxynucleotides.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Antisense Oligonucleotides as Therapeutic Agents—Is the Bullet Really Magical?

1993 • 1,306 citations

Antisense c-myb oligonucleotides inhibit intimal arterial smooth muscle cell accumulation in vivo

1992 • 749 citations

Characterization of oligonucleotide transport into living cells.

1989 • 739 citations

Current concepts in antisense drug design

1993 • 566 citations

Mechanism of oligonucleotide uptake by cells: involvement of specific receptors?

1989 • 510 citations

Inhibition of in vitro nuclear transport by a lectin that binds to nuclear pores.

1987 • 510 citations

Intimal hyperplasia after vascular injury is inhibited by antisense cdk 2 kinase oligonucleotides.

1994 • 290 citations

Heparin increases the affinity of basic fibroblast growth factor for its receptor but is not required for binding.

1994 • 262 citations

Ablation of transplanted HTLV-I tax-transformed tumors in mice by antisense inhibition of NF-kappa B

1993 • 249 citations

DNA binding to human leukocytes. Evidence for a receptor-mediated association, internalization, and degradation of DNA.

1985 • 240 citations

In vivo treatment of human leukemia in a scid mouse model with c-myb antisense oligodeoxynucleotides.

1992 • 223 citations

Exocytosis of pinocytosed fluid in cultured cells: kinetic evidence for rapid turnover and compartmentation.

1981 • 215 citations

Suppression of Philadelphia1 leukemia cell growth in mice by BCR-ABL antisense oligodeoxynucleotide.

1994 • 176 citations

Staphylococcal protein a bound to colloidal gold: A useful reagent to label antigen-antibody sites in electron microscopy

1977 • 174 citations

Dynamics of the internalization of phosphodiester oligodeoxynucleotides in HL60 cells

1993 • 172 citations

Rapid nuclear accumulation of injected oligodeoxyribonucleotides.

1990 • 157 citations

Cellular Uptake and Subcellular Distribution of Phosphorothioate Oligonucleotides into Cultured Cells

1992 • 137 citations

Analysis of Oligonucleotide Binding, Internalization, and Intracellular Trafficking Utilizing a Novel Radiolabeled Crosslinker

1992 • 95 citations

Cellular pharmacology of phosphorothioate homooligodeoxynucleotides in human cells.

1993 • 90 citations

Enhanced cellular uptake of biotinylated antisense oligonucleotide or peptide mediated by avidin, a cationic protein

1991 • 85 citations

Biologic and therapeutic significance of MYB expression in human melanoma.

1994 • 85 citations

Association of intercellular adhesion molecule 1 with the multichain high-affinity interleukin 2 receptor.

1990 • 68 citations

Mechanisms of inhibition of herpes simplex virus type 2 growth by 28-mer phosphorothioate oligodeoxycytidine

1990 • 67 citations

As Nature Intended? The Uptake of DNA and Oligonucleotides by Eukaryotic Cells

1993 • 65 citations

Antisense technology: biological utility and practical considerations

1993 • 62 citations

Characterization of the nuclear binding sites of oligodeoxyribonucleotides and their analogs.

1993 • 58 citations

Electron micrographic studies of transport of oligodeoxynucleotides across eukaryotic cell membranes.

1994 • 52 citations

Capillary gel electrophoresis and the analysis of DNA phosphorothioates

1993 • 35 citations

Preparation of 35S-labeled polyphosphorothioate oligodeoxyribonucleotides by use of hydrogen phosphonate chemistry

1990 • 33 citations

Biotin Uptake by Isolated Rat Liver Hepatocytes^a

1985 • 33 citations

Role of natural killer cells, in comparison with T lymphocytes and monocytes, in the regulation of normal human megakaryocytopoiesis in vitro.

1987 • 32 citations

Nucleocytoplasmic transport

1994 • 28 citations

Oligonucleotides in the treatment of leukemia

1994 • 23 citations

The characterization of the uptake of avidin-biotin complex by HeLa cells

1982 • 21 citations

Biotin transport into fully differentiated 3T3-L1 cells

1982 • 20 citations

Staphylococcal protein a bound to colloidal gold: A useful reagent to label antigen-antibody sites in electron microscopy

1977 • 2 citations