Selective induction of cell cycle regulatory genes cdk1 (p34^cdc2), cyclins a/b, and the tumor suppressor gene RB in transformed cells by okadaic acid

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Current protocols in molecular biology

1988 • 7,584 citations

SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene

1988 • 1,490 citations

Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

1988 • 1,440 citations

Human Retinoblastoma Susceptibility Gene: Cloning, Identification, and Sequence

1987 • 1,436 citations

Okadaic acid: a new probe for the study of cellular regulation

1990 • 1,396 citations

ANIMAL CELL CYCLES AND THEIR CONTROL

1992 • 1,239 citations

Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2

1987 • 1,153 citations

[17] A rapid alkaline extraction method for the isolation of plasmid DNA

1983 • 983 citations

The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element

1989 • 931 citations

Isolation of a human cyclin cDNA: Evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2

1989 • 920 citations

Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c-myc) in malignant neuroendocrine cells from a human colon carcinoma.

1983 • 764 citations

Human cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cyclin B

1990 • 730 citations

The fission yeast dis2+ gene required for chromosome disjoining encodes one of two putative type 1 protein phosphatases

1989 • 486 citations

An improved procedure for identifying and quantitating protein phosphatases in mammalian tissues

1989 • 482 citations

Rapid histone H3 phosphorylation in response to growth factors, phorbol esters, okadaic acid, and protein synthesis inhibitors

1991 • 468 citations

Driving the cell cycle: M phase kinase, its partners, and substrates

1990 • 404 citations

Cell cycle regulation of the human cdc2 gene.

1992 • 396 citations

Cell cycle control in eukaryotes: molecular mechanisms of cdc2 activation

1990 • 364 citations

Distinct, essential roles of type 1 and 2A protein phosphatases in the control of the fission yeast cell division cycle

1990 • 339 citations

Cell Cycle Regulation in the Yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe

1991 • 326 citations

The bimG gene of Aspergillus nidulans, required for completion of anaphase, encodes a homolog of mammalian phosphoprotein phosphatase 1

1989 • 326 citations

Okadaic acid, a potent inhibitor of type 1 and type 2A protein phosphatases, activates cdc2/H1 kinase and transiently induces a premature mitosis-like state in BHK21 cells.

1990 • 280 citations

Coordinate regulation of multiple histone mRNAs during the cell cycle in HeLa cells

1983 • 278 citations

Cdc2 H1 kinase is negatively regulated by a type 2A phosphatase in the Xenopus early embryonic cell cycle: evidence from the effects of okadaic acid.

1990 • 244 citations

INH, a negative regulator of MPF, is a form of protein phosphatase 2A

1991 • 231 citations

The retinoblastoma protein and the regulation of cell cycling

1992 • 198 citations

Involvement of a type 1 protein phosphatase encoded by bws1+ in fission yeast mitotic control

1989 • 188 citations

Involvement of protein phosphatases 1 and 2A in the control of M phase-promoting factor activity in starfish.

1989 • 141 citations

Periodic biosynthesis of the human M-phase promoting factor catalytic subunit p34 during the cell cycle.

1990 • 94 citations

Treatment of myeloid leukemic cells with the phosphatase inhibitor okadaic acid induces cell cycle arrest at either G1/S or G2/M depending on dose

1992 • 93 citations

Inhibition of mitosis by okadaic acid: possible involvement of a protein phosphatase 2A in the transition from metaphase to anaphase

1992 • 89 citations

The retinoblastoma protein and cell cycle regulation

1992 • 71 citations

Regulation of collagenase gene expression by okadaic acid, an inhibitor of protein phosphatases.

1990 • 66 citations

Transcriptional and post-transcriptional regulation of c-fos expression by the tumor promoter okadaic acid.

1991 • 65 citations

Hyperphosphorylation of retinoblastoma protein and p53 by okadaic acid, a tumor promoter.

1993 • 62 citations

Vimentin is hyperphosphorylated in primary human fibroblasts treated with okadaic acid

1991 • 61 citations

Inhibition of histone H1 kinase expression, retinoblastoma protein phosphorylation, and cell proliferation by the phosphatase inhibitor okadaic acid.

1993 • 61 citations

Transcriptional regulation in the eukaryotic cell cycle

1991 • 56 citations

Mitotic arrest and enhanced nuclear protein phosphorylation in human leukemia K562 cells by okadaic acid, a potent protein phosphatase inhibitor and tumor promoter

1991 • 55 citations

The tumor promoters 12-O-tetradecanoylphorbol-13-acetate and okadaic acid differ in toxicity, mitogenic activity and induction of gene expression

1989 • 42 citations

Okadaic acid--a valuable new tool for the study of signal transduction and cell cycle regulation?

1992 • 40 citations

Cytoskeleton involvement in the distribution of mRNP complexes and small cytoplasmic RNAs

1986 • 35 citations

Differential regulation of jun family gene expression by the tumor promoter okadaic acid.

1991 • 24 citations

Mitogenic activity in ovine uterine fluids: Characterization of a growth factor activity which specifically stimulates myoblast proliferations

1988 • 17 citations

Stability of histone mRNAs is related to their location in polysomes

1986 • 16 citations