Myc-induced proliferation and transformation require Akt-mediated phosphorylation of FoxO proteins

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

1999 • 6,443 citations

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

Mechanism of activation of protein kinase B by insulin and IGF-1.

1996 • 2,965 citations

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

1983 • 2,871 citations

Synthesis and Function of 3-Phosphorylated Inositol Lipids

2001 • 1,527 citations

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

2000 • 1,431 citations

Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability

2000 • 1,275 citations

Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle

1991 • 1,190 citations

Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras

1997 • 1,064 citations

Integration of Smad and Forkhead Pathways in the Control of Neuroepithelial and Glioblastoma Cell Proliferation

2004 • 1,008 citations

Genomic targets of the human c-Myc protein

2003 • 956 citations

Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy

2004 • 945 citations

DNA Repair Pathway Stimulated by the Forkhead Transcription Factor FOXO3a Through the Gadd45 Protein

2002 • 849 citations

Akt Phosphorylates the Yes-Associated Protein, YAP, to Induce Interaction with 14-3-3 and Attenuation of p73-Mediated Apoptosis

2003 • 805 citations

Coupling of a Signal Response Domain in IκBα to Multiple Pathways for NF-κB Activation

1995 • 706 citations

Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis

1996 • 700 citations

Cell Cycle Inhibition by FoxO Forkhead Transcription Factors Involves Downregulation of Cyclin D

2002 • 550 citations

Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation

2001 • 508 citations

N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation

2002 • 502 citations

Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27

1999 • 497 citations

The Essential Cofactor TRRAP Recruits the Histone Acetyltransferase hGCN5 to c-Myc

2000 • 479 citations

Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F

1997 • 468 citations

Phenotypes of c-Myc-deficient rat fibroblasts isolated by targeted homologous recombination.

1997 • 447 citations

A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR

2002 • 428 citations

Distinct requirements for Ras oncogenesis in human versus mouse cells

2002 • 425 citations

Genomic binding by theDrosophilaMyc, Max, Mad/Mnt transcription factor network

2003 • 392 citations

MYC recruits the TIP60 histone acetyltransferase complex to chromatin

2003 • 379 citations

Induction of ovarian cancer by defined multiple genetic changes in a mouse model system

2002 • 356 citations

Regulation of cyclin D2 gene expression by the Myc/Max/Mad network: Myc-dependent TRRAP recruitment and histone acetylation at the cyclin D2 promoter

2001 • 334 citations

Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase

2003 • 277 citations

Growth-factor-dependent mitogenesis requires two distinct phases of signalling

2001 • 258 citations

Myc Recruits P-TEFb to Mediate the Final Step in the Transcriptional Activation of the cad Promoter

2002 • 256 citations

Identification of a Myc-dependent step during the formation of active G1 cyclin-cdk complexes.

1995 • 243 citations

Analysis of Myc Bound Loci Identified by CpG Island Arrays Shows that Max Is Essential for Myc-Dependent Repression

2003 • 185 citations

c-Myc recruits P-TEFb for transcription, cellular proliferation and apoptosis

2003 • 179 citations

Mediator, Not Holoenzyme, Is Directly Recruited to the Heat Shock Promoter by HSF upon Heat Shock

2001 • 149 citations

TRRAP-Dependent and TRRAP-Independent Transcriptional Activation by Myc Family Oncoproteins

2002 • 137 citations

Reconstructing MYC: Figure 1.

2003 • 123 citations

Escape from premature senescence is not sufficient for oncogenic transformation by Ras

2001 • 101 citations

Direct trans-activation of the human cyclin D2 gene by the oncogene product Tax of human T-cell leukemia virus type I

2001 • 72 citations

Abolition of Cyclin-Dependent Kinase Inhibitor p16^Ink4a and p21^Cip1/Waf1 Functions Permits Ras-Induced Anchorage-Independent Growth in Telomerase-Immortalized Human Fibroblasts

2003 • 71 citations

BCR signals target p27Kip1 and cyclin D2 via the PI3-K signalling pathway to mediate cell cycle arrest and apoptosis of WEHI 231 B cells

2001 • 64 citations