Pharmacologic therapy of persistent pulmonary hypertension of the newborn

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

The Effect of High Doses of Calcium-Channel Blockers on Survival in Primary Pulmonary Hypertension

1992 • 1,541 citations

Nitric oxide activates guanylate cyclase and increases guanosine 3′:5′-cyclic monophosphate levels in various tissue preparations

1977 • 1,422 citations

Release of endothelin from the porcine aorta. Inhibition by endothelium-derived nitric oxide.

1990 • 1,066 citations

Inhaled Nitric Oxide in Full-Term and Nearly Full-Term Infants with Hypoxic Respiratory Failure

1997 • 837 citations

Inhaled Nitric Oxide and Persistent Pulmonary Hypertension of the Newborn

1997 • 787 citations

Low-Dose Nitric Oxide Therapy for Persistent Pulmonary Hypertension of the Newborn

2000 • 703 citations

Intracellular cyclic GMP receptor proteins

1993 • 655 citations

cGMP mediates the vascular and platelet actions of nitric oxide: confirmation using an inhibitor of the soluble guanylyl cyclase.

1996 • 473 citations

Endothelium-derived contracting factors.

1992 • 395 citations

Complete reversal of fatal pulmonary hypertension in rats by a serine elastase inhibitor

2000 • 373 citations

Inhaled Nitric Oxide for the Early Treatment of Persistent Pulmonary Hypertension of the Term Newborn: A Randomized, Double-Masked, Placebo-Controlled, Dose-Response, Multicenter Study

1998 • 355 citations

Sildenafil Ameliorates Effects of Inhaled Nitric Oxide Withdrawal

1999 • 344 citations

Surfactant Replacement Therapy for Meconium Aspiration Syndrome

1996 • 340 citations

Multicenter study of surfactant (beractant) use in the treatment of term infants with severe respiratory failure

1998 • 334 citations

Inhaled nitric oxide as a screening agent for safely identifying responders to oral calcium-channel blockers in primary pulmonary hypertension

1998 • 286 citations

Regulation of Cytosolic Guanylyl Cyclase by Nitric Oxide: The NO-Cyclic GMP Signal Transduction System

1994 • 232 citations

Pulmonary prostacyclin synthase overexpression in transgenic mice protects against development of hypoxic pulmonary hypertension

1999 • 226 citations

Elevated immunoreactive endothelin-1 levels in newborn infants with persistent pulmonary hypertension

1993 • 220 citations

Persistent fetal circulation: Newly recognized structural features

1976 • 195 citations

Tenascin-C, proliferation and subendothelial fibronectin in progressive pulmonary vascular disease.

1997 • 194 citations

The lungs in congenital bilateral renal agenesis and dysplasia.

1979 • 185 citations

Tenascin-C Is Induced With Progressive Pulmonary Vascular Disease in Rats and Is Functionally Related to Increased Smooth Muscle Cell Proliferation

1996 • 183 citations

Pathophysiology of congenital diaphragmatic hernia II: The fetal lamb CDH model is surfactant deficient

1992 • 183 citations

Inhibition of cyclic 3'-5'-guanosine monophosphate-specific phosphodiesterase selectively vasodilates the pulmonary circulation in chronically hypoxic rats.

1996 • 170 citations

Persistent hypoplasia of the lung after repair of congenital diaphragmatic hernia.

1976 • 163 citations

The Onset of Breathing at Birth Stimulates Pulmonary Vascular Prostacyclin Synthesis

1984 • 141 citations

Physiologic characterization of endothelin A and B receptor activity in the ovine fetal pulmonary circulation.

1994 • 138 citations

Dipyridamole attenuates rebound pulmonary hypertension after inhaled nitric oxide withdrawal in postoperative congenital heart disease

1998 • 135 citations

Chronic pulmonary hypertension increases fetal lung cGMP phosphodiesterase activity

1998 • 133 citations

Bronchoalveolar Lavage with KL4-Surfactant in Models of Meconium Aspiration Syndrome

1998 • 123 citations

Surfactant (beractant) therapy for infants with congenital diaphragmatic hernia on ECMO: Evidence of persistent surfactant deficiency

1994 • 122 citations

Continuous Nitric Oxide Inhalation Reduces Pulmonary Arterial Structural Changes, Right Ventricular Hypertrophy, and Growth Retardation in the Hypoxic Newborn Rat

1995 • 120 citations

Pathophysiology of congenital diaphragmatic hernia.

1996 • 119 citations

Inhaled nitric oxide in primary pulmonary hypertension

1998 • 117 citations

The cGMP phosphodiesterase inhibitor zaprinast enhances the effect of nitric oxide.

1995 • 116 citations

Refractory hypoxemia associated with neonatal pulmonary disease: The use and limitations of tolazoline

1979 • 105 citations

The Role of Nitric Oxide, Endothelin, and Prostaglandins in the Transition of the Pulmonary Circulation

1995 • 99 citations

Effects of Dipyridamole and Inhaled Nitric Oxide in Pediatric Patients with Pulmonary Hypertension

1998 • 97 citations

Surfactant Lavage in a Piglet Model of Meconium Aspiration Syndrome

1992 • 92 citations

Pulmonary Administration of Vasoactive Substances by Perfluorochemical Ventilation

1996 • 90 citations

Coordinated Regulation of Genes of the Nitric Oxide and Endothelin Pathways during the Development of Pulmonary Hypertension in Fetal Lambs

1998 • 89 citations

Mechanism of endothelin-1-induced pulmonary vasoconstriction.

1991 • 89 citations

Prostaglandin Inhibition Prevents the Fall in Pulmonary Vascular Resistance as a Result of Rhythmic Distension of the Lungs in Fetal Lambs

1991 • 88 citations

Tone-dependent responses to endothelin in the isolated perfused fetal sheep pulmonary circulation in situ

1991 • 88 citations

Pulmonary hemodynamics in fetal lambs during development at normal and increased oxygen tension

1992 • 84 citations

Effect of inhaled nitric oxide on endothelin-1 and cyclic guanosine 5`-monophosphate plasma concentrations in newborn infants with persistent pulmonary hypertension

1997 • 81 citations

Selective Pulmonary Vasodilation Induced by Aerosolized Zaprinast

1998 • 77 citations

Nitric oxide in the lung

1999 • 71 citations

Treatment of severe persistent pulmonary hypertension of the newborn with magnesium sulphate.

1992 • 70 citations

Nitric Oxide Inhalation Decreases Pulmonary Artery Remodeling in the Injured Lungs of Rat Pups

2000 • 70 citations

Low-dose Systemic Phosphodiesterase Inhibitors Amplify the Pulmonary Vasodilatory Response to Inhaled Prostacyclin in Experimental Pulmonary Hypertension

1999 • 66 citations

Pulmonary Vascular Remodeling in Neonatal Pulmonary Hypertension

1988 • 66 citations

Pulmonary vascular balance in congenital diaphragmatic hernia: Enhanced endothelin-1 gene expression as a possible cause of pulmonary vasoconstriction

1998 • 65 citations

Plasma Immunoreactive Endothelin-1 Concentrations in Infants with Persistent Pulmonary Hypertension of the Newborn

1996 • 63 citations

Endothelin-1 produces pulmonary vasodilation in the intact newborn lamb

1993 • 60 citations

Surfactant decreases pulmonary vascular resistance and increases pulmonary blood flow in the fetal lamb model of congenital diaphragmatic hernia

1996 • 59 citations

Immunoreactive endothelin concentrations in maternal and fetal blood

1990 • 57 citations

The hemodynamic effects of intrauterine hypoxia: An experimental model in newborn lambs

1976 • 57 citations

Surfactant Protein A Is Decreased in a Rat Model of Congenital Diaphragmatic Hernia

1998 • 56 citations

Pulmonary hemodynamics at birth: effect of acute cyclooxygenase inhibition in lambs

1988 • 54 citations

Acute Hemodynamic Effects of Nifedipine in Infants with Bronchopulmonary Dysplasia and Pulmonary Hypertension

1988 • 54 citations

Effects of prostacyclin on the fetal pulmonary circulation.

1981 • 53 citations

Prostaglandin D2 reverses induced pulmonary hypertension in the newborn lamb

1982 • 50 citations

Low-dose inhaled nitric oxide improves the oxygenation and ventilation of infants and children with acute, hypoxemic respiratory failure

1999 • 48 citations

Ventilation-induced release of prostaglandinlike material from fetal lungs

1980 • 48 citations

Disease-related response to inhaled nitric oxide in newborns with severe hypoxaemic respiratory failure

1998 • 47 citations

Dipyridamole Potentiates Pulmonary Vasodilation Induced by Acetylcholine and Nitric Oxide in the Ovine Fetus

1998 • 47 citations

Effect of prenatal glucocorticoids on pulmonary vascular muscularisation in nitrofen-induced congenital diaphragmatic hernia

1998 • 46 citations

Immunohistochemical distribution of surfactant apoprotein-A in congenital diaphragmatic hernia

1997 • 46 citations

Macrophage-derived Growth Factors in Wound Healing: Regulation of Growth Factor Production by the Oxygen Microenvironment

1989 • 46 citations

Persistent pulmonary hypertension of the newborn treated with magnesium sulfate in premature neonates.

1995 • 45 citations

Mechanisms by which endothelin 1 induces pulmonary vasoconstriction in the rabbit

1991 • 44 citations

Meconium aspiration induces a concentration-dependent pulmonary hypertensive response in newborn piglets

1998 • 44 citations

Pulmonary and Systemic Effects of the Phosphodiesterase Inhibitor Dipyridamole in Newborn Lambs with Persistent Pulmonary Hypertension

1998 • 42 citations

Methylprednisolone Attenuates the Pulmonary Hypertensive Response in Porcine Meconium Aspiration

1997 • 42 citations

Effects of adenosine in combination with calcium channel blockers in patients with primary pulmonary hypertension

1993 • 40 citations

Endotracheal instillation of prostacyclin in preterm infants with persistent pulmonary hypertension

1998 • 40 citations

The role of pulmonary inflammation in the development of pulmonary hypertension in newborn with meconium aspiration syndrome (MAS)

1999 • 38 citations

Pharmacokinetics and Pharmacodynamics of Nifedipine in Children with Bronchopulmonary Dysplasia and Pulmonary Hypertension

1991 • 38 citations

Prostacyclin Enhances Stretch-induced Surfactant Secretion in Alveolar Epithelial Type II Cells

1999 • 38 citations

E-4010, a selective phosphodiesterase 5 inhibitor, attenuates hypoxic pulmonary hypertension in rats

1999 • 38 citations

The cGMP-specific Phosphodiesterase Inhibitor E4021 Dilates the Pulmonary Circulation

1999 • 37 citations

Acute pulmonary vasodilatory properties of amlodipine in humans with pulmonary hypertension.

1996 • 36 citations

Contributions by Individual Lungs to the Surfactant Status in Congenital Diaphragmatic Hernia

1997 • 35 citations

Changes in lung eicosanoid content during normal and abnormal transition in perinatal lambs

1992 • 35 citations

Active collagen synthesis by pulmonary arteries in pulmonary hypertension complicated by congenital diaphragmatic hernia

1997 • 35 citations

The use of phosphodiesterase inhibitor (dipyridamole) to wean from inhaled nitric oxide

1996 • 35 citations

Improvement of mortality by long-term E4010 treatment in monocrotaline-induced pulmonary hypertensive rats.

1999 • 34 citations

Acute effects of oxygen, nifedipine, and diltiazem in patients with cystic fibrosis and mild pulmonary hypertension

1989 • 33 citations

Characterisation of the endothelin receptor mediating contraction of human pulmonary artery using BQ123 and Ro 46-2005

1994 • 33 citations

Effect of nitric oxide in meconium aspiration syndrome after treatment with surfactant

1997 • 33 citations

Management of Meconium-Stained Amniotic Fluid

1999 • 32 citations

Early therapeutic experience with the endothelin antagonist BQ-123 in pulmonary hypertension after congenital heart surgery

1999 • 31 citations

Pulmonary Parenchymal Abnormalities in Congenital Diaphragmatic Hernia

1996 • 30 citations

Estradiol improves pulmonary hemodynamics and vascular remodeling in perinatal pulmonary hypertension

2000 • 29 citations

Cerebral blood flow during treatment for pulmonary hypertension

1999 • 27 citations

Effect of Meconium Aspiration on Plasma Endothelin-1 Level and Pulmonary Hemodynamics in a Piglet Model

1999 • 27 citations

Effect of DMPPO, a phosphodiesterase type 5 inhibitor, on hypoxic pulmonary hypertension in rats

1998 • 24 citations

Endotracheal Administration of Tolazoline in Hypoxia-Induced Pulmonary Hypertension

1993 • 24 citations

Endothelin A Receptor Blockade Decreases Pulmonary Vascular Resistance in Premature Lambs with Hyaline Membrane Disease

1998 • 23 citations

Effects of prostaglandin D2 on pulmonary arterial pressure and oxygenation in newborn infants with persistent pulmonary hypertension

1988 • 23 citations

Dypiridamole, a cGMP phosphodiesterase inhibitor, transiently improves the response to inhaled nitric oxide in two newborns with congenital diaphragmatic hernia

1999 • 23 citations

A selective type V phosphodiesterase inhibitor, E4021, protects the development of right ventricular overload and medial thickening of pulmonary arteries in a rat model of pulmonary hypertension

1996 • 22 citations

Endotracheal tolazoline administration in neonates with persistent pulmonary hypertension.

1998 • 21 citations

Oxygen-Induced Pulmonary Vasodilation is Mediated by Adenosine Triphosphate in Newborn Lambs

1997 • 21 citations

Signal transduction in endothelin-induced contraction of rabbit pulmonary vein

1990 • 21 citations

Effects of Nebulized Nitroprusside on Pulmonary and Systemic Hemodynamics during Pulmonary Hypertension in Piglets

1998 • 20 citations

Inhaled nitric oxide improves oxygenation in piglets with meconium aspiration

1995 • 20 citations

Endotracheal tolazoline for severe persistent pulmonary hypertension of the newborn.

1995 • 17 citations

Reduction of hypoxic pulmonary vasoconstriction by magnesium chloride.

1968 • 17 citations

Strain differences in pulmonary hypertensive response to monocrotaline alkaloid and the beneficial effect of oral magnesium treatment.

1989 • 15 citations

Experimental and clinical effects of magnesium infusion in the treatment of neonatal pulmonary hypertension.

1995 • 15 citations

Diltiazem reduces pulmonary arterial pressures in recurrent pulmonary hypertension associated with pulmonary hypoplasia

1999 • 13 citations

Semotiadil improves survival of rats with monocrotaline-induced pulmonary hypertension: comparison with diltiazem

1996 • 11 citations

Adenosine triphosphate treatment for meconium aspiration‐induced pulmonary hypertension in pigs

1997 • 10 citations

Endothelin 1-21 Plasma Levels on the First and Fourth Postpartum Day in Normal Full-Term Neonates

1993 • 8 citations

Production of pulmonary vasodilation by tolazoline, independent of nitric oxide production in neonatal lambs

1996 • 8 citations

E4021, a Selective Phosphodiesterase 5 Inhibitor, Potentiates the Vasodilator Effect of Inhaled Nitric Oxide in Isolated Perfused Rat Lungs

1999 • 8 citations

Pulmonary oedema and pleural effusion in two patients with primary pulmonary hypertension treated with calcium channel blockers.

1996 • 6 citations

Bronchoalveolar Lavage with Dilute Surfaxin™ (KL4-Surfactant) for the Management of the Meconium Aspiration Syndrome (MAS)

1999 • 6 citations

Dual vasoactive effects of tolazoline on rabbit pulmonary arteries

1996 • 5 citations

Use of nitric oxide in meconium aspiration syndrome: lack of response

1998 • 4 citations

Effect of blood pressure cuffs on neonatal circulation: Their potential application to newborns with persistent pulmonary hypertension

1995 • 4 citations

Pharmacokinetics of Endobronchial Tolazoline Administration in Dogs

1999 • 2 citations

Deleted Work

1955 • 0 citations