Effects of Dipyridamole and Inhaled Nitric Oxide in Pediatric Patients with Pulmonary Hypertension

Nitric oxide activates guanylate cyclase and increases guanosine 3′:5′-cyclic monophosphate levels in various tissue preparations

1977 • 1,422 citations

Reduced Expression of Endothelial Nitric Oxide Synthase in the Lungs of Patients with Pulmonary Hypertension

1995 • 1,366 citations

Inhaled nitric oxide. A selective pulmonary vasodilator reversing hypoxic pulmonary vasoconstriction.

1991 • 1,134 citations

Inhaled nitric oxide as a cause of selective pulmonary vasodilatation in pulmonary hypertension

1991 • 1,062 citations

Biological actions and properties of endothelium-derived nitric oxide formed and released from artery and vein.

1989 • 977 citations

Inhaled nitric oxide in persistent pulmonary hypertension of the newborn

1992 • 865 citations

Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors

1990 • 860 citations

Low-dose inhalational nitric oxide in persistent pulmonary hypertension of the newborn

1992 • 731 citations

Nitric oxide regulates basal systemic and pulmonary vascular resistance in healthy humans.

1994 • 518 citations

Inhaled nitric oxide in congenital heart disease.

1993 • 400 citations

Dipyridamole

1987 • 397 citations

Use of inhaled nitric oxide and acetylcholine in the evaluation of pulmonary hypertension and endothelial function after cardiopulmonary bypass.

1993 • 371 citations

Negative feedback regulation of endothelial cell function by nitric oxide.

1993 • 371 citations

Inhaled Nitric Oxide for High-Altitude Pulmonary Edema

1996 • 324 citations

Selective inhibition of cyclic nucleotide phosphodiesterases of human, bovine and rat aorta

1986 • 301 citations

Impairment of endothelium-dependent pulmonary artery relaxation in children with congenital heart disease and abnormal pulmonary hemodynamics.

1993 • 249 citations

Cardiovascular effects of inhaled nitric oxide in patients with left ventricular dysfunction.

1994 • 248 citations

Characterization of a purified bovine lung cGMP-binding cGMP phosphodiesterase.

1990 • 232 citations

Hemodynamic effects of inhaled nitric oxide in heart failure

1994 • 204 citations

Inhaled nitric oxide reverses pulmonary vasoconstriction in the hypoxic and acidotic newborn lamb.

1993 • 204 citations

Pulmonary Vascular Response to Oxygen in Infants with Severe Bronchopulmonary Dysplasia

1985 • 199 citations

Pulmonary vascular response to oxygen in infants with severe bronchopulmonary dysplasia.

1985 • 197 citations

Inhaled nitric oxide leading to pulmonary edema in stable severe heart failure

1994 • 187 citations

Endothelium-dependent relaxation and cyclic GMP accumulation in rabbit pulmonary artery are selectively impaired by moderate hypoxia.

1989 • 172 citations

Inhibition of cyclic 3'-5'-guanosine monophosphate-specific phosphodiesterase selectively vasodilates the pulmonary circulation in chronically hypoxic rats.

1996 • 170 citations

ANOXIA AND HUMAN PULMONARY VASCULAR RESISTANCE 12

1951 • 163 citations

The Pulmonary Vascular Responses to Short-Term Hypoxia in Human Subjects

1952 • 151 citations

Biochemical Mechanisms Underlying Vascular Smooth Muscle Relaxation

1988 • 143 citations

Endothelium‐derived relaxing factor alters calcium fluxes in rabbit aorta: a cyclic guanosine monophosphate‐mediated effect.

1986 • 136 citations

Dipyridamole attenuates rebound pulmonary hypertension after inhaled nitric oxide withdrawal in postoperative congenital heart disease

1998 • 135 citations

The pattern of response of pulmonary and systemic arterial pressures in newborn and older infants to short periods of hypoxia

1957 • 133 citations

Evidence that cyclic guanosine monophosphate (cGMP) mediates endothelium-dependent relaxation

1985 • 131 citations

Hemodynamic effects of exogenous nitric oxide in ovine transitional pulmonary circulation

1992 • 130 citations

The cGMP phosphodiesterase inhibitor zaprinast enhances the effect of nitric oxide.

1995 • 116 citations

Endothelium-dependent relaxation and cyclic GMP accumulation in rabbit pulmonary artery are selectively impaired by moderate hypoxia.

1989 • 109 citations

Effects of Acute Hypoxia and Exercise on the Pulmonary Circulation

1960 • 103 citations

Prolonged pulmonary vasodilator action of inhaled nitric oxide by Zaprinast in awake lambs

1995 • 89 citations

M&B 22948, a cGMP phosphodiesterase inhibitor, is a pulmonary vasodilator in lambs

1993 • 88 citations

Dipyridamole, a cGMP phosphodiesterase inhibitor, causes pulmonary vasodilation in the ovine fetus

1995 • 88 citations

Chronic pulmonary hypertension in utero impairs endothelium-dependent vasodilation

1995 • 84 citations

Detection of coronary artery stenosis in children with Kawasaki disease. Usefulness of pharmacologic stress 201Tl myocardial tomography.

1989 • 84 citations

Role of endothelium in the maintenance of low pulmonary vascular tone in normal children.

1994 • 79 citations

Influence of Zaprinast on vascular tone and vasodilator responses in the cat pulmonary vascular bed

1993 • 76 citations

Increased lung vasoreactivity in children from Leadville, Colorado, after recovery from high-altitude pulmonary edema.

1985 • 64 citations

Effective control of refractory pulmonary hypertension after cardiac operations

1997 • 59 citations

Primary pulmonary hypertension in children living at high altitude

1963 • 56 citations

Dipyridamole potentiates the anti-aggregating and vasodilator activity of nitric oxide

1991 • 56 citations

Dipyridamole Potentiates Pulmonary Vasodilation Induced by Acetylcholine and Nitric Oxide in the Ovine Fetus

1998 • 47 citations

Increased lung vasoreactivity in children from Leadville, Colorado, after recovery from high-altitude pulmonary edema.

1985 • 42 citations

Enhancing effect of dipyridamole inhalation on adenosine‐induced bronchospasm in asthmatic patients

1988 • 35 citations

The use of phosphodiesterase inhibitor (dipyridamole) to wean from inhaled nitric oxide

1996 • 35 citations

Coronary Angiography of Kawasaki Disease with the Coronary Vasodilator Dipyridamole: Assessment of Distensibility of Affected Coronary Arterial Wall

1988 • 32 citations

Biochemical Mechanisms Underlying Vascular Smooth Muscle Relaxation

1988 • 19 citations

Dipyridamole-thallium-201 tomography documenting improved myocardial perfusion with therapy in Kawasaki disease

1988 • 17 citations

Inhibition of hypoxic pulmonary vasoconstriction by dipyridamole is not platelet mediated

1977 • 17 citations

Hypoxic pulmonary hypertension: Its modification by dipyridamole

1972 • 13 citations

Anti-platelet agents reduce morphological changes of chronic hypoxic pulmonary hypertension.

1987 • 7 citations

EFFECT OF THE PHOSPHODIESTERASE INHIBITOR DIPYRIDAMOLE ON INHALED NITRIC OXIDE (NO) IN NEWBORN LAMBS WITH PERSISTENT PULMONARY HYPERTENSION† 1972

1996 • 5 citations

DIPYRIDAMOLE CAUSES VASODILATION PRIMARILY VIA A2 ADENOSINE RECEPTOR INDEPENDENT MECHANISMS. † 210

1996 • 1 citations