NONANDROGENIC MEDIATORS OF PROSTATIC GROWTH

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

Insulin-Like Growth Factors and Their Binding Proteins: Biological Actions*

1995 • 4,419 citations

Studies on Prostatic Cancer. I. The Effect of Castration, of Estrogen and of Androgen Injection on Serum Phosphatases in Metastatic Carcinoma of the Prostate

1941 • 3,235 citations

The Transforming Growth Factor-beta Family

1990 • 3,028 citations

Mechanism of activation of the TGF-β receptor

1994 • 2,298 citations

Growth Factors and Cancer

1991 • 2,044 citations

Plasma Insulin-Like Growth Factor-I and Prostate Cancer Risk: A Prospective Study

1998 • 2,010 citations

Insulin-like growth factors and their binding proteins: biological actions

1995 • 1,976 citations

Human transforming growth factor-β complementary DNA sequence and expression in normal and transformed cells

1985 • 1,687 citations

Molecular and Cellular Aspects of the Insulin-Like Growth Factor I Receptor

1995 • 1,361 citations

Amplification of a Novel v- erb B-Related Gene in a Human Mammary Carcinoma

1985 • 1,064 citations

A mechanism for hormone-independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase

1999 • 983 citations

Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor, and epidermal growth factor.

1994 • 940 citations

Growth inhibition by TGF-β linked to suppression of retinoblastoma protein phosphorylation

1990 • 812 citations

Endothelial Cell Gene Expression of a Neutrophil Chemotactic Factor by TNF-α, LPS, and IL-1β

1989 • 785 citations

Identification of endothelin–1 in the pathophysiology of metastatic adenocarcinoma of the prostate

1995 • 627 citations

Hematopoietic growth factors.

1987 • 621 citations

Antiproliferative effects of 1,25-dihydroxyvitamin D3 on primary cultures of human prostatic cells.

1994 • 489 citations

Prostate-specific antigen (PSA) is an insulin-like growth factor binding protein-3 protease found in seminal plasma.

1992 • 478 citations

Interleukin-6 regulates prostate-specific protein expression in prostate carcinoma cells by activation of the androgen receptor.

1998 • 433 citations

Expression of Transforming Growth Factor-β in the Rat Ventral Prostate during Castration-Induced Programmed Cell Death

1989 • 417 citations

Exon switching and activation of stromal and embryonic fibroblast growth factor (FGF)-FGF receptor genes in prostate epithelial cells accompany stromal independence and malignancy.

1993 • 408 citations

The Heparan Sulfate–Fibroblast Growth Factor Family: Diversity of Structure and Function

1997 • 400 citations

Proliferating or interleukin 1-activated human vascular smooth muscle cells secrete copious interleukin 6.

1990 • 364 citations

Insulin-Like Growth Factors (IGFs), IGF Receptors, and IGF-Binding Proteins in Primary Cultures of Prostate Epithelial Cells*

1991 • 361 citations

Growth regulatory properties of endothelins

1993 • 342 citations

Endothelin-1 production and decreased endothelin B receptor expression in advanced prostate cancer.

1996 • 330 citations

Heparin-binding keratinocyte growth factor is a candidate stromal-to-epithelial-cell andromedin.

1992 • 287 citations

Circulating levels of interleukin-6 in patients with hormone refractory prostate cancer

1999 • 285 citations

Biological effects of prostate specific antigen as an insulin-like growth factor binding protein-3 protease

1994 • 273 citations

The int-2 gene product acts as an epithelial growth factor in transgenic mice.

1990 • 263 citations

Angiogenesis and Prostate Cancer: In vivo and In vitro Expression of Angiogenesis Factors by Prostate Cancer Cells

1998 • 251 citations

Eridothelin immunoreactivity of airway epithelium in asthmatic patients

1991 • 247 citations

Transforming growth factor-beta 1 overproduction in prostate cancer: effects on growth in vivo and in vitro.

1992 • 242 citations

Inhibition of growth of prostatic cancer cell lines by peptide analogues of insulin-like growth factor 1.

1993 • 240 citations

Antisense RNA to the type I insulin-like growth factor receptor suppresses tumor growth and prevents invasion by rat prostate cancer cells in vivo.

1996 • 239 citations

Bombesin stimulates growth of human prostatic cancer cellsin vitro

1990 • 227 citations

Characterization of the role of IL-6 in the progression of prostate cancer

1999 • 226 citations

The human prostatic carcinoma cell line LNCaP expresses biologically active, specific receptors for 1 alpha,25-dihydroxyvitamin D3.

1992 • 226 citations

Effect of Transforming Growth Factor-β¹on Proliferation and Death of Rat Prostatic Cells*

1990 • 218 citations

Changing pattern of expression of the epidermal growth factor receptor and transforming growth factor alpha in the progression of prostatic neoplasms.

1995 • 216 citations

Insulin‐like growth factor I: Action and receptor characterization in human prostate cancer cell lines

1993 • 215 citations

Elevated levels of insulin-like growth factor-binding protein-2 in the serum of prostate cancer patients.

1993 • 201 citations

Transforming Growth Factor-β2: cDNA Cloning and Sequence Analysis

1988 • 200 citations

Mammary cancer in transgenic mice expressing insulin-like growth factor II (IGF-II)

1995 • 190 citations

Prostate-specific antigen (PSA) is an insulin-like growth factor binding protein-3 protease found in seminal plasma

1992 • 189 citations

New bone formation in an osteoblastic tumor model is increased by endothelin-1 overexpression and decreased by endothelin A receptor blockade

1999 • 169 citations

Prostatic Epidermal Growth Factor Receptors and Their Regulation by Androgens*

1987 • 167 citations

Interleukin-8 serum levels in patients with benign prostatic hyperplasia and prostate cancer

1999 • 167 citations

Loss of expression of transforming growth factor beta type I and type II receptors correlates with tumor grade in human prostate cancer tissues.

1996 • 167 citations

Keratinocyte growth factor (KGF) can replace testosterone in the ductal branching morphogenesis of the rat ventral prostate.

1996 • 165 citations

Protein and messenger ribonucleic acid (mRNA) for the type 1 insulin-like growth factor (IGF) receptor is decreased and IGF-II mRNA is increased in human prostate carcinoma compared to benign prostate epithelium.

1996 • 162 citations

Expression of the c-erbB-2 (Her-2/neu) Oncoprotein in Human Prostatic Carcinoma

1993 • 159 citations

Neuroendocrine differentiation in prostatic carcinoma

1987 • 159 citations

Constitutive expression of insulin-like growth factor 1 and insulin-like growth factor 1 receptor abrogates all requirements for exogenous growth factors.

1992 • 159 citations

Guinea pig prostate is a rich source of nerve growth factor

1979 • 154 citations

The IGF Axis in the Prostate

1994 • 148 citations

Regulation of growth by a nerve growth factor-like protein which modulates paracrine interactions between a neoplastic epithelial cell line and stromal cells of the human prostate.

1991 • 141 citations

Prognostic significance of HER-2/neu gene amplification status by fluorescence in Situ hybridization of prostate carcinoma

1997 • 141 citations

Regulation of growth and epidermal growth factor receptor levels of LNCaP prostate tumor cells by different steroids

1988 • 139 citations

Effect of prolactin on the prostate

1994 • 131 citations

The effects of the endothelin family peptides on cultured osteoblastic cells from rat calvariae

1990 • 131 citations

Review of Peptide Growth Factors in Benign Prostatic Hyperplasia and Urological Malignancy

1995 • 129 citations

Complex regulation of TGFβ expression by retinoic acid in the vitamin A-deficient rat

1991 • 127 citations

Growth factors and their receptors as determinants in the proliferation and metastasis of human prostate cancer

1993 • 123 citations

Production of epidermal growth factor and transforming growth factor‐α by the androgen‐responsive LNCaP human prostate cancer cell line

1990 • 122 citations

Transforming Growth Factor

2008 • 121 citations

Heparin-binding keratinocyte growth factor is a candidate stromal-to- epithelial-cell andromedin

1992 • 121 citations

Endothelin-1 in the Human Prostate: Tissue Levels, Source of Production and Isometric Tension Studies

1993 • 120 citations

Peptide growth factors in the prostate as mediators of stromal epithelial interaction

1996 • 116 citations

Insulin-like growth factor-binding protein-2 and -3 expression in benign human prostate epithelium, prostate intraepithelial neoplasia, and adenocarcinoma of the prostate.

1996 • 115 citations

Endothelins in the control of cardiovascular and renal function

1993 • 113 citations

4 Transforming Growth Factor-β and Its Actions on Cellular Growth and Differentiation

1990 • 105 citations

Stromal cells of the human prostate: Initial isolation and characterization

1996 • 105 citations

Prostatic growth factor: purification and structural relationship to basic fibroblast growth factor

1987 • 105 citations

Comparative studies on testosterone and l-thyroxine effects on the synthesis of nerve growth factor in mouse submaxillary salivary glands

1980 • 103 citations

Insulin-like growth factor axis abnormalities in prostatic stromal cells from patients with benign prostatic hyperplasia.

1994 • 103 citations

Cultured human prostate‐derived fibroblasts produce a factor that stimulates their growth with properties indistinguishable from basic fibroblast growth factor

1989 • 101 citations

Expression of c‐erb B‐2/neu proto‐oncogene in human prostatic cancer tissues and cell lines

1992 • 101 citations

Elevated levels of insulin-like growth factor-binding protein-2 in the serum of prostate cancer patients

1993 • 100 citations

Prolactin stimulates transcription of growth-related genes in Nb2 T lymphoma cells

1990 • 97 citations

Distribution of Nerve Growth Factor-Like Protein and Nerve Growth Factor Receptor in Human Benign Prostatic Hyperplasia and Prostatic Adenocarcinoma

1992 • 97 citations

Expression of mRNA for epidermal growth factor, transforming growth factor-alpha and their receptor in human prostate tissue and cell lines

1993 • 94 citations

Epidermal Growth Factor Receptor mRNA Levels in Human Prostatic Tumors and Cell Lines

1990 • 94 citations

Infrequent RAS oncogene mutations in human prostate cancer

1992 • 93 citations

Molecular and cellular biology of prostate cancer.

1997 • 93 citations

Prolactin and Glucocorticoid Hormones Control Transcription of the β-Casein Gene by Kinetically Distinct Mechanisms

1990 • 92 citations

Growth hormone-releasing hormone antagonist MZ-5-156 inhibits growth of DU-145 human androgen-independent prostate carcinoma in nude mice and suppresses the levels and mRNA expression of insulin-like growth factor II in tumors

1998 • 91 citations

Transforming growth factor-beta 1 overproduction in prostate cancer: effects on growth in vivo and in vitro

1992 • 91 citations

Protein and messenger ribonucleic acid (mRNA) for the type 1 insulin- like growth factor (IGF) receptor is decreased and IGF-II mRNA is increased in human prostate carcinoma compared to benign prostate epithelium

1996 • 90 citations

The role of vitamin D in normal prostate growth and differentiation.

1996 • 90 citations

Dietary fenretinide, a synthetic retinoid, decreases the tumor incidence and the tumor mass of ras+myc-induced carcinomas in the mouse prostate reconstitution model system.

1993 • 88 citations

Localization of epidermal growth factor receptors in the human prostate by biochemical and immunocytochemical methods

1987 • 87 citations

Growth factor regulation of gene expression in the human prostatic carcinoma cell line LNCaP.

1993 • 85 citations

Mesenchymal-epithelial interactions and transforming growth factor-beta expression during mouse prostate morphogenesis.

1994 • 84 citations

Secretion of epidermal growth factor and related polypeptides by the DU 145 human prostate cancer cell line

1989 • 82 citations

Localization of Endothelin Receptors in the Human Prostate

1994 • 82 citations

Regulation of growth of LNCaP human prostate tumor cells by growth factors and steroid hormones

1991 • 81 citations

Divergent responses to epidermal growth factor in hormone sensitive and insensitive human prostate cancer cell lines

1992 • 81 citations

Heparin-binding growth factor/prostatropin attenuates inhibition of rat prostate tumor epithelial cell growth by transforming growth factor type beta

1988 • 80 citations

Interaction of epidermal growth factor and transforming growth factor beta in human prostatic epithelial cells in culture

1992 • 79 citations

Epidermal Growth Factor and Prostatic Carcinoma: An Immunohistochemical Study

1988 • 75 citations

Urogastrone–epidermal growth factor concentrations in prostatic fluid of normal individuals and patients with benign prostatic hypertrophy

1986 • 74 citations

Influence of transforming growth factor β1 and other growth factors on basic fibroblast growth factor level and proliferation of cultured human prostate‐derived fibroblasts

1993 • 74 citations

Expression and localization of transforming growth factor-beta receptors type I and type II in the rat ventral prostate during regression

1996 • 74 citations

Proliferation of cultured human prostate cancer cells is inhibited by insulin-like growth factor (IGF) binding protein-1: evidence for an IGF-II autocrine growth loop.

1995 • 71 citations

Growth responses of normal, benign hyperplastic, and malignant human prostatic epithelial cells in vitro to cholera toxin, pituitary extract, and hydrocortisone

1986 • 66 citations

Localization of epidermal growth factor receptor by immunohistochemical methods in human prostatic carcinoma, prostatic intraepithelial neoplasia, and benign hyperplasia.

1992 • 65 citations

Polypeptide modulators of prostatic growth and development.

1991 • 63 citations

Response of prostate cancer cells to peptide growth factors: transforming growth factor-beta.

1991 • 62 citations

Insulin-Like Growth Factor-I Receptors in Human Hyperplastic Prostate Tissue: Characterization, Tissue Localization, and Their Modulation by Chronic Treatment with a Gonadotropin-Releasing Hormone Analog*

1991 • 62 citations

The Role of Insulin‐Like Growth Factors in Prostate Biology

1996 • 60 citations

Massive amounts of immunoreactive endothelin in human seminal fluid.

1992 • 58 citations

Calcium signaling in prostate cancer cells: Evidence for multiple receptors and enhanced sensitivity to bombesin/GRP

1997 • 55 citations

Reexpression of the Type 1 Insulin-Like Growth Factor Receptor Inhibits the Malignant Phenotype of Simian Virus 40 T Antigen Immortalized Human Prostate Epithelial Cells¹

1997 • 55 citations

Androgenic regulation of epidermal growth factor in the mouse ventral prostate.

1988 • 54 citations

GRHきっ坑薬のMZ‐5‐156は,ヌードマウスのDU‐145ヒトアンドロゲン非依存性前立腺癌の成長を阻害し,腫よう内のIGF2のレベル及びmRNA発現を低下させる

1998 • 53 citations

Heparin‐binding growth factor isolated from human prostatic extracts

1988 • 53 citations

Interleukin 1β mediates the modulatory effects of monocytes on LNCaP human prostate cancer cells

1998 • 49 citations

Insulin‐Like Growth Factor Receptors

1991 • 48 citations

Modulation of neuroendocrine differentiation in prostate cancer by interleukin-1 and -2

1998 • 47 citations

Insulin-like growth factor axis abnormalities in prostatic stromal cells from patients with benign prostatic hyperplasia

1994 • 47 citations

Growth hormone and prostate cancer: guilty by association?

1999 • 47 citations

Insulin-like growth factor-binding protein-2 and -3 expression in benign human prostate epithelium, prostate intraepithelial neoplasia, and adenocarcinoma of the prostate

1996 • 45 citations

Peptide growth factors and prostate cancer: new models, new opportunities.

1998 • 45 citations

Growth factors and their cellular actions

1989 • 44 citations

Differential effects of vitamin D on normal human prostate epithelial and stromal cells in primary culture

1999 • 40 citations

Massive amounts of immunoreactive endothelin in human seminal fluid

1992 • 40 citations

Endothelin and menstruation

1996 • 40 citations

Insulin-like growth factor-I (IGF-I) and its binding protein IGFBP-4 in human prostatic hyperplastic tissue: gene expression and its cellular localization.

1994 • 40 citations

Role of Nerve Growth Factor‐like Protein in the Paracrine Regulation of Prostate Growth

1992 • 36 citations

Transforming growth factor-alpha and its receptor are expressed in the epithelium of the rat prostate gland.

1993 • 30 citations

Growth modulation of human prostatic cancer cells by interleukin-1 and interleukin-1 receptor antagonist

1995 • 28 citations

The inhibition of the paracrine progression of prostate cancer as an approach to early therapy of prostatic carcinoma

1992 • 26 citations

Mesenchymal-epithelial interactions and transforming growth factor-beta expression during mouse prostate morphogenesis

1994 • 24 citations

Proliferation of cultured human prostate cancer cells is inhibited by insulin-like growth factor (IGF) binding protein-1: evidence for an IGF- II autocrine growth loop

1995 • 23 citations

Keratinocyte growth factor as mediator of mesenchymal–epithelial interactions in the development of androgen target organs

1996 • 21 citations

Reexpression of the Type 1 Insulin-Like Growth Factor Receptor Inhibits the Malignant Phenotype of Simian Virus 40 T Antigen Immortalized Human Prostate Epithelial Cells

1997 • 21 citations

Literary Lunch

1999 • 17 citations

Insulin-like growth factor-I (IGF-I) and its binding protein IGFBP-4 in human prostatic hyperplastic tissue: gene expression and its cellular localization

1994 • 15 citations

The Role of the Endothelin Axis in Prostate Cancer

1999 • 13 citations

Transforming growth factor-alpha and its receptor are expressed in the epithelium of the rat prostate gland

1993 • 11 citations