4 Transforming Growth Factor-β and Its Actions on Cellular Growth and Differentiation

Novel Regulators of Bone Formation: Molecular Clones and Activities

1988 • 3,919 citations

Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix.

1986 • 2,499 citations

Human transforming growth factor-β complementary DNA sequence and expression in normal and transformed cells

1985 • 1,687 citations

Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth.

1986 • 1,617 citations

Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization.

1983 • 1,613 citations

Some recent advances in the chemistry and biology of transforming growth factor-beta.

1987 • 1,308 citations

Purification and characterization of an FSH releasing protein from porcine ovarian follicular fluid

1986 • 1,148 citations

Pituitary FSH is released by a heterodimer of the β-subunits from the two forms of inhibin

1986 • 1,071 citations

Proteolytic activation of latent transforming growth factor-beta from fibroblast-conditioned medium.

1988 • 962 citations

Accelerated Healing of Incisional Wounds in Rats Induced by Transforming Growth Factor-β

1987 • 938 citations

Deactivation of macrophages by transforming growth factor-β

1988 • 876 citations

Insulin-like growth factor II receptor as a multifunctional binding protein

1987 • 858 citations

Stimulation of the chemotactic migration of human fibroblasts by transforming growth factor beta.

1987 • 791 citations

Growth Inhibitor from BSC-1 Cells Closely Related to Platelet Type β Transforming Growth Factor

1984 • 779 citations

Transforming growth factor beta is an important immunomodulatory protein for human B lymphocytes.

1986 • 777 citations

Role of transforming growth factor-beta in the development of the mouse embryo.

1987 • 760 citations

A transcript from a Drosophila pattern gene predicts a protein homologous to the transforming growth factor-β family

1987 • 756 citations

Regulation of fibronectin and type I collagen mRNA levels by transforming growth factor-beta.

1987 • 736 citations

Complementary DNA sequences of ovarian follicular fluid inhibin show precursor structure and homology with transforming growth factor-β

1985 • 722 citations

Developmental Expression of PDGF, TGF-α, and TGF-β Genes in Preimplantation Mouse Embryos

1988 • 688 citations

Latent high molecular weight complex of transforming growth factor beta 1. Purification from human platelets and structural characterization.

1988 • 648 citations

Transforming growth factor beta is a bifunctional regulator of replication and collagen synthesis in osteoblast-enriched cell cultures from fetal rat bone.

1987 • 619 citations

Transforming growth factor beta 1 positively regulates its own expression in normal and transformed cells.

1988 • 604 citations

Effects of transforming growth factor beta on the functions of natural killer cells: depressed cytolytic activity and blunting of interferon responsiveness.

1986 • 579 citations

Transforming growth factor β (TGFβ) causes a persistent increase in steady-state amounts of type I and type III collagen and fibronectin mRNAs in normal human dermal fibroblasts

1987 • 579 citations

Phenotypic modulation of endothelial cells by transforming growth factor-beta depends upon the composition and organization of the extracellular matrix.

1988 • 571 citations

Osteoblasts synthesize and respond to transforming growth factor-type beta (TGF-beta) in vitro.

1987 • 561 citations

Reversible inhibition of normal human prokeratinocyte proliferation by type beta transforming growth factor-growth inhibitor in serum-free medium.

1986 • 559 citations

Distribution and modulation of the cellular receptor for transforming growth factor-beta.

1987 • 556 citations

Latent transforming growth factor-beta from human platelets. A high molecular weight complex containing precursor sequences.

1988 • 548 citations

Type beta transforming growth factor in human platelets: release during platelet degranulation and action on vascular smooth muscle cells.

1986 • 542 citations

Cartilage-inducing factor-A. Apparent identity to transforming growth factor-beta.

1986 • 533 citations

Inhibition of cytotoxic T cell development by transforming growth factor beta and reversal by recombinant tumor necrosis factor alpha.

1987 • 497 citations

The murine transforming growth factor-beta precursor.

1986 • 492 citations

Characterization of a membrane receptor for transforming growth factor-beta in normal rat kidney fibroblasts.

1984 • 477 citations

Inhibition of cytokine production by cyclosporin A and transforming growth factor beta.

1987 • 466 citations

Polypeptide Transforming Growth Factors Isolated from Bovine Sources and Used for Wound Healing in Vivo

1983 • 451 citations

Dual Endocrine Activity of the Testes

1932 • 451 citations

Enhanced production and extracellular deposition of the endothelial-type plasminogen activator inhibitor in cultured human lung fibroblasts by transforming growth factor-beta.

1986 • 443 citations

Inhibition of Endothelial Regeneration by Type-Beta Transforming Growth Factor from Platelets

1986 • 439 citations

Latent transforming growth factor-beta in serum. A specific complex with alpha 2-macroglobulin.

1987 • 434 citations

Transforming growth factor beta regulates the expression and structure of extracellular matrix chondroitin/dermatan sulfate proteoglycans.

1988 • 418 citations

Purification and characterization of Erythroid Differentiation Factor(EDF) isolated from human leukemia cell line THP-1

1987 • 409 citations

Reversible Inhibition of Mammary Gland Growth by Transforming Growth Factor-β

1987 • 408 citations

Regulation of myogenic differentiation by type beta transforming growth factor.

1986 • 408 citations

Two forms of transforming growth factor-β distinguished by multipotential haematopoietic progenitor cells

1987 • 407 citations

The effect of transforming growth factor-beta on cell proliferation and collagen formation by lung fibroblasts.

1987 • 399 citations

Transforming growth factor-beta is a potent immunosuppressive agent that inhibits IL-1-dependent lymphocyte proliferation.

1988 • 392 citations

The opposing effects of basic fibroblast growth factor and transforming growth factor beta on the regulation of plasminogen activator activity in capillary endothelial cells.

1987 • 378 citations

Conversion of a high molecular weight latent β-TGF from chicken embryo fibroblasts into a low molecular weight active β-TGF under acidic conditions

1985 • 366 citations

A Single Receptor Binds Both Insulin-Like Growth Factor II and Mannose-6-Phosphate

1988 • 363 citations

Embryonic expression pattern of TGF beta type-1 RNA suggests both paracrine and autocrine mechanisms of action

1988 • 347 citations

Cellular receptors for type beta transforming growth factor. Ligand binding and affinity labeling in human and rodent cell lines.

1985 • 344 citations

Transforming growth factor beta stimulates the expression of fibronectin and of both subunits of the human fibronectin receptor by cultured human lung fibroblasts.

1988 • 340 citations

Release from Density Dependent Growth Inhibition by Proteolytic Enzymes

1970 • 338 citations

The Theory of the Free-Martin

1916 • 337 citations

Normal embryo fibroblasts release transforming growth factors in a latent form

1984 • 336 citations

Cartilage-inducing factor-B is a unique protein structurally and functionally related to transforming growth factor-beta.

1987 • 336 citations

Absence of TGF-β Receptors and Growth Inhibitory Responses in Retinoblastoma Cells

1988 • 331 citations

Transforming growth factor-β inhibition of epithelial cell proliferation linked to the expression of a 53-kDa membrane receptor

1989 • 325 citations

Inhibitory effect of transforming growth factor-β on DNA synthesis of adult rat hepatocytes in primary culture

1985 • 325 citations

Inhibition of DNA synthesis in rat hepatocytes by platelet-derived type beta transforming growth factor.

1986 • 317 citations

Transforming growth factor-beta inhibits endothelial cell proliferation

1986 • 313 citations

Inhibition of endothelial cell proliferation by type β-transforming growth factor: Interactions with acidic and basic fibroblast growth factors

1986 • 312 citations

Structure of two human ovarian inhibins

1986 • 307 citations

Transforming growth factor-beta-induced growth inhibition and cellular hypertrophy in cultured vascular smooth muscle cells.

1988 • 305 citations

Transforming growth factor-beta 1 modulates the expression of class II histocompatibility antigens on human cells.

1988 • 298 citations

Activation of the bone-derived latent TGF beta complex by isolated osteoclasts

1989 • 281 citations

Transforming growth factor beta regulates the metabolism of proteoglycans in bovine cartilage organ cultures.

1988 • 274 citations

Transforming growth factor-β: Multiple effects on cell differentiation and extracellular matrices

1988 • 271 citations

Antibodies to the N-terminal portion of cartilage-inducing factor A and transforming growth factor beta. Immunohistochemical localization and association with differentiating cells.

1986 • 271 citations

Role for carbohydrate structures inTGF-β1 latency

1989 • 270 citations

Synergistic interaction of two classes of transforming growth factors from murine sarcoma cells.

1982 • 263 citations

Transforming growth factor-beta. A very potent inhibitor of myoblast differentiation, identical to the differentiation inhibitor secreted by Buffalo rat liver cells.

1986 • 247 citations

β-Transforming Growth Factor is stored in human blood platelets as a latent high molecular weight complex

1986 • 241 citations

The transforming growth factor-beta receptor type III is a membrane proteoglycan. Domain structure of the receptor.

1988 • 240 citations

Endothelial Adhesiveness for Blood Neutrophils Is Inhibited by Transforming Growth Factor-β

1988 • 224 citations

Proliferin secreted by cultured cells binds to mannose 6-phosphate receptors.

1988 • 221 citations

Identification of mannose 6-phosphate in two asparagine-linked sugar chains of recombinant transforming growth factor-beta 1 precursor.

1988 • 211 citations

Human transforming growth factor beta.alpha 2-macroglobulin complex is a latent form of transforming growth factor beta.

1988 • 209 citations

Isolation from murine sarcoma cells of novel transforming growth factors potentiated by EGF

1982 • 206 citations

Inhibin and beta type transforming growth factor (TGFβ) have opposite modulating effects on the follicle stimulating hormone (FSH)-induced aromatase activity of cultured rat granulosa cells

1986 • 206 citations

Transcriptional regulation of osteopontin production in rat osteosarcoma cells by type beta transforming growth factor.

1988 • 206 citations

Cellular distribution of type I and type II receptors for transforming growth factor-beta.

1986 • 203 citations

Transforming growth factor β stimulates collagen and glycosaminoglycan biosynthesis in cultured rabbit articular chondrocytes

1988 • 197 citations

Type β transforming growth factor (TGFβ) regulation of alkaline phosphatase expression and other phenotype‐related mRNAs in osteoblastic rat osteosarcoma cells

1987 • 196 citations

Differential proliferative effects of transforming growth factor-beta on human hematopoietic progenitor cells.

1988 • 195 citations

Thrombin active site regions required for fibroblast receptor binding and initiation of cell division.

1980 • 186 citations

The high molecular weight receptor to transforming growth factor-beta contains glycosaminoglycan chains.

1988 • 178 citations

Enhanced expression of TGF-β and c-fos mRNAs in the growth plates of developing human long bones

1988 • 173 citations

Type-β transforming growth factor inhibits proliferation and expression of alkaline phosphatase in murine osteoblast-like cells

1986 • 167 citations

Mouse embryonic transforming growth factors related to those isolated from tumor cells.

1982 • 151 citations

Beta transforming growth factors are potential regulators of B lymphopoiesis.

1987 • 145 citations

Hormonal regulation of inhibin production by cultured Sertoli cells

1987 • 139 citations

Subunit structure of a high-affinity receptor for type beta-transforming growth factor. Evidence for a disulfide-linked glycosylated receptor complex.

1985 • 139 citations

Heterodimeric transforming growth factor beta. Biological properties and interaction with three types of cell surface receptors.

1988 • 138 citations

Stimulation by insulin-like growth factors is required for cellular transformation by type beta transforming growth factor.

1985 • 137 citations

Platelet-derived growth factor. III. Identification of a platelet-derived growth factor receptor by affinity labeling.

1982 • 137 citations

Biphasic effects of type beta transforming growth factor on epidermal growth factor receptors in NRK fibroblasts. Functional consequences for epidermal growth factor-stimulated mitosis.

1985 • 132 citations

Agents that increase cAMP accumulation block endothelial c-sis induction by thrombin and transforming growth factor-beta.

1987 • 126 citations

Regulation of growth and differentiation of human keratinocytes by type beta transforming growth factor and epidermal growth factor.

1987 • 124 citations

Effects of transforming growth factor-beta on human lymphokine-activated killer cell precursors. Autocrine inhibition of cellular proliferation and differentiation to immune killer cells.

1988 • 117 citations

Transforming growth factor β alters plasminogen activator activity in human skin fibroblasts

1986 • 114 citations

Transforming growth factor-beta modulates the high-affinity receptors for epidermal growth factor and transforming growth factor-alpha.

1985 • 111 citations

Mouse embryos contain polypeptide growth factor(s) capable of inducing a reversible neoplastic phenotype in nontransformed cells in culture

1982 • 110 citations

Transforming growth factor β inhibits Leydig cell functions

1987 • 109 citations

Type beta transforming growth factor (TGF-β) is a potent stimulator of the basal secretion of follicle stimulating hormone (FSH) in a pituitary monolayer system

1986 • 107 citations

Structure and properties of the cellular receptor for transforming growth factor type beta

1986 • 104 citations

Transforming growth factor-β inhibits Leydig cell steroidogenesis in primary culture

1987 • 102 citations

Immunocytochemical localization of inhibin in rat and human reproductive tissues

1987 • 98 citations

Transforming growth factor type β (TGF β) inhibits G1 to S transition, but not activation of human B lymphocytes

1987 • 97 citations

Effect of transforming growth factor β on cell proliferation and glycosaminoglycan synthesis by rabbit growth-plate chondrocytes in culture

1988 • 96 citations

Transforming growth factor beta regulates the inhibitory actions of epidermal growth factor during granulosa cell differentiation.

1986 • 88 citations

Opposite and selective effects of epidermal growth factor and human platelet transforming growth factor-beta on the production of secreted proteins by murine 3T3 cells and human fibroblasts.

1986 • 84 citations

Cells regulate their mitogenic response to thrombin through release of protease nexin

1982 • 82 citations

Müllerian Duct Regression in the Embryo Correlated with Cytotoxic Activity Against Human Ovarian Cancer

1979 • 82 citations

The effects of platelet‐derived transforming growth factor β on normal human diploid gingival fibroblasts

1986 • 75 citations

Specific induction of secreted proteins by transforming growth factor-beta and 12-O-tetradecanoylphorbol-13-acetate. Relationship with an inhibitor of plasminogen activator.

1987 • 72 citations

Suppression of the EGF-dependent induction of c-myc proto-oncogene expression by transforming growth factor β in a human breast carcinoma cell line

1987 • 70 citations

Type beta transforming growth factor affects adrenocortical cell-differentiated functions.

1987 • 68 citations

Appearance of high affinity receptors for type beta transforming growth factor during differentiation of murine embryonal carcinoma cells.

1987 • 65 citations

Transforming growth factor-beta and retinoic acid modulate phenotypic transformation of normal rat kidney cells induced by epidermal growth factor and platelet-derived growth factor.

1986 • 64 citations

Plasminogen activator is a mitogen for astrocytes in developing cerebellum

1985 • 64 citations

Modulation of C-myc by transforming growth factor-β in human colon carcinoma cells

1988 • 64 citations

Mullerian Inhibiting Substance Inhibits Colony Growth of a Human Ovarian Carcinoma Cell Line

1982 • 64 citations

Stimulation of human vascular endothelial cell growth by a platelet-derived growth factor and thrombin

1979 • 62 citations

Mullerian Inhibiting Substance Inhibits Growth of a Human Ovarian Cancer in Nude Mice

1981 • 60 citations

Mullerian inhibiting substance reduction of colony growth of human gynecologic cancers in a stem cell assay

1985 • 53 citations

Coupling of TGF-β-induced mitogenesis to G-protein activation in AKR-2B cells

1988 • 52 citations

Bone-derived and recombinant transforming growth factor β′S are potent inhibitors of tumor cell growth

1987 • 50 citations

The Role of Extracellular Proteases in Cell Proliferation and Differentiation

1989 • 49 citations

Regulation of colony-stimulating factor 1-dependent macrophage precursor proliferation by type beta transforming growth factor.

1988 • 40 citations

Cell-mediated co-action of transforming growth factors: incubation of type beta with normal rat kidney cells produces a soluble activity that prolongs the ruffling response to type alpha.

1986 • 37 citations

Alteration in growth, cell morphology, and cytoskeletal structures of KB cells induced by epidermal growth factor and transforming growth factor-β

1988 • 37 citations

Direct inhibition of rat granulosa cell inhibin production by epidermal growth factor in vitro

1987 • 26 citations

One of two subunits of masking protein in latent TGF‐β is a part of pro‐TGF‐β

1989 • 25 citations

TGF β induces a sustained c-fos expression associated with stimulation or inhibition of cell growth in EL2 or NIH 3T3 fibroblasts

1988 • 25 citations

Characterization of a Drosophila protein that binds both epidermal growth factor and insulin-related growth factors.

1987 • 22 citations

Partial purification and characterization of masking protein for β-type transforming growth factor from rat platelets

1986 • 20 citations

Suppression of TNF-stimulated proliferation of diploid fibroblasts and TNF-induced cytotoxicity against transformed fibroblasts by TGF-β

1989 • 18 citations

Regulation of the production of a prolactin-like protein (MRP/PLF) in 3T3 cells and in the mouse placenta

1988 • 16 citations

Subrenal capsule assay to test the viability of parenterally delivered müllerian inhibiting substance

1984 • 15 citations

Progesterone and testosterone production by dispersed rat placental cells

1986 • 8 citations

Receptor G protein effector: The design of a biochemical switchboard

1988 • 4 citations

[Growth factors in early development].

1991 • 3 citations