Coexpression of Integrin αvβ3 and Matrix Metalloproteinase-2 (MMP-2) Coincides with MMP-2 Activation: Correlation with Melanoma Progression

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Matrix metalloproteinases and their inhibitors in connective tissue remodeling

1991 • 3,309 citations

Matrix Metalloproteinases: A Review

1993 • 2,998 citations

A matrix metalloproteinase expressed on the surface of invasive tumour cells

1994 • 2,561 citations

Mechanism Of Cell Surface Activation Of 72-kDa Type IV Collagenase

1995 • 1,576 citations

Localization of Matrix Metalloproteinase MMP-2 to the Surface of Invasive Cells by Interaction with Integrin αvβ3

1996 • 1,555 citations

Tumor Cell Interactions with the Extracellular Matrix During Invasion and Metastasis

1993 • 1,523 citations

Integrin distribution in malignant melanoma: association of the beta 3 subunit with tumor progression.

1990 • 771 citations

The TIMP2 Membrane Type 1 Metalloproteinase “Receptor” Regulates the Concentration and Efficient Activation of Progelatinase A

1998 • 578 citations

Transmembrane/cytoplasmic domain-mediated membrane type 1-matrix metalloprotease docking to invadopodia is required for cell invasion

1997 • 419 citations

Role of the alpha v beta 3 integrin in human melanoma cell invasion.

1992 • 414 citations

Transmembrane-deletion Mutants of the Membrane-type Matrix Metalloproteinase-1 Process Progelatinase A and Express Intrinsic Matrix-degrading Activity

1996 • 392 citations

Proteolysis and cell migration: creating a path?

1999 • 389 citations

Involvement of integrin alpha V gene expression in human melanoma tumorigenicity.

1992 • 380 citations

Tissue Inhibitor of Metalloproteinase-2 (TIMP-2) Binds to the Catalytic Domain of the Cell Surface Receptor, Membrane Type 1-Matrix Metalloproteinase 1 (MT1-MMP)

1998 • 285 citations

Differential expression of membrane-type matrix metalloproteinase and its correlation with gelatinase A activation in human malignant brain tumors in vivo and in vitro.

1996 • 278 citations

Expression of membrane-type matrix metalloproteinase in human gastric carcinomas

1995 • 267 citations

Activation of the precursor of gelatinase A/72 kda type IV collagenase/MMP‐2 in lung carcinomas correlates with the expression of membrane‐type matrix metalloproteinase (MT‐MMP) and with lymph node metastasis

1995 • 267 citations

Integrin alpha(v)beta3 promotes M21 melanoma growth in human skin by regulating tumor cell survival.

1999 • 238 citations

Proteolytic processing of membrane-type-1 matrix metalloproteinase is associated with gelatinase A activation at the cell surface

1998 • 223 citations

Adenoviral Gene Transfer of β3 Integrin Subunit Induces Conversion from Radial to Vertical Growth Phase in Primary Human Melanoma

1998 • 211 citations

Cell surface activation of progelatinase A (proMMP-2) and cell migration

1998 • 201 citations

Gelatinase A activity directly modulates melanoma cell adhesion and spreading.

1995 • 199 citations

Integrin expression in human melanoma cells with differing invasive and metastatic properties

1992 • 197 citations

Prognostic values of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 expression in bladder cancer

1998 • 190 citations

Requirement of the NPXY motif in the integrin beta 3 subunit cytoplasmic tail for melanoma cell migration in vitro and in vivo.

1995 • 186 citations

Matrix metalloproteinase-2 activation modulates glioma cell migration

1997 • 186 citations

Clinical significance of alpha(v)beta3 integrin and intercellular adhesion molecule-1 expression in cutaneous malignant melanoma lesions.

1997 • 174 citations

Human melanoma cells derived from lymphatic metastases use integrin alpha v beta 3 to adhere to lymph node vitronectin.

1992 • 170 citations

Enhanced production and activation of progelatinase A mediated by membrane-type 1 matrix metalloproteinase in human papillary thyroid carcinomas.

1999 • 160 citations

Expression and activation of matrix metalloproteinase‐2 (MMP‐2) and its co‐localization with membrane‐type 1 matrix metalloproteinase (MT1‐MMP) correlate with melanoma progression

2000 • 159 citations

Establishment and characterization of a human melanoma cell line (MV3) which is highly metastatic in nude mice

1991 • 158 citations

Matrix metalloproteinases in human melanoma cell lines and xenografts: increased expression of activated matrix metalloproteinase-2 (MMP-2) correlates with melanoma progression

1999 • 153 citations

Tissue Inhibitor of Matrix Metalloproteinase-2 Regulates Matrix Metalloproteinase-2 Activation by Modulation of Membrane-type 1 Matrix Metalloproteinase Activity in High and Low Invasive Melanoma Cell Lines

1999 • 151 citations

Expression and activation of matrix metalloproteinase-2 (MMP-2) and its co-localization with membrane-type 1 matrix metalloproteinase (MT1-MMP) correlate with melanoma progression

2000 • 150 citations

The 72 kDa type IV collagenase is modulated via differential expression of alpha v beta 3 and alpha 5 beta 1 integrins during human melanoma cell invasion.

1993 • 147 citations

MATRIX METALLOPROTEINASE-2 (72 kD TYPE IV COLLAGENASE) EXPRESSION OCCURS IN THE EARLY STAGE OF HUMAN MELANOCYTIC TUMOUR PROGRESSION AND MAY HAVE PROGNOSTIC VALUE

1996 • 146 citations

Prognostic value of MMP-2 immunoreactive protein (72 kD type IV collagenase) in primary skin melanoma

1998 • 136 citations

Expression of integrin αvβ3 correlates with activation of membrane-type matrix metalloproteinase-1 (MT1-MMP) and matrix metalloproteinase-2 (MMP-2) in human melanoma cellsin vitro andin vivo

2000 • 136 citations

Antigen expression of metastasizing and non-metastasizing human melanoma cells xenografted into nude mice

1991 • 124 citations

Role of the β3 Integrin Subunit in Human Primary Melanoma Progression

1998 • 70 citations

α_v‐Integrins in human melanoma: Gain of α_vβ₃ and loss OF α_vβ₅ are related to tumor progression in situ but not to metastatic capacity of cell lines in nude mice

1995 • 59 citations

Divergent patterns of matrix metalloproteinase activity during wound healing in ileum and colon of rats.

1996 • 57 citations

The role of the integrin vitronectin receptor, ?v?3 in melanoma metastasis

1995 • 51 citations

Regulation of matrix metalloproteinases following cellular transformation

1996 • 35 citations

Integrin β3 cDNA Transfection into a Highly Metastatic αvβ3-Negative Human Melanoma Cell Line Inhibits Invasion and Experimental Metastasis

1996 • 33 citations