Processing of a fusion protein by endoprotease in COS-1 cells for secretion of mature peptide by using a chimeric expression vector.

Intracellular Aspects of the Process of Protein Synthesis

1975 • 3,560 citations

pEF-BOS, a powerful mammalian expression vector

1990 • 1,641 citations

SRα Promoter: an Efficient and Versatile Mammalian cDNA Expression System Composed of the Simian Virus 40 Early Promoter and the R-U5 Segment of Human T-Cell Leukemia Virus Type 1 Long Terminal Repeat

1988 • 1,351 citations

Mammalian subtilisins: The long-sought dibasic processing endoproteases

1991 • 756 citations

The new enzymology of precursor processing endoproteases.

1992 • 608 citations

Arg-X-Lys/Arg-Arg motif as a signal for precursor cleavage catalyzed by furin within the constitutive secretory pathway

1991 • 590 citations

PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues.

1991 • 589 citations

Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2.

1990 • 579 citations

Cloning and Primary Sequence of a Mouse Candidate Prohormone Convertase PC1 Homologous to PC2, Furin, and Kex2: Distinct Chromosomal Localization and Messenger RNA Distribution in Brain and Pituitary Compared to PC2

1991 • 475 citations

Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans.

1991 • 449 citations

Intracellular Targeting and Structural Conservation of a Prohormone-Processing Endoprotease

1989 • 395 citations

Human fur gene encodes a yeast KEX2-like endoprotease that cleaves pro-beta-NGF in vivo.

1990 • 378 citations

Proinsulin processing by the subtilisin-related proprotein convertases furin, PC2, and PC3.

1992 • 300 citations

Expression of a human proprotein processing enzyme: correct cleavage of the von Willebrand factor precursor at a paired basic amino acid site.

1990 • 296 citations

Identification of a Second Human Subtilisin-Like Protease Gene in thefes/fpsRegion of Chromosome 15

1991 • 268 citations

Identification of the fourth member of the mammalian endoprotease family homologous to the yeast Kex2 protease. Its testis-specific expression.

1992 • 249 citations

Structure and expression of mouse furin, a yeast Kex2-related protease. Lack of processing of coexpressed prorenin in GH4C1 cells.

1990 • 219 citations

Structural homology between the human fur gene product and the subtilisin-like protease encoded by yeast KEX2

1990 • 202 citations

Functional expression of furin demonstrating its intracellular localization and endoprotease activity for processing of proalbumin and complement pro-C3.

1991 • 162 citations

The nucleotide sequence of a human immnnoglobulin C_γlgene

1982 • 158 citations

fur gene expression as a discriminating marker for small cell and nonsmall cell lung carcinomas.

1987 • 144 citations

Regulation of PACE propeptide-processing activity: requirement for a post-endoplasmic reticulum compartment and autoproteolytic activation.

1992 • 93 citations

Prohormone processing in Xenopus oocytes: characterization of cleavage signals and cleavage enzymes.

1991 • 52 citations

The structure of procalcitonin of the salmon as deduced from its cDNA sequence

1987 • 24 citations

A Neuroendocrine Peptide Derived from the Amino-Terminal Half of Rat Procalcitonin

1989 • 23 citations

Microinjected Xenopus Oocytes Secrete Mature, Biologically Active Parathyroid Hormone

1989 • 6 citations