Cytoprotection by Jun Kinase During Nitric Oxide–Induced Cardiac Myocyte Apoptosis

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

Requirement of JNK for Stress- Induced Activation of the Cytochrome c-Mediated Death Pathway

2000 • 1,703 citations

Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats.

1996 • 1,045 citations

Methods in nitric oxide research

1996 • 826 citations

Identification of a Dual Specificity Kinase That Activates the Jun Kinases and p38-Mpk2

1995 • 775 citations

Loss of a gp130 Cardiac Muscle Cell Survival Pathway Is a Critical Event in the Onset of Heart Failure during Biomechanical Stress

1999 • 666 citations

Stretch-induced programmed myocyte cell death.

1995 • 647 citations

Apoptosis and Heart Failure

2000 • 512 citations

Nitric oxide produced by human B lymphocytes inhibits apoptosis and Epstein-Barr virus reactivation

1994 • 509 citations

Inhibition of p38 Mitogen-Activated Protein Kinase Decreases Cardiomyocyte Apoptosis and Improves Cardiac Function After Myocardial Ischemia and Reperfusion

1999 • 504 citations

Caspase-3 Is the Primary Activator of Apoptotic DNA Fragmentation via DNA Fragmentation Factor-45/Inhibitor of Caspase-activated DNase Inactivation

1999 • 482 citations

Apoptosis of Vascular Smooth Muscle Cells Induced by In Vitro Stimulation With Interferon-γ, Tumor Necrosis Factor–α, and Interleukin-1β

1996 • 435 citations

The Bcr-Abl leukemia oncogene activates Jun kinase and requires Jun for transformation.

1995 • 399 citations

Early Activation of c-Jun N-terminal Kinase and p38 Kinase Regulate Cell Survival in Response to Tumor Necrosis Factor α

1998 • 382 citations

Myocyte apoptosis during acute myocardial infarction in the mouse localizes to hypoxic regions but occurs independently of p53.

1997 • 375 citations

Death by Design

1997 • 364 citations

Signal Transduction Pathways Regulated by Mitogen-activated/Extracellular Response Kinase Kinase Kinase Induce Cell Death

1996 • 346 citations

Cardiac Hypertrophy Induced by Mitogen-activated Protein Kinase Kinase 7, a Specific Activator for c-Jun NH2-terminal Kinase in Ventricular Muscle Cells

1998 • 335 citations

Molecular biology of nitric oxide synthases.

1998 • 326 citations

Nitric oxide–an endothelial cell survival factor

1999 • 281 citations

Modulation of Cytokine-Induced Cardiac Myocyte Apoptosis by Nitric Oxide, Bak, and Bcl-x

1999 • 276 citations

Nitric Oxide Suppresses Apoptosis via Interrupting Caspase Activation and Mitochondrial Dysfunction in Cultured Hepatocytes

1999 • 264 citations

Nitric Oxide Synthases and Cardiac Muscle

1997 • 259 citations

Isoform-Selective Activation of Protein Kinase C by Nitric Oxide in the Heart of Conscious Rabbits

1999 • 258 citations

Hypoxia-activated apoptosis of cardiac myocytes requires reoxygenation or a pH shift and is independent of p53

1999 • 247 citations

Atrial Natriuretic Peptide Induces Apoptosis in Neonatal Rat Cardiac Myocytes

1997 • 237 citations

Nitric Oxide Protects PC12 Cells from Serum Deprivation-Induced Apoptosis by cGMP-Dependent Inhibition of Caspase Signaling

1999 • 225 citations

The Activation of the c-Jun N-terminal Kinase and p38 Mitogen-activated Protein Kinase Signaling Pathways Protects HeLa Cells from Apoptosis Following Photodynamic Therapy with Hypericin

1999 • 217 citations

Activation of c-Jun N-Terminal Kinases and p38-Mitogen-activated Protein Kinases in Human Heart Failure Secondary to Ischaemic Heart Disease

1999 • 216 citations

Apoptosis in Myocardial Ischemia‐Reperfusion

1999 • 214 citations

Apoptosis of Cardiac Myocytes During Cardiac Allograft Rejection

1996 • 199 citations

Regulation of cardiac hypertrophy in vivo by the stress-activated protein kinases/c-Jun NH2-terminal kinases

1999 • 179 citations

Hypoxia/Reoxygenation Stimulates Jun Kinase Activity Through Redox Signaling in Cardiac Myocytes

1997 • 179 citations

Pulsatile Stretch Activates Mitogen-Activated Protein Kinase (MAPK) Family Members and Focal Adhesion Kinase (p125FAK) in Cultured Rat Cardiac Myocytes

1999 • 160 citations

The Mitogen-activated Protein Kinase Kinase MEK1 Stimulates a Pattern of Gene Expression Typical of the Hypertrophic Phenotype in Rat Ventricular Cardiomyocytes

1995 • 159 citations

Induction of Nitric Oxide Synthase in the Human Cardiac Allograft Is Associated With Contractile Dysfunction of the Left Ventricle

1996 • 155 citations

Interleukin-1β Regulation of Inducible Nitric Oxide Synthase and Cyclooxygenase-2 Involves the p42/44 and p38 MAPK Signaling Pathways in Cardiac Myocytes

1999 • 146 citations

Bruton’s tyrosine kinase regulates apoptosis and JNK/SAPK kinase activity

1997 • 137 citations

MEKK1 suppresses oxidative stress-induced apoptosis of embryonic stem cell-derived cardiac myocytes

1999 • 134 citations

MEK Kinase 1 (MEKK1) Transduces c-Jun NH2-terminal Kinase Activation in Response to Changes in the Microtubule Cytoskeleton

1999 • 125 citations

Adrenergic regulation of the skeletal alpha-actin gene promoter during myocardial cell hypertrophy.

1991 • 110 citations

Mass Spectrometric Analysis of Nitric Oxide-modified Caspase-3

1999 • 102 citations

Role of Mitogen-Activated Protein Kinases inS-Nitrosoglutathione-Induced Macrophage Apoptosis

1999 • 99 citations

Nitric oxide inhibits APO-1/Fas-mediated cell death.

1998 • 90 citations

Nitric oxide can function as either a killer molecule or an antiapoptotic effector in cardiomyocytes

1999 • 49 citations

Detection of Poly(ADP-Ribose) Polymerase and Its Apoptosis-Specific Fragment by a Nonisotopic Activity–Western Blot Technique

1995 • 47 citations

Nitric oxide donors attenuate myocardial stunning in conscious rabbits

1999 • 36 citations