Bcl-xL sequesters its C-terminal membrane anchor in soluble, cytosolic homodimers

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

The Bcl-2 Protein Family: Arbiters of Cell Survival

1998 • 5,359 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

2001 • 3,867 citations

The Bcl2 family: regulators of the cellular life-or-death switch

2002 • 3,782 citations

Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL

1996 • 2,627 citations

Isolation of intracellular membranes by means of sodium carbonate treatment: application to endoplasmic reticulum.

1982 • 1,765 citations

BCL-2, BCL-XL Sequester BH3 Domain-Only Molecules Preventing BAX- and BAK-Mediated Mitochondrial Apoptosis

2001 • 1,672 citations

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

2002 • 1,617 citations

Structure of Bcl-x _L -Bak Peptide Complex: Recognition Between Regulators of Apoptosis

1997 • 1,429 citations

Cytosol-to-membrane redistribution of Bax and Bcl-X_Lduring apoptosis

1997 • 1,117 citations

Structure of Bax

2000 • 1,066 citations

Multiple Bcl-2 family members demonstrate selective dimerizations with Bax.

1995 • 832 citations

Bax Is Present as a High Molecular Weight Oligomer/Complex in the Mitochondrial Membrane of Apoptotic Cells

2001 • 676 citations

Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation

2003 • 588 citations

Nonionic Detergents Induce Dimerization among Members of the Bcl-2 Family

1997 • 583 citations

Domain swapping: entangling alliances between proteins.

1994 • 528 citations

Bax in Murine Thymus Is a Soluble Monomeric Protein That Displays Differential Detergent-induced Conformations

1998 • 508 citations

Pathways of Apoptosis in Lymphocyte Development, Homeostasis, and Disease

2002 • 482 citations

Rationale for Bcl‐X_L/Bad peptide complex formation from structure, mutagenesis, and biophysical studies

2000 • 388 citations

The Structure of a Bcl-xL/Bim Fragment Complex

2003 • 349 citations

Characterization of the signal that directs Bcl-xL, but not Bcl-2, to the mitochondrial outer membrane

2003 • 343 citations

Mutagenesis of the BH3 Domain of BAX Identifies Residues Critical for Dimerization and Killing

1998 • 206 citations

Bcl-xL regulates apoptosis by heterodimerization-dependent and -independent mechanisms

1999 • 199 citations

The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity

2003 • 170 citations

BCL-2 Selectively Interacts with the BID-induced Open Conformer of BAK, Inhibiting BAK Auto-oligomerization

2003 • 144 citations

Pro-Apoptotic Apoptosis Protease–Activating Factor 1 (Apaf-1) Has a Cytoplasmic Localization Distinct from Bcl-2 or Bcl-XL

2000 • 142 citations

Solution Structure of Human BCL-w

2003 • 123 citations

Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies

2000 • 119 citations

Proapoptotic BH3-only proteins trigger membrane integration of prosurvival Bcl-w and neutralize its activity

2003 • 115 citations

Tissue expression and subcellular localization of the pro-survival molecule Bcl-w

2001 • 102 citations

Bcl-xS can form homodimers and heterodimers and its apoptotic activity requires localization of Bcl-xS to the mitochondria and its BH3 and loop domains

2001 • 42 citations

Biophysical Characterization of the Oligomeric State of Bax and Its Complex Formation with Bcl-XL

1999 • 34 citations

Evolution of oligomeric proteins

1999 • 23 citations

Generation and Characterization of Species-Specific Anti-Bcl-X_LMonoclonal Antibodies

2003 • 3 citations