Staurosporine up-regulates the expression of phorbol dibutyrate binding sites in human platelets

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

1980 • 8,534 citations

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

1988 • 4,243 citations

Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.

1990 • 3,250 citations

Staurosporine, a potent inhibitor of phospholipidCa++dependent protein kinase

1986 • 2,445 citations

Phorbol esters increase the amount of Ca2+, phospholipid-dependent protein kinase associated with plasma membrane

1983 • 1,304 citations

Protein kinase C as a possible receptor protein of tumor-promoting phorbol esters.

1983 • 890 citations

Optimal conditions for simultaneous purification of mononuclear and polymorphonuclear leucocytes from human blood by the hypaque-ficoll method

1980 • 554 citations

Phorbol myristate acetate mediates redistribution of protein kinase C in human neutrophils: potential role in the activation of the respiratory burst enzyme.

1985 • 300 citations

Comparison of protein kinase C functional assays to clarify mechanisms of inhibitor action

1988 • 190 citations

Factors influencing chelator-stable, detergent-extractable, phorbol diester-induced membrane association of protein kinase C. Differences between Ca2+-induced and phorbol ester-stabilized membrane bindings of protein kinase C.

1986 • 144 citations

Thapsigargin, a histamine secretagogue, is a non-12-O-tetradecanolphorbol-13-acetate (TPA) type tumor promoter in two-stage mouse skin carcinogenesis

1986 • 136 citations

Translocation of protein kinase C isozymes in thrombin-stimulated human platelets. Correlation with 1,2-diacylglycerol levels.

1992 • 130 citations

Protein kinase C heterogeneity in GH4C1 rat pituitary cells. Characterization of a Ca2(+)-independent phorbol ester receptor.

1990 • 126 citations

Differential regulation of protein kinase C isozymes by thyrotropin-releasing hormone in GH4C1 cells.

1991 • 124 citations

Contrasting actions of staurosporine, a protein kinase C inhibitor, on human neutrophils and primary mouse epidermal cells.

1988 • 121 citations

Receptor-mediated regulation of superoxide production in human neutrophils stimulated by phorbol myristate acetate.

1981 • 121 citations

Selective regulation of protein kinase C isoenzymes by oleic acid in human platelets.

1993 • 106 citations

Staurosporine inhibits the respiratory burst and induces exocytosis in human neutrophils

1989 • 98 citations

Enhancement of mononuclear procoagulant activity by platelet 12-hydroxyeicosatetraenoic acid.

1986 • 97 citations

Rapid Assay of Binding of Tumor-Promoting Phorbol Esters to Protein Kinase C1

1986 • 84 citations

Hormone- and phorbol ester-activated protein kinase C isozymes mediate a reorganization of the actin cytoskeleton associated with prolactin secretion in GH4C1 cells.

1992 • 82 citations

The protein kinase inhibitor staurosporine, like phorbol esters, induces the association of protein kinase C with membranes

1988 • 77 citations

Different translocation of three distinct PKC isoforms with tumor-promoting phorbol ester in human platelets

1991 • 76 citations

Ca2+ mobilization primes protein kinase C in human platelets. Ca2+ and phorbol esters stimulate platelet aggregation and secretion synergistically through protein kinase C.

1988 • 75 citations

Phorbol myristate acetate receptors in human polymorphonuclear neutrophils.

1985 • 75 citations

Relation of human neutrophil phorbol ester receptor occupancy and NADPH- oxidase activity

1982 • 69 citations

Signal transduction mechanisms of C1q-mediated superoxide production. Evidence for the involvement of temporally distinct staurosporine-insensitive and sensitive pathways.

1992 • 67 citations

Protein kinase inhibitor, staurosporine, induces a mature neuronal phenotype in SH‐SY5Y human neuroblastoma cells through an α‐, β‐, and ζ‐protein kinase C‐independent pathway

1993 • 58 citations

Translocation of protein kinase C in human polymorphonuclear neutrophils. Regulation by cytosolic Ca2(+)-independent and Ca2(+)-dependent mechanisms.

1990 • 51 citations

Inhibition of phorbol ester-caused induction of ornithine decarboxylase and tumor promotion in mouse skin by staurosporine, a potent inhibitor of protein kinase C

1988 • 48 citations

A protein kinase inhibitor, staurosporine, mimics nerve growth factor induction of neurotensin/neuromedin N gene expression.

1991 • 42 citations

Stimulation of the human neutrophil respiratory burst by formyl peptides is primed by a protein kinase inhibitor, staurosporine

1993 • 41 citations

The effect of putative protein kinase C inhibitors, K252a and staurosporine, on the human neutrophil respiratory burst activated by both receptor stimulation and post‐receptor mechanisms

1990 • 41 citations

Staurosporine, a protein kinase inhibitor, up-regulates the stimulation of human neutrophil respiratory burst by N-formyl peptides and platelet activating factor

1990 • 41 citations

Calcium rather than protein kinase C is the major factor to activate phospholipase D in FMLP-stimulated rabbit peritoneal neutrophils. Possible involvement of calmodulin/myosin L chain kinase pathway.

1992 • 40 citations

Staurosporine both activates and inhibits serine/threonine kinases in human platelets

1991 • 39 citations

Tumor-promoting activity of staurosporine, a protein kinase inhibitor on mouse skin.

1990 • 36 citations

Selective redistribution of protein kinase C isozymes by thapsigargin and staurosporine

1992 • 35 citations

Staurosporine stimulates phospholipase D activation in human polymorphonuclear leukocytes

1993 • 29 citations

Contrasting effects of the protein kinase C inhibitor staurosporine on the interleukin‐1 and phorbol ester activation pathways in the EL4–6.1 thymoma cell line

1992 • 23 citations

Nonphorbol tumor promoters okadaic acid and calyculin-A induce membrane translocation of protein kinase C

1992 • 23 citations

A protein kinase inhibitor, staurosporine, enhances the expression of phorbol dibutyrate binding sites in human polymorphonuclear leucocytes

1993 • 22 citations

Studies on the Regulatory Mechanisms of Interleukin-8 Gene Expression in Resting and IFN-y-Treated Neutrophils: Evidence on the Capability of Staurosporine of Inducing the Production of Interleukin-8 by Human Neutrophils

1993 • 16 citations

Phorbol 12,13-dibutyrate binding to intact human platelets. The role of cytosolic free Ca2+

1991 • 9 citations