Thrombus Formation on Atherosclerotic Plaques: Pathogenesis and Clinical Consequences

Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)

1994 • 8,631 citations

The Effect of Pravastatin on Coronary Events after Myocardial Infarction in Patients with Average Cholesterol Levels

1996 • 7,450 citations

Prevention of Coronary Heart Disease with Pravastatin in Men with Hypercholesterolemia

1995 • 7,378 citations

A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE)

1996 • 6,350 citations

Inflammation, Aspirin, and the Risk of Cardiovascular Disease in Apparently Healthy Men

1997 • 5,442 citations

Primary Prevention of Acute Coronary Events With Lovastatin in Men and Women With Average Cholesterol Levels

1998 • 5,293 citations

Prevention of Cardiovascular Events and Death with Pravastatin in Patients with Coronary Heart Disease and a Broad Range of Initial Cholesterol Levels

1998 • 5,229 citations

Lessons From Sudden Coronary Death

2000 • 3,869 citations

A Definition of Advanced Types of Atherosclerotic Lesions and a Histological Classification of Atherosclerosis

1995 • 3,361 citations

A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering Committee

1996 • 2,812 citations

Flow-mediated endothelial mechanotransduction

1995 • 2,728 citations

Use of a Monoclonal Antibody Directed against the Platelet Glycoprotein IIb/IIIa Receptor in High-Risk Coronary Angioplasty

1994 • 2,614 citations

Common Carotid Intima-Media Thickness and Risk of Stroke and Myocardial Infarction

1997 • 2,290 citations

Molecular Bases of the Acute Coronary Syndromes

1995 • 2,049 citations

A Randomized Comparison of Antiplatelet and Anticoagulant Therapy after the Placement of Coronary-Artery Stents

1996 • 2,032 citations

Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology.

1994 • 1,913 citations

Hemostatic Factors and the Risk of Myocardial Infarction or Sudden Death in Patients with Angina Pectoris

1995 • 1,807 citations

Protective Effects of Aspirin against Acute Myocardial Infarction and Death in Men with Unstable Angina

1983 • 1,740 citations

Low-Molecular-Weight Heparins

1997 • 1,529 citations

Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells.

1992 • 1,524 citations

Production of C-reactive protein and risk of coronary events in stable and unstable angina

1997 • 1,515 citations

Coronary Artery Calcium Area by Electron-Beam Computed Tomography and Coronary Atherosclerotic Plaque Area

1995 • 1,421 citations

The matrix‐degrading metalloproteinases

1992 • 1,383 citations

Randomised placebo-controlled and balloon-angioplasty-controlled trial to assess safety of coronary stenting with use of platelet glycoprotein-IIb/IIIa blockade

1998 • 1,367 citations

Coronary Plaque Erosion Without Rupture Into a Lipid Core

1996 • 1,247 citations

Edinburgh Artery Study: Prevalence of Asymptomatic and Symptomatic Peripheral Arterial Disease in the General Population

1991 • 1,187 citations

Aspirin, Sulfinpyrazone, or Both in Unstable Angina

1985 • 1,146 citations

Risk of thrombosis in human atherosclerotic plaques: role of extracellular lipid, macrophage, and smooth muscle cell content.

1993 • 1,132 citations

Macrophage infiltration in acute coronary syndromes. Implications for plaque rupture.

1994 • 1,125 citations

Randomised placebo-controlled and balloon-angioplasty-controlled trial to assess safety of coronary stenting with use of platelet glycoprotein-IIb/IIIa blockade

1998 • 1,097 citations

Laminar Shear Stress

1998 • 1,052 citations

Double-Blind Study of the Safety of Clopidogrel With and Without a Loading Dose in Combination With Aspirin Compared With Ticlopidine in Combination With Aspirin After Coronary Stenting

2000 • 1,035 citations

Atherosclerotic Disease of the Aortic Arch and the Risk of Ischemic Stroke

1994 • 983 citations

Blood-borne tissue factor: Another view of thrombosis

1999 • 982 citations

Fatty streak formation occurs in human fetal aortas and is greatly enhanced by maternal hypercholesterolemia. Intimal accumulation of low density lipoprotein and its oxidation precede monocyte recruitment into early atherosclerotic lesions.

1997 • 974 citations

Aspirin as an Antiplatelet Drug

1994 • 964 citations

Fibrinogen, viscosity, and white blood cell count are major risk factors for ischemic heart disease. The Caerphilly and Speedwell collaborative heart disease studies.

1991 • 953 citations

Tissue factor and hemostasis [published erratum appears in Blood 1988 Apr;71(4):1178]

1988 • 941 citations

Lewis A. Conner Memorial Lecture. Mechanisms leading to myocardial infarction: insights from studies of vascular biology.

1994 • 862 citations

Effects of Lipid Lowering by Pravastatin on Progression and Regression of Coronary Artery Disease in Symptomatic Men With Normal to Moderately Elevated Serum Cholesterol Levels

1995 • 846 citations

C-Reactive Protein as a Cardiovascular Risk Factor

1999 • 824 citations

Specific Synergy of Multiple Substrate–Receptor Interactions in Platelet Thrombus Formation under Flow

1998 • 809 citations

Ultrasound B-mode imaging in observational studies of atherosclerotic progression.

1993 • 785 citations

Evolution and progression of atherosclerotic lesions in coronary arteries of children and young adults.

1989 • 740 citations

The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor

1996 • 726 citations

A comparison of recombinant Hirudin with Heparin for the treatment of acute coronary syndromes. The Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) IIb Investigators

1996 • 719 citations

Effect of HMG-CoA Reductase Inhibitors on Coronary Artery Disease as Assessed by Electron-Beam Computed Tomography

1998 • 697 citations

Endothelial Dysfunction: Does It Matter? Is It Reversible?

1997 • 680 citations

A definition of the intima of human arteries and of its atherosclerosis-prone regions. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association.

1992 • 628 citations

Shed Membrane Microparticles With Procoagulant Potential in Human Atherosclerotic Plaques

1999 • 619 citations

Tissue Factor Modulates the Thrombogenicity of Human Atherosclerotic Plaques

1997 • 612 citations

Oral Anticoagulant Drugs

1991 • 579 citations

Gesammelte Abhandlungen zur wissenschaftlichen Medicin

1862 • 578 citations

Characterization of the relative thrombogenicity of atherosclerotic plaque components: Implications for consequences of plaque rupture

1994 • 575 citations

Tissue factor pathway inhibitor reduces mortality from Escherichia coli septic shock.

1993 • 552 citations

Hyperinsulinemia, Hyperglycemia, and Impaired Hemostasis

2000 • 537 citations

Platelet GPIIb-IIIa blockers

1999 • 526 citations

Smoking, Lipids, Glucose Intolerance, and Blood Pressure as Risk Factors for Peripheral Atherosclerosis Compared with Ischemic Heart Disease in the Edinburgh Artery Study

1992 • 507 citations

Randomized trial of intravenous heparin versus recombinant hirudin for acute coronary syndromes. The Global Use of Strategies to Open Occluded Coronary Arteries (GUSTO) IIa Investigators.

1994 • 505 citations

Role of NFkappaB in the mortality of sepsis.

1997 • 464 citations

Cholesterol Reduction Yields Clinical Benefit

1998 • 462 citations

Atheroembolism from the ascending aorta. An emerging problem in cardiac surgery.

1992 • 431 citations

Lethal E. coli septic shock is prevented by blocking tissue factor with monoclonal antibody.

1991 • 428 citations

Tick Anticoagulant Peptide (TAP) Is a Novel Inhibitor of Blood Coagulation Factor Xa

1990 • 414 citations

A macro and micro view of coronary vascular insult in ischemic heart disease.

1990 • 411 citations

Inhibition of endotoxin-induced activation of coagulation and fibrinolysis by pentoxifylline or by a monoclonal anti-tissue factor antibody in chimpanzees.

1994 • 405 citations

Value of Electron-Beam Computed Tomography for the Noninvasive Detection of High-Grade Coronary-Artery Stenoses and Occlusions

1998 • 393 citations

Transfer of tissue factor from leukocytes to platelets is mediated by CD15 and tissue factor

2000 • 387 citations

Combination antithrombotic therapy in unstable rest angina and non-Q-wave infarction in nonprior aspirin users. Primary end points analysis from the ATACS trial. Antithrombotic Therapy in Acute Coronary Syndromes Research Group.

1994 • 381 citations

Diabetes, fibrinogen, and risk of cardiovascular disease: The Framingham experience

1990 • 371 citations

Low-Molecular-Weight Heparin (Fragmin) During Instability in Coronary Artery Disease (FRISC)

1997 • 364 citations

Effectiveness of Clopidogrel and Aspirin Versus Ticlopidine and Aspirin in Preventing Stent Thrombosis After Coronary Stent Implantation

1999 • 350 citations

Long-term low-molecular-mass heparin in unstable coronary-artery disease: FRISC II prospective randomised multicentre study. FRagmin and Fast Revascularisation during InStability in Coronary artery disease. Investigators.

1999 • 341 citations

Fate of the patient with chronic leg ischaemia. A review article.

1989 • 303 citations

Mechanisms Determining Course and Outcome of Diabetic Patients Who Have Had Acute Myocardial Infarction

1997 • 301 citations

Lipoprotein(a). A unique risk factor for atherothrombotic disease.

1990 • 301 citations

Coagulation activation in diabetes mellitus: the role of hyperglycaemia and therapeutic prospects

1993 • 298 citations

Acute coronary syndromes: biology

1999 • 280 citations

Relation of Plaque Lipid Composition and Morphology to the Stability of Human Aortic Plaques

1997 • 276 citations

Platelet GPIIb/IIIa antagonists: the first anti-integrin receptor therapeutics.

1997 • 273 citations

Elevated Levels of Circulating Procoagulant Microparticles in Patients With Paroxysmal Nocturnal Hemoglobinuria and Aplastic Anemia

1999 • 267 citations

Lower extremity arterial disease and the aging process: A review

1992 • 254 citations

797-1 Differential Expression of Tissue Factor Protein in Directional Atherectomy Specimens from Patients with Stable and Unstable Coronary Syndromes

1995 • 254 citations

Frontiers in Interventional Cardiology

1998 • 250 citations

Atherosclerosis of the ascending aorta. Prevalence and role as an independent predictor of cerebrovascular events in cardiac patients.

1994 • 237 citations

Proximal aortic atheroma. An independent risk factor for cerebral ischemia.

1995 • 234 citations

Local Inhibition of Tissue Factor Reduces the Thrombogenicity of Disrupted Human Atherosclerotic Plaques

1999 • 233 citations

T ₂ -Weighted Contrast for NMR Characterization of Human Atherosclerosis

1995 • 219 citations

Mechanisms of arterial thrombosis in nonparallel streamlines: platelet thrombi grow on the apex of stenotic severely injured vessel wall. Experimental study in the pig model.

1989 • 217 citations

Biochemical and Pharmacological Properties of SANORG 34006, a Potent and Long-Acting Synthetic Pentasaccharide

1998 • 213 citations

Heightened Tissue Factor Associated With Tissue Factor Pathway Inhibitor and Prognosis in Patients With Unstable Angina

1999 • 198 citations

Task force 1. Pathogenesis of coronary disease: The biologic role of risk factors

1996 • 190 citations

Influence of Blockade at Specific Levels of the Coagulation Cascade on Restenosis in a Rabbit Atherosclerotic Femoral Artery Injury Model

1995 • 189 citations

Intermittent Claudication

1984 • 187 citations

Vulnerable Plaque: Pathobiology and Clinical Implications

1998 • 185 citations

Clopidogrel versus ticlopidine after intracoronary stent placement

1999 • 163 citations

Mechanical factors affecting hemostasis and thrombosis

1998 • 157 citations

Pathophysiology and clinical significance of atherosclerotic plaque rupture

1999 • 150 citations

Statins and cardiovascular diseases: the multiple effects of lipid-lowering therapy by statins

2000 • 142 citations

Significant correlations between tissue factor and thrombin markers in trauma and septic patients with disseminated intravascular coagulation.

1998 • 138 citations

Clopidogrel as adjunctive antiplatelet therapy during coronary stenting

1999 • 136 citations

Thrombus formation on ruptured atherosclerotic plaques and rethrombosis on evolving thrombi.

1992 • 132 citations

Haemostasis Factors in Angina Pectoris; Relation to Gender, Age and Acute-phase Reaction

1995 • 128 citations

Prevention of arterial reocclusion after thrombolysis with recombinant lipoprotein-associated coagulation inhibitor.

1991 • 123 citations

Disseminated intravascular coagulation: Clinical and laboratory aspects

1998 • 121 citations

Angiotensin-converting enzyme inhibition reduces monocyte chemoattractant protein-1 and tissue factor levels in patients with myocardial infarction

1999 • 119 citations

Tissue Factor: Then and Now

1995 • 119 citations

The contribution of thrombosis to the clinical expression of coronary atherosclerosis

1996 • 118 citations

Tissue Factor Pathway Inhibitor: Potential Therapeutic Applications

1997 • 117 citations

New antithrombotic agents

1999 • 116 citations

Long-Term Oral Anticoagulant Therapy in Patients With Unstable Angina or Suspected Non–Q-Wave Myocardial Infarction

1998 • 115 citations

Six-month angiographic and clinical follow-up of patients prospectively randomized to receive either tirofiban or placebo during angioplasty in the RESTORE trial

1998 • 109 citations

Activation of the tissue factor pathway of blood coagulation during prolonged hyperglycemia in young healthy men.

1999 • 107 citations

DX-9065a, an Orally Active, Specific Inhibitor of Factor Xa, Inhibits Thrombosis without Affecting Bleeding Time in Rats

1995 • 103 citations

Thromboresistance of Balloon-Injured Porcine Carotid Arteries After Local Gene Transfer of Human Tissue Factor Pathway Inhibitor

2000 • 95 citations

Inhibition of Tissue Factor–Mediated Coagulation Markedly Attenuates Stenosis After Balloon-Induced Arterial Injury in Minipigs

1997 • 95 citations

MECHANISM OF ACTION OF THROMBIN ON PLATELETS*

1962 • 94 citations

Antithrombotic Effects of Recombinant Human, Active Site–Blocked Factor VIIa in a Rabbit Model of Recurrent Arterial Thrombosis

1998 • 80 citations

Platelet-Leukocyte-Cross-Talk in Diabetes Mellitus

1997 • 77 citations

Monoclonal Antibody Against Tissue Factor Shortens Tissue Plasminogen Activator Lysis Time and Prevents Reocclusion in a Rabbit Model of Carotid Artery Thrombosis

1996 • 73 citations

Antithrombotic Strategies Targeting Thrombin Activities, Thrombin Receptors and Thrombin Generation

1997 • 73 citations

Adenovirus-Mediated Local Expression of Human Tissue Factor Pathway Inhibitor Eliminates Shear Stress–Induced Recurrent Thrombosis in the Injured Carotid Artery of the Rabbit

1999 • 73 citations

Dissociation of Antithrombotic Effect and Bleeding Time Prolongation in Rabbits by Inhibiting Tissue Factor Function

1997 • 72 citations

Specific factor Xa inhibition reduces restenosis after balloon angioplasty of atherosclerotic femoral arteries in rabbits.

1994 • 70 citations

Electron-Beam Computed Tomography, Coronary Artery Calcium, and Evaluation of Patients with Coronary Artery Disease

1998 • 68 citations

Purification and characterization of recombinant antistasin: A leech-derived inhibitor of coagulation factor Xa

1991 • 67 citations

USA Multicenter Study of the Pathobiology of Atherosclerosis in Youtha

1991 • 66 citations

Progression of the Culprit Lesion in Unstable Coronary Artery Disease With Warfarin and Aspirin Versus Aspirin Alone: Preliminary Study

1997 • 64 citations

Role of tissue factor in disseminated intravascular coagulation

1995 • 60 citations

Inhibition of Factor VIIa-Tissue Factor Coagulation Activity by a Hybrid Protein

1990 • 58 citations

Antithrombotic Effects of Orally Active Synthetic Antagonist of Activated Factor X in Nonhuman Primates

1995 • 57 citations

Mechanism on Disorders of Coagulation and Fibrinolysis in Diabetes

1996 • 56 citations

Effect of Selective Factor Xa Inhibition on Arterial Thrombus Formation Triggered by Tissue Factor/Factor VIIa or Collagen in an Ex Vivo Model of Shear-Dependent Human Thrombogenesis

1995 • 54 citations

Influence of coronary heart disease on morbidity and mortality after lower extremity revascularization surgery: A population-based study in Olmsted County, Minnesota (1970–1987)

1994 • 53 citations

Tolerability, pharmacokinetics, and pharmacodynamics of DX-9065a, a new synthetic potent anticoagulant and specific factor Xa inhibitor, in healthy male volunteers

1999 • 52 citations

Role of von Willebrand factor in mediating platelet-vessel wall interaction at low shear rate; the importance of perfusion conditions

1989 • 50 citations

Increased thrombus formation relates to ambient blood glucose and leukocyte count in diabetes mellitus type 2

2000 • 49 citations

Pathogenesis of Thrombosis in Coronary Artery Disease

1997 • 46 citations

Hypothesis

1998 • 45 citations

Comparison of Sustained Antithrombotic Effects of Inhibitors of Thrombin and Factor Xa in Experimental Thrombosis

1996 • 45 citations

Platelet Lipoprotein Interactions

1988 • 43 citations

Prevention of experimental arterial thrombosis by topical administration of active site–inactivated factor VIIa

1997 • 41 citations

Procoagulant activity after exposure of monocyte-derived macrophages to minimally oxidized low density lipoprotein. Co-localization of tissue factor antigen and nascent fibrin fibers at the cell surface.

1995 • 41 citations

Active Site–Blocked Factors VIIa and IXa Differentially Inhibit Fibrin Formation in a Human Ex Vivo Thrombosis Model

1995 • 40 citations

Platelet activation in diabetic cardiovascular autonomic neuropathy

1999 • 40 citations

Effects of Recombinant Human Tissue Factor Pathway Inhibitor on Thrombus Formation and ItsIn VivoDistribution in a Rat DIC Model

1996 • 35 citations

Reversibility of Platelet Thrombosis In Vivo

1996 • 33 citations

Structural Requirements for TFPI-Mediated Inhibition of Neointimal Thickening After Balloon Injury in the Rat

1999 • 32 citations

Effectiveness of aspirin and clopidogrel combination therapy in coronary stenting

1999 • 31 citations

Changes of plasma hemostatic markers during percutaneous transluminal coronary angioplasty in patients with chronic coronary artery disease

1999 • 28 citations

Activation Markers of Coagulation and Fibrinolysis: Alterations and Predictive Value in Acute Coronary Syndromes

1999 • 22 citations

Hemostasis and cardiovascular risk. The British and European experience.

1992 • 21 citations

Local Delivery of a Tissue Factor Antibody Reduces Early Leukocyte Infiltration but Fails to Limit Intimal Hyperplasia in Experimental Vein Grafts1

1998 • 14 citations

Microalbuminuria in IDDM is associated with increased expression of monocyte procoagulant activity

1998 • 12 citations

Dithiocarbamates Ameliorate the Effects of Endotoxin in a Rabbit Model of Disseminated Intravascular Coagulation

1999 • 11 citations

Platelet activation in diabetic microangiopathy

1998 • 11 citations

Discussion

1999 • 8 citations