Oral Anticoagulant Drugs

急性心筋梗塞の疑いのある17187症例におけるストレプトキナーゼ静脈内投与,アスピリン経口投与,上記2つの併用または無処置の無作偽試験 ISIS-2

1988 • 2,760 citations

PLACEBO-CONTROLLED, RANDOMISED TRIAL OF WARFARIN AND ASPIRIN FOR PREVENTION OF THROMBOEMBOLIC COMPLICATIONS IN CHRONIC ATRIAL FIBRILLATION

1989 • 1,845 citations

The Effect of Low-Dose Warfarin on the Risk of Stroke in Patients with Nonrheumatic Atrial Fibrillation

1990 • 1,503 citations

Maternal and fetal sequelae of anticoagulation during pregnancy

1980 • 984 citations

The mechanism of the effect of aspirin on human platelets. I. Acetylation of a particulate fraction protein.

1975 • 856 citations

Very Low Doses of Warfarin Can Prevent Thrombosis in Central Venous Catheters

1990 • 805 citations

Major bleeding in outpatients treated with warfarin: incidence and prediction by factors known at the start of outpatient therapy

1989 • 776 citations

Different Intensities of Oral Anticoagulant Therapy in the Treatment of Proximal-Vein Thrombosis

1982 • 753 citations

Vitamin K Dependent Modifications of Glutamic Acid Residues in Prothrombin

1974 • 750 citations

The Effect of Warfarin on Mortality and Reinfarction after Myocardial Infarction

1990 • 651 citations

PREVENTION OF VENOUS THROMBOSIS AND PULMONARY EMBOLISM IN INJURED PATIENTS

1959 • 650 citations

Warfarin Sodium versus Low-Dose Heparin in the Long-Term Treatment of Venous Thrombosis

1979 • 616 citations

NEED FOR LONG-TERM ANTICOAGULANT TREATMENT IN SYMPTOMATIC CALF-VEIN THROMBOSIS

1985 • 581 citations

The Mode of Action of Vitamin K

1974 • 527 citations

Adjusted Subcutaneous Heparin versus Warfarin Sodium in the Long-Term Treatment of Venous Thrombosis

1982 • 445 citations

The pathophysiology of the prethrombotic state in humans: insights gained from studies using markers of hemostatic system activation

1987 • 395 citations

Mechanism of coumarin action: significance of vitamin K epoxide reductase inhibition

1978 • 385 citations

Trial of Different Intensities of Anticoagulation in Patients with Prosthetic Heart Valves

1990 • 381 citations

Preliminary Report of the Stroke Prevention in Atrial Fibrillation Study

1990 • 348 citations

RANDOMISED COMPARISON OF TWO INTENSITIES OF ORAL ANTICOAGULANT THERAPY AFTER TISSUE HEART VALVE REPLACEMENT

1988 • 324 citations

Trial of combined warfarin plus dipyridamole or aspirin therapy in prosthetic heart valve replacement: Danger of aspirin compared with dipyridamole

1983 • 311 citations

Calibration of Reference Thromboplastins and Standardisation of the Prothrombin Time Ratio

1983 • 301 citations

Risks of Anticoagulant Therapy in Pregnant Women with Artificial Heart Valves

1986 • 294 citations

Warfarin STEREOCHEMICAL ASPECTS OF ITS METABOLISM AND THE INTERACTION WITH PHENYLBUTAZONE

1974 • 287 citations

Role of gamma-carboxyglutamic acid. An unusual protein transition required for the calcium-dependent binding of prothrombin to phospholipid.

1976 • 278 citations

Drug Interactions with Coumarin Anticoagulants

1971 • 277 citations

Pharmacokinetics and pharmacodynamics of the enantiomers of warfarin in man

1974 • 265 citations

Aspirin and the Stomach

1986 • 238 citations

Comparison of two levels of anticoagulant therapy in patients with substitute heart valves

1991 • 237 citations

Differentiation of metal ion-induced transitions of prothrombin fragment 1.

1977 • 235 citations

Molecular basis of vitamin K-dependent gamma-carboxylation

1990 • 231 citations

Molecular basis of vitamin K-dependent gamma-carboxylation

1990 • 224 citations

The Stereoselective Interaction of Warfarin and Metronidazole in Man

1976 • 216 citations

Studies on the optical enantiomorphs of warfarin in man

1974 • 215 citations

Bleeding in outpatients treated with warfarin: relation to the prothrombin time and important remediable lesions

1989 • 212 citations

The Hemostatic Defect Produced by Carbenicillin

1974 • 196 citations

Home Prothrombin Time Monitoring after the Initiation of Warfarin Therapy

1989 • 196 citations

Determinants of the response to oral anticoagulant drugs in man.

1970 • 193 citations

Assessment of Short-term Anticoagulant Administration after Cardiac Infarction

1969 • 179 citations

Drug Interactions with Coumarin Anticoagulants

1971 • 178 citations

Fixed minidose warfarin: a new approach to prophylaxis against venous thrombosis after major surgery.

1987 • 177 citations

Evidence that warfarin anticoagulant action involves two distinct reductase activities.

1982 • 168 citations

Flexible induction dose regimen for warfarin and prediction of maintenance dose.

1984 • 165 citations

Hemorrhagic Complications of Long-term Anticoagulant Therapy

1989 • 164 citations

Oral anticoagulants controlled by the British comparative thromboplastin versus low-dose heparin in prophylaxis of deep vein thrombosis

1978 • 161 citations

Warfarin versus dipyridamole-aspirin and pentoxifylline-aspirin for the prevention of prosthetic heart valve thromboembolism: a prospective randomized clinical trial.

1985 • 157 citations

Optimal Therapeutic Range for Oral Anticoagulants

1989 • 155 citations

Is warfarin sodium contraindicated in the lactating mother?

1983 • 151 citations

The warfarin-sulfinpyrazone interaction: stereochemical considerations

1986 • 150 citations

Vitamin K deficiency from dietary vitamin K restriction in humans

1988 • 147 citations

Hereditary Transmission of Exceptional Resistance to Coumarin Anticoagulant Drugs

1964 • 137 citations

A Controlled Comparison of Aspirin and Oral Anticoagulants in Prevention of Death after Myocardial Infarction

1982 • 134 citations

Clinical Pharmacokinetics of Oral Anticoagulants

1979 • 131 citations

The kinetics of activation of normal and gamma-carboxyglutamic acid-deficient prothrombins.

1985 • 131 citations

Evidence for Impaired Hepatic Vitamin K1 Metabolism in Patients Treated with N-Methyl-Thiotetrazole Cephalosporins

1984 • 130 citations

Stereoselective Interaction of Omeprazole with Warfarin in Healthy Men

1989 • 125 citations

Prothrombin requires two sequential metal-dependent conformational transitions to bind phospholipid. Conformation-specific antibodies directed against the phospholipid-binding site on prothrombin.

1986 • 124 citations

International Committee for Standardization in Haematology/International Committee on Thrombosis and Haemostasis: ICSH/ICTH recommendations for reporting prothrombin time in oral anticoagulant control.

1984 • 115 citations

Interaction of amiodarone with racemic warfarin and its separated enantiomorphs in humans

1987 • 114 citations

Dosage and control of oral anticoagulants: an international collaborative survey

1982 • 114 citations

Stereoselective Interaction of Trimethoprim-Sulfamethoxazole with the Separated Enantiomorphs of Racemic Warfarin in Man

1980 • 112 citations

Warfarin Therapy

1970 • 110 citations

Successful Progressive Anticoagulation in a Severe Protein C Deficiency and Previous Skin Necrosis at the Initiation of Oral Anticoagulant Treatment

1984 • 109 citations

The relationship between inhibition of vitamin K1 2,3‐epoxide reductase and reduction of clotting factor activity with warfarin.

1988 • 108 citations

A spectrum of partially carboxylated prothrombins in the plasmas of coumarin-treated patients

1977 • 104 citations

Elevated factor Xa activity in the blood of asymptomatic patients with congenital antithrombin deficiency.

1985 • 103 citations

Vitamin K and the Oral Anticoagulant Drugs

1976 • 102 citations

Local Haemorrhage and Necrosis of the Skin and Underlying Tissues, During Anti‐Coagulant Therapy with Dicumarol or Dicumacyl

1954 • 101 citations

Bleeding during acetylsalicylic acid and anticoagulant therapy in patients with reduced platelet reactivity after aortic valve replacement

1980 • 98 citations

Stereoselective interaction between the R enantiomer of warfarin and cimetidine.

1986 • 93 citations

A Novel Whole Blood Capillary Technic for Measuring the Prothrombin Time

1987 • 92 citations

Reliability and Clinical Impact of the Normalization of the Prothrombin Times in Oral Anticoagulant Control

1985 • 90 citations

Necrosis of skin induced by coumarin in a patient deficient in protein S.

1989 • 89 citations

Questions and Answers on Prothrombin Time Standardisation in Oral Anticoagulant Control

1985 • 88 citations

Oral anticoagulant drugs: pharmacokinetic aspects.

1978 • 85 citations

Successful Warfarin Anticoagulation Despite Protein C Deficiency and a History of Warfarin Necrosis

1986 • 84 citations

International Committee for Standardization in Haematology International Committee on Thrombosis and Haemostasis

1985 • 83 citations

Randomized prospective trial comparing the native prothrombin antigen with the prothrombin time for monitoring oral anticoagulant therapy

1990 • 78 citations

Immunoassays of human prothrombin species which correlate with functional coagulant activities.

1983 • 77 citations

Interaction of Chronic Daily Warfarin Therapy and Rifampin

1975 • 74 citations

INFLUENCE OF POSTOPERATIVE ANTICOAGULANT TREATMENT ON PATIENT SURVIVAL AFTER FEMOROPOPLITEAL VEIN BYPASS SURGERY

1988 • 74 citations

Antithrombotic Therapy for Cerebrovascular Disorders

1989 • 71 citations

The Biological Disappearance Rate of Prothrombin, Factors VII, IX and X from Plasma in Hypothyroidism, Hyperthyroidism, and During Fever

1963 • 71 citations

Decrease in protein C antigen and formation of an abnormal protein soon after starting oral anticoagulant therapy

1984 • 69 citations

Effects of Penicillin G on Platelet Aggregation, Release, and Adherence to Collagen

1973 • 68 citations

Prophylaxis of thromboembolism in pregnancy: an alternative

1985 • 64 citations

Effect of automation on prothrombin time test in NEQAS surveys.

1989 • 62 citations

Conformation-specific antibodies as probes of the gamma-carboxyglutamic acid-rich region of bovine prothrombin. Studies of metal-induced structural changes.

1979 • 61 citations

Effect of Sodium Dextrothyroxine in Patients Receiving Anticoagulants

1962 • 61 citations

Warfarin Therapy

1970 • 60 citations

Survival Time of Prothrombin and Factors VII, IX and X after Completely Synthesis Blocking Doses of Coumarin Derivatives

1963 • 58 citations

Warfarin Metabolism and Drug-Drug Interactions

1987 • 56 citations

Standardization of Laboratory Tests for Controlling Anticoagulant Therapy

1970 • 53 citations

INTERACTION OF IBUPROFEN AND WARFARIN ON PRIMARY HAEMOSTASIS

1989 • 53 citations

Warfarin Necrosis of the Skin and Subcutaneous Tissue of the Male External Genitalia

1983 • 52 citations

Anticoagulants in acute myocardial infarction. Results of a cooperative clinical trial

1973 • 49 citations

Use of Anticoagulants during Pregnancy

1989 • 48 citations

The warfarin‐cimetidine interaction: stereochemical considerations.

1986 • 47 citations

Two-step warfarin therapy. Prevention of postoperative venous thrombosis without excessive bleeding

1983 • 43 citations

ASPECTS OF ANTICOAGULANT ACTION: A Review of the Pharmacology, Metabolism and Toxicology of Warfarin and Congeners

1987 • 42 citations

Therapeutic ranges in anticoagulant administration.

1985 • 39 citations

A randomized trial of less intense postoperative warfarin or aspirin therapy in the prevention of venous thromboembolism after surgery for fractured hip

1989 • 38 citations

Clinically Significant Hemorrhage Due to Warfarin-Carbamazepine Interaction

1990 • 38 citations

Influence of Fever Upon the Action of 3,3′-Methylene-Bis-(4-Hydroxycoumarin) (Dicumarol)

1943 • 36 citations

Interaction of secobarbital with warfarin pseudoracemates

1980 • 35 citations

Long-term anticoagulant therapy after acute myocardial infarction

1985 • 32 citations

HEREDITARY RESISTANCE TO COUMARIN ANTICOAGULANT DRUGS IN MAN AND RAT*

1968 • 32 citations

Normal and warfarin-resistant rat hepatocyte metabolism of vitamin K 2,3-epoxide: Evidence for multiple pathways of hydroxyvitamin K formation

1988 • 27 citations

Oral anticoagulant in patients surviving myocardial infarction

1983 • 26 citations

HEREDITARY RESISTANCE TO COUMARIN ANTICOAGULANT DRUGS IN MAN AND RAT*

1968 • 25 citations

Monitoring effects of oral anticoagulants during treatment with heparin.

1984 • 22 citations

The Discriminatory Value of the P(A-a)O2 during Exercise in the Detection of Asbestosis in Asbestos Exposed Workers

1989 • 20 citations

Prolonged bleeding times and bleeding diathesis associated with moxalactam administration

1983 • 20 citations

Recent Developments in Antithrombotic Therapy

1969 • 19 citations

Discrimination of normal and abnormal prothrombin and protein C in plasma using a calcium ion-inhibited monoclonal antibody to a common epitope on several vitamin K-dependent proteins

1989 • 17 citations

Human sources and absorption of vitamin K in relation to anticoagulation stability

1965 • 17 citations

The Interpretation of Prothrombin Results: A National Survey

1969 • 15 citations

Dicoumarol-induced prothrombins containing 6, 7, and 8 γ-carboxyglutamic acid residues: isolation and characterization

1989 • 14 citations

Hereditary warfarin resistance. Investigation of a rare phenomenon

1985 • 12 citations

Lack of effect of fortified wine ingested during fasting and anticoagulant therapy

1981 • 7 citations